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Gene Review

Cyp3a11  -  cytochrome P450, family 3, subfamily a,...

Mus musculus

Synonyms: AI256190, CYPIIIA11, Cyp3a, Cyp3a-11, Cytochrome P-450IIIAM1, ...
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High impact information on Cyp3a11


Biological context of Cyp3a11


Anatomical context of Cyp3a11


Associations of Cyp3a11 with chemical compounds


Enzymatic interactions of Cyp3a11


Other interactions of Cyp3a11


Analytical, diagnostic and therapeutic context of Cyp3a11

  • We have used a specific anti-PXR antibody in the Western blotting of mouse liver nuclear extracts to show that PXR is accumulated in the nucleus after treatment with 5-pregnen-3beta-ol-20-one-16alpha-carbonitrile (PCN), followed by an increase in Cyp3a11 mRNA [20].
  • Adrenalectomy did not prevent the loss in Cyp3a11 expression or activity, thereby precluding the involvement of the hypothalamic-adrenal-pituitary axis [21].
  • Peripheral administration of 2.5 microg LPS by intraperitoneal injection produced similar serum endotoxin levels and a similar loss (60%) in Cyp3a11 expression and activity in the liver [21].


  1. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Wagner, M., Halilbasic, E., Marschall, H.U., Zollner, G., Fickert, P., Langner, C., Zatloukal, K., Denk, H., Trauner, M. Hepatology (2005) [Pubmed]
  2. Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Wiwi, C.A., Gupte, M., Waxman, D.J. Mol. Endocrinol. (2004) [Pubmed]
  3. Transcriptional Repression of Hepatic Cytochrome P450 3A4 Gene in the Presence of Cancer. Charles, K.A., Rivory, L.P., Brown, S.L., Liddle, C., Clarke, S.J., Robertson, G.R. Clin. Cancer Res. (2006) [Pubmed]
  4. Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice. Kluth, D., Landes, N., Pfluger, P., Müller-Schmehl, K., Weiss, K., Bumke-Vogt, C., Ristow, M., Brigelius-Flohé, R. Free Radic. Biol. Med. (2005) [Pubmed]
  5. Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice. Hernandez, J.P., Chapman, L.M., Kretschmer, X.C., Baldwin, W.S. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  6. A map of the mouse Cyp3a locus. Zaphiropoulos, P.G. DNA Seq. (2003) [Pubmed]
  7. Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. Marschall, H.U., Wagner, M., Bodin, K., Zollner, G., Fickert, P., Gumhold, J., Silbert, D., Fuchsbichler, A., Sjövall, J., Trauner, M. J. Lipid Res. (2006) [Pubmed]
  8. Gene structure of mouse Cyp3a11: evidence for an enhancer element within its 5' flanking sequences. Toide, K., Itoh, S., Nagasaka, Y., Yanagimoto, T., Kamataki, T. Arch. Biochem. Biophys. (1997) [Pubmed]
  9. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor. Ding, X., Lichti, K., Staudinger, J.L. Toxicol. Sci. (2006) [Pubmed]
  10. Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1. Yanagimoto, T., Itoh, S., Sawada, M., Kamataki, T. Arch. Biochem. Biophys. (1997) [Pubmed]
  11. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075). Riley, R.J., Hemingway, S.A., Graham, M.A., Workman, P. Biochem. Pharmacol. (1993) [Pubmed]
  12. Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. Yamazaki, H., Iketaki, H., Shibata, A., Nakajima, M., Yokoi, T. Drug Metab. Pharmacokinet. (2002) [Pubmed]
  13. Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver. Pan, J., Xiang, Q., Ball, S. Drug Metab. Dispos. (2000) [Pubmed]
  14. Induction of hepatic cyp2b and cyp3a subfamily enzymes by nicardipine and nifedipine in mice. Konno, Y., Sekimoto, M., Nemoto, K., Degawa, M. Xenobiotica (2004) [Pubmed]
  15. Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-{alpha}/beta in the adaptive response to bile acids. Zollner, G., Wagner, M., Moustafa, T., Fickert, P., Silbert, D., Gumhold, J., Fuchsbichler, A., Halilbasic, E., Denk, H., Marschall, H.U., Trauner, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  16. Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice. Sun, G., Thai, S.F., Lambert, G.R., Wolf, D.C., Tully, D.B., Goetz, A.K., George, M.H., Grindstaff, R.D., Dix, D.J., Nesnow, S. Toxicol. Lett. (2006) [Pubmed]
  17. Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: assessment using aromatase-deficient mice. Yamada, H., Gohyama, N., Honda, S., Hara, T., Harada, N., Oguri, K. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  18. CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. Anakk, S., Kalsotra, A., Kikuta, Y., Huang, W., Zhang, J., Staudinger, J.L., Moore, D.D., Strobel, H.W. Pharmacogenomics J. (2004) [Pubmed]
  19. Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control. Itoh, S., Abe, Y., Kubo, A., Okuda, M., Shimoji, M., Nakayama, K., Kamataki, T. Biochim. Biophys. Acta (1997) [Pubmed]
  20. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. Squires, E.J., Sueyoshi, T., Negishi, M. J. Biol. Chem. (2004) [Pubmed]
  21. Toll-like receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation. Goralski, K.B., Abdulla, D., Sinal, C.J., Arsenault, A., Renton, K.W. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
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