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Gene Review

RNF41  -  ring finger protein 41, E3 ubiquitin...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase NRDP1, FLRF, NRDP1, RING finger protein 41, SBBI03
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Disease relevance of RNF41


High impact information on RNF41


Biological context of RNF41


Associations of RNF41 with chemical compounds


Physical interactions of RNF41


Regulatory relationships of RNF41


Other interactions of RNF41


Analytical, diagnostic and therapeutic context of RNF41

  • Using affinity chromatography, we identified the deubiquitinating enzyme USP8 (also called Ubpy) as a protein that physically interacts with Nrdp1 [4].
  • Nrdp1 belongs to the tripartite or RBCC (RING, B-box, coiled-coil) family of ubiquitin ligases in which the RING domain is responsible for ubiquitin ligation and a variable C-terminal region mediates substrate recognition [7].


  1. Loss of Nrdp1 Enhances ErbB2/ErbB3-Dependent Breast Tumor Cell Growth. Yen, L., Cao, Z., Wu, X., Ingalla, E.R., Baron, C., Young, L.J., Gregg, J.P., Cardiff, R.D., Borowsky, A.D., Sweeney, C., Carraway, K.L. Cancer Res. (2006) [Pubmed]
  2. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. Qiu, X.B., Markant, S.L., Yuan, J., Goldberg, A.L. EMBO J. (2004) [Pubmed]
  3. An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. Diamonti, A.J., Guy, P.M., Ivanof, C., Wong, K., Sweeney, C., Carraway, K.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Wu, X., Yen, L., Irwin, L., Sweeney, C., Carraway, K.L. Mol. Cell. Biol. (2004) [Pubmed]
  5. Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8). Avvakumov, G.V., Walker, J.R., Xue, S., Finerty, P.J., Mackenzie, F., Newman, E.M., Dhe-Paganon, S. J. Biol. Chem. (2006) [Pubmed]
  6. RING finger ubiquitin-protein isopeptide ligase Nrdp1/FLRF regulates parkin stability and activity. Zhong, L., Tan, Y., Zhou, A., Yu, Q., Zhou, J. J. Biol. Chem. (2005) [Pubmed]
  7. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. Bouyain, S., Leahy, D.J. Protein Sci. (2007) [Pubmed]
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