Disease relevance of Vangl1

• Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein [1].
• Moreover, siRNA targeting of KITENIN can function as a chemotherapeutic strategy against colon cancer [1].
• KITENIN promotes invasion of mouse colon adenocarcinoma (CT-26) cells in vivo [1].
• Ocular albinism type I (OA1) is an X-linked disorder characterized by severe reduction of visual acuity, strabismus, photophobia and nystagmus [2].
• Mucolipidosis type IV is an autosomal recessive lysosomal storage disorder characterized by severe neurodegeneration, achlorhydria, and visual impairments such as corneal opacity and strabismus [3].

Psychiatry related information on Vangl1

• The most common findings in this disorder are nonprogressive ataxia, strabismus, mental retardation, and speech delay with dysarthria [4].

High impact information on Vangl1

• Most forms of strabismus are multifactorial in origin; although there is probably an inherited component, the genetics of these disorders remain unclear [5].
• The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos [6].
• 90K was increased in the culture medium from CT-26/antisense KITENIN/90K cells [1].
• Moreover, increased levels of KITENIN were observed in a human gastric tumor and its metastatic tissues, compared with the normal adjacent mucosa [7].
• Studies in model organisms indicate that Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in regulating convergent extension (CE) movements during embryogenesis [8].

Biological context of Vangl1

• Differentiation of 3T3F442A preadipocytes into adipocytes led to an 80% reduction in ecto-LPA phosphatase activity, with a concomitant down-regulation in Lpp1, Lpp2, and Lpp3 mRNA expression [9].
• Recent studies using a mouse model of colon cancer, have suggested that KITENIN might be a metastasis enhancer whose functions are modulated by an interaction with KAI1/CD82 [10].

Anatomical context of Vangl1

• To begin to elucidate the mechanisms of PCP in vertebrates, the localization of the protein Vangl2 (Van Gogh-like) was determined during the development of the mammalian cochlea [11].

Other interactions of Vangl1

• Vangl1 and Prickle1 had expression canvases different from each other and from other candidates, indicating unrelated function [12].

References