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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Dob1  -  dietary obesity 1

Mus musculus

Synonyms: Do1
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Disease relevance of Dob1


High impact information on Dob1


Biological context of Dob1


Anatomical context of Dob1

  • We recently reported that UCP2 expression is increased by high fat feeding in adipose tissue of the A/J strain of mice, which is resistant to the development of dietary obesity [8].

Associations of Dob1 with chemical compounds

  • In one model of dietary obesity resulting when animals eat a high-fat diet, the syndrome is blocked by inhibitory adrenal steroid activity [9].

Other interactions of Dob1

  • CONCLUSIONS: Impaired expression of adipocyte betaAR subtypes is a general feature of both genetic and dietary obesity in mice [10].
  • Indeed, mice deficient in 11beta-HSD1 resist both the metabolic syndrome that develops with dietary obesity and glucocorticoid-associated cognitive impairments that develop with ageing [11].
  • Obese human and rodent models of dietary obesity have shown decreased sensitivity to blood-borne leptin, postulated to be due to impaired transport of leptin across the BBB [12].


  1. Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. West, D.B., Waguespack, J., York, B., Goudey-Lefevre, J., Price, R.A. Mamm. Genome (1994) [Pubmed]
  2. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Scheja, L., Makowski, L., Uysal, K.T., Wiesbrock, S.M., Shimshek, D.R., Meyers, D.S., Morgan, M., Parker, R.A., Hotamisligil, G.S. Diabetes (1999) [Pubmed]
  3. Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. Koza, R.A., Hohmann, S.M., Guerra, C., Rossmeisl, M., Kozak, L.P. J. Biol. Chem. (2000) [Pubmed]
  4. Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Sleeman, M.W., Wortley, K.E., Lai, K.M., Gowen, L.C., Kintner, J., Kline, W.O., Garcia, K., Stitt, T.N., Yancopoulos, G.D., Wiegand, S.J., Glass, D.J. Nat. Med. (2005) [Pubmed]
  5. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Hotamisligil, G.S., Johnson, R.S., Distel, R.J., Ellis, R., Papaioannou, V.E., Spiegelman, B.M. Science (1996) [Pubmed]
  6. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. West, D.B., Goudey-Lefevre, J., York, B., Truett, G.E. J. Clin. Invest. (1994) [Pubmed]
  7. Inactivation of PKC{theta} leads to increased susceptibility to obesity and dietary insulin resistance in mice. Gao, Z., Wang, Z., Zhang, X., Butler, A.A., Zuberi, A., Gawronska-Kozak, B., Lefevre, M., York, D., Ravussin, E., Berthoud, H.R., McGuinness, O., Cefalu, W.T., Ye, J. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  8. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. Surwit, R.S., Wang, S., Petro, A.E., Sanchis, D., Raimbault, S., Ricquier, D., Collins, S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. The MONA LISA hypothesis in the time of leptin. Bray, G.A., York, D.A. Recent Prog. Horm. Res. (1998) [Pubmed]
  10. Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. Collins, S., Daniel, K.W., Rohlfs, E.M. Int. J. Obes. Relat. Metab. Disord. (1999) [Pubmed]
  11. 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory. Seckl, J.R., Walker, B.R. Trends Endocrinol. Metab. (2004) [Pubmed]
  12. Impaired transport of leptin across the blood-brain barrier in obesity. Banks, W.A., DiPalma, C.R., Farrell, C.L. Peptides (1999) [Pubmed]
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