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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SMC1B  -  structural maintenance of chromosomes 1B

Homo sapiens

Synonyms: SMC protein 1B, SMC-1-beta, SMC-1B, SMC1BETA, SMC1L2, ...
 
 
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High impact information on SMC1B

  • (2005) show that mice with a mutation in the meiosis-specific cohesin protein SMC1beta exhibit age-dependent defects in meiosis [1].
  • Their results implicate an age-dependent loss of function in SMC1beta (or related proteins) in the maternal age effect of humans [1].
  • Most SMC1beta dissociates from the chromosome arms in late-pachytene-diplotene cells [2].
  • SMC1beta is specifically expressed in testes and coimmunoprecipitates with SMC3 from testis nuclear extracts, but not from a variety of somatic cells [2].
  • However, SMC1beta, but not SMC1alpha, remains chromatin associated at the centromeres up to metaphase II [2].
 

Biological context of SMC1B

  • Thus, SMC1beta and not SMC1alpha is likely involved in maintaining cohesion between sister centromeres until anaphase II [2].
 

Anatomical context of SMC1B

  • Three meiosis-specific cohesin subunits have been reported in mammals, REC8, STAG3 and SMC1 beta; their expression in mouse spermatocytes has also been described [3].
  • Analysis of testis sections and chromosome spreads of various stages of meiosis revealed localization of SMC1beta along the axial elements of synaptonemal complexes in prophase I [2].

References

  1. Cohesin and the maternal age effect. Gilliland, W.D., Hawley, R.S. Cell (2005) [Pubmed]
  2. Novel meiosis-specific isoform of mammalian SMC1. Revenkova, E., Eijpe, M., Heyting, C., Gross, B., Jessberger, R. Mol. Cell. Biol. (2001) [Pubmed]
  3. Cohesin component dynamics during meiotic prophase I in mammalian oocytes. Prieto, I., Tease, C., Pezzi, N., Buesa, J.M., Ortega, S., Kremer, L., Martínez, A., Martínez-A, C., Hultén, M.A., Barbero, J.L. Chromosome Res. (2004) [Pubmed]
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