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Gene Review:

ABCF2 - ATP-binding cassette, sub-family F (GCN20)...

Homo sapiens

Synonyms: ABC28, ATP-binding cassette sub-family F member 2, EST133090, HUSSY-18, HUSSY18, ...

Nishimura, S. et al., Leo, J.C. et al., Ogawa, Y. et al., Tsuda, H. et al., Lin, V.C. et al., et al.

Lin, Woon, Aw, Guo,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ABCF2

CONCLUSIONS: These data suggest that ABCF2 protein may be a prognostic marker for ovarian clear cell ovarian adenocarcinoma [1].
Clinical role of ABCF2 expression in breast cancer [2].
ABCF2 had a negative relationship to distant metastasis [2].
In addition, ABCF2 expression was evaluated in clear cell adenocarcinomas derived from different organs [3].
The results showed that cytoplasmic ABCF2 expression was significantly higher in clear cell-type ovarian cancer specimens compared with other types (P < .0001) [3].

Psychiatry related information on ABCF2

The MABC Test examines children's motor skills in the areas of manual dexterity, ball skills and balance [4].

High impact information on ABCF2

Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses [1].
Second, PR blocker ZK98299 abolishes their effect on cell spreading and focal adhesion in ABC28 cells [5].
The cross-talk is corticosteroid specific because estradiol and thyroid hormone triiodothyronine have no effect on PR-transfected cells ABC28 [5].
At physiological concentrations, dexamethasone, cortisol, and aldosterone mimic the effects of progesterone by inducing significant growth inhibition, cell spreading, and focal adhesions in PR-positive ABC28 cells [5].
The present study addressed molecular mechanisms that mediate these anticancer effects of progesterone in the PR-transfected breast cancer cells ABC28 [6].

Biological context of ABCF2

CONCLUSION: ABCF2 was initially thought to be related to drug resistance [2].
Multivariate logistic regression model also demonstrated that cytoplasmic ABCF2 expression was associated with clear cell histology (odds ratio, 5.557; 95% confidence interval, 2.694-11.462; P < .0001) [3].

Anatomical context of ABCF2

ABCF2-positive tumors had longer disease-free survival (DFS) than -negative tumors in patients with lymph node metastasis (p = 0.001) [2].
The level of MT-1E mRNA expression in progesterone-treated and -untreated ABC28 cells remained similar as the parental cell line MDA-MB-231-C2 cells [7].

Analytical, diagnostic and therapeutic context of ABCF2

ABCF2 expression was examined by immunohistochemistry [2].

References

Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses. Tsuda, H., Ito, Y.M., Ohashi, Y., Wong, K.K., Hashiguchi, Y., Welch, W.R., Berkowitz, R.S., Birrer, M.J., Mok, S.C. Clin. Cancer Res. (2005) [Pubmed]
Clinical role of ABCF2 expression in breast cancer. Ogawa, Y., Tsuda, H., Hai, E., Tsuji, N., Yamagata, S., Tokunaga, S., Nakazawa, K., Tamamori, Y., Ogawa, M., Shimizu, S., Inoue, T., Nishiguchi, Y. Anticancer Res. (2006) [Pubmed]
Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs. Nishimura, S., Tsuda, H., Ito, K., Jobo, T., Yaegashi, N., Inoue, T., Sudo, T., Berkowitz, R.S., Mok, S.C. Hum. Pathol. (2007) [Pubmed]
Gender differences in the attainment of motor skills on the Movement Assessment Battery for Children. Junaid, K.A., Fellowes, S. Physical & occupational therapy in pediatrics. (2006) [Pubmed]
Glucocorticoid and mineralocorticoid cross-talk with progesterone receptor to induce focal adhesion and growth inhibition in breast cancer cells. Leo, J.C., Guo, C., Woon, C.T., Aw, S.E., Lin, V.C. Endocrinology (2004) [Pubmed]
Distinct molecular pathways mediate progesterone-induced growth inhibition and focal adhesion. Lin, V.C., Woon, C.T., Aw, S.E., Guo, C. Endocrinology (2003) [Pubmed]
Metallothionein 1E mRNA is highly expressed in oestrogen receptor-negative human invasive ductal breast cancer. Jin, R., Bay, B.H., Chow, V.T., Tan, P.H., Lin, V.C. Br. J. Cancer (2000) [Pubmed]

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