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Gene Review

kpsD  -  KpsD protein

Escherichia coli CFT073

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Disease relevance of kpsD


High impact information on kpsD

  • Collectively the data suggest that the trans-periplasmic export involves KpsD acting as the link between the cytoplasmic membrane transporter and the outer membrane with KpsE acting to facilitate this transport process [2].
  • In addition, we demonstrate that KpsD is present not only within the periplasm but is also in both the cytoplasmic and outer membrane fractions and that the correct membrane association of KpsD was dependent on KpsE, Lpp, and the secreted polysaccharide molecule [2].
  • We demonstrate that KpsD and KpsE are located at the poles of the cell and that polysaccharide biosynthesis and export occurs at these polar sites [3].
  • Limiting-dilution reverse-transcribed PCRs confirmed down-regulation of the kpsD gene, and Northern blot and lacZ fusion analyses showed down-regulation of the kpsFEDUCS region 1 operon [1].
  • The nucleotide sequence of the 2.4-kb BamHI-PstI fragment accommodating the kpsD gene was determined [4].

Associations of kpsD with chemical compounds

  • Cells harboring a Tn1000 insertion in kpsD did not synthesize the 60-kilodalton protein and did not express polysaccharide on the cell surface [5].

Analytical, diagnostic and therapeutic context of kpsD


  1. Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors. Schwan, W.R., Beck, M.T., Hultgren, S.J., Pinkner, J., Woolever, N.L., Larson, T. Infect. Immun. (2005) [Pubmed]
  2. The transport of group 2 capsular polysaccharides across the periplasmic space in Escherichia coli. Roles for the KpsE and KpsD proteins. Arrecubieta, C., Hammarton, T.C., Barrett, B., Chareonsudjai, S., Hodson, N., Rainey, D., Roberts, I.S. J. Biol. Chem. (2001) [Pubmed]
  3. The cell surface expression of group 2 capsular polysaccharides in Escherichia coli: the role of KpsD, RhsA and a multi-protein complex at the pole of the cell. McNulty, C., Thompson, J., Barrett, B., Lord, L., Andersen, C., Roberts, I.S. Mol. Microbiol. (2006) [Pubmed]
  4. Nucleotide sequence and mutational analysis of the gene encoding KpsD, a periplasmic protein involved in transport of polysialic acid in Escherichia coli K1. Wunder, D.E., Aaronson, W., Hayes, S.F., Bliss, J.M., Silver, R.P. J. Bacteriol. (1994) [Pubmed]
  5. Translocation of capsular polysaccharides in pathogenic strains of Escherichia coli requires a 60-kilodalton periplasmic protein. Silver, R.P., Aaronson, W., Vann, W.F. J. Bacteriol. (1987) [Pubmed]
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