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Gene Review

STAG3  -  stromal antigen 3

Homo sapiens

Synonyms: Cohesin subunit SA-3, SCC3 homolog 3, Stromal antigen 3, Stromalin-3
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Disease relevance of STAG3


High impact information on STAG3

  • We have mapped the human STAG3 gene to the 7q22 region of chromosome 7; six human STAG3-related genes have also been mapped: two at 7q22 near the functional gene, one at 7q11.22, and three at 7q11.23, two of them flanking the breakpoints commonly associated with the Williams-Beuren syndrome (WBS) deletion [1].
  • STAG3 is expressed specifically in testis, and immunolocalization experiments show that STAG3 is associated to the synaptonemal complex [1].
  • Since the WBS deletion occurs as a consequence of unequal meiotic crossing over, we suggest that STAG3 duplications predispose to germline chromosomal rearrangement within this region [1].
  • Immunofluorescence results suggest that a cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis [2].
  • In normal and atretic human fetal oocytes, from leptotene to diplotene stages, REC8 and STAG3 colocalize in fibers [3].

Anatomical context of STAG3


  1. STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion. Pezzi, N., Prieto, I., Kremer, L., Pérez Jurado, L.A., Valero, C., Del Mazo, J., Martínez-A, C., Barbero, J.L. FASEB J. (2000) [Pubmed]
  2. STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. Prieto, I., Pezzi, N., Buesa, J.M., Kremer, L., Barthelemy, I., Carreiro, C., Roncal, F., Martinez, A., Gomez, L., Fernandez, R., Martinez-A, C., Barbero, J.L. EMBO Rep. (2002) [Pubmed]
  3. Cohesin component dynamics during meiotic prophase I in mammalian oocytes. Prieto, I., Tease, C., Pezzi, N., Buesa, J.M., Ortega, S., Kremer, L., Martínez, A., Martínez-A, C., Hultén, M.A., Barbero, J.L. Chromosome Res. (2004) [Pubmed]
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