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Gene Review

Hsd11b1  -  hydroxysteroid 11-beta dehydrogenase 1

Mus musculus

Synonyms: 11-DH, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11beta-HSD-1, 11beta-HSD1A, ...
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Disease relevance of Hsd11b1


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Chemical compound and disease context of Hsd11b1


Biological context of Hsd11b1


Anatomical context of Hsd11b1


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Regulatory relationships of Hsd11b1


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Analytical, diagnostic and therapeutic context of Hsd11b1


  1. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Liu, Y., Nakagawa, Y., Wang, Y., Li, R., Li, X., Ohzeki, T., Friedman, T.C. Diabetes (2003) [Pubmed]
  2. Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. Gilmour, J.S., Coutinho, A.E., Cailhier, J.F., Man, T.Y., Clay, M., Thomas, G., Harris, H.J., Mullins, J.J., Seckl, J.R., Savill, J.S., Chapman, K.E. J. Immunol. (2006) [Pubmed]
  3. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. Morton, N.M., Holmes, M.C., Fiévet, C., Staels, B., Tailleux, A., Mullins, J.J., Seckl, J.R. J. Biol. Chem. (2001) [Pubmed]
  4. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Morton, N.M., Paterson, J.M., Masuzaki, H., Holmes, M.C., Staels, B., Fievet, C., Walker, B.R., Flier, J.S., Mullins, J.J., Seckl, J.R. Diabetes (2004) [Pubmed]
  5. Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo. De Sousa Peixoto, R.A., Turban, S., Battle, J.H., Chapman, K.E., Seckl, J.R., Morton, N.M. Endocrinology (2008) [Pubmed]
  6. 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. Wamil, M., Andrew, R., Chapman, K.E., Street, J., Morton, N.M., Seckl, J.R. Endocrinology (2008) [Pubmed]
  7. Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development. Speirs, H.J., Seckl, J.R., Brown, R.W. J. Endocrinol. (2004) [Pubmed]
  8. Active catabolism of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase in vivo is a necessary requirement for natural resistance to infection with Listeria monocytogenes. Hennebold, J.D., Mu, H.H., Poynter, M.E., Chen, X.P., Daynes, R.A. Int. Immunol. (1997) [Pubmed]
  9. A transgenic model of visceral obesity and the metabolic syndrome. Masuzaki, H., Paterson, J., Shinyama, H., Morton, N.M., Mullins, J.J., Seckl, J.R., Flier, J.S. Science (2001) [Pubmed]
  10. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. Masuzaki, H., Yamamoto, H., Kenyon, C.J., Elmquist, J.K., Morton, N.M., Paterson, J.M., Shinyama, H., Sharp, M.G., Fleming, S., Mullins, J.J., Seckl, J.R., Flier, J.S. J. Clin. Invest. (2003) [Pubmed]
  11. Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. Kotelevtsev, Y., Brown, R.W., Fleming, S., Kenyon, C., Edwards, C.R., Seckl, J.R., Mullins, J.J. J. Clin. Invest. (1999) [Pubmed]
  12. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Alberts, P., Engblom, L., Edling, N., Forsgren, M., Klingström, G., Larsson, C., Rönquist-Nii, Y., Ohman, B., Abrahmsén, L. Diabetologia (2002) [Pubmed]
  13. Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease. Walker, B.R., Andrew, R. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  14. Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH. Agarwal, A.K. Endocr. Res. (2003) [Pubmed]
  15. Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. Stulnig, T.M., Oppermann, U., Steffensen, K.R., Schuster, G.U., Gustafsson, J.A. Diabetes (2002) [Pubmed]
  16. Spatial and temporal patterns of expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 messenger RNA and glucocorticoid receptor protein in the murine placenta and uterus during late pregnancy. Thompson, A., Han, V.K., Yang, K. Biol. Reprod. (2002) [Pubmed]
  17. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Kotelevtsev, Y., Holmes, M.C., Burchell, A., Houston, P.M., Schmoll, D., Jamieson, P., Best, R., Brown, R., Edwards, C.R., Seckl, J.R., Mullins, J.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. The expression of 11 beta-hydroxysteroid dehydrogenase type I by lymphocytes provides a novel means for intracrine regulation of glucocorticoid activities. Zhang, T.Y., Ding, X., Daynes, R.A. J. Immunol. (2005) [Pubmed]
  19. Liver X Receptor Agonist T0901317 Inhibition of Glucocorticoid Receptor Expression in Hepatocytes May Contribute to the Amelioration of Diabetic Syndrome in db/db Mice. Liu, Y., Yan, C., Wang, Y., Nakagawa, Y., Nerio, N., Anghel, A., Lutfy, K., Friedman, T.C. Endocrinology (2006) [Pubmed]
  20. Differential expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. Thompson, A., Han, V.K., Yang, K. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
  21. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Liu, Y., Nakagawa, Y., Wang, Y., Sakurai, R., Tripathi, P.V., Lutfy, K., Friedman, T.C. Diabetes (2005) [Pubmed]
  22. Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. Hult, M., Elleby, B., Shafqat, N., Svensson, S., Rane, A., Jörnvall, H., Abrahmsen, L., Oppermann, U. Cell. Mol. Life Sci. (2004) [Pubmed]
  23. 11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function. Walker, E.A., Ahmed, A., Lavery, G.G., Tomlinson, J.W., Kim, S.Y., Cooper, M.S., Ride, J.P., Hughes, B.A., Shackleton, C.H., McKiernan, P., Elias, E., Chou, J.Y., Stewart, P.M. J. Biol. Chem. (2007) [Pubmed]
  24. Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice. Paterson, J.M., Holmes, M.C., Kenyon, C.J., Carter, R., Mullins, J.J., Seckl, J.R. Endocrinology (2007) [Pubmed]
  25. 11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. Swali, A., Walker, E.A., Lavery, G.G., Tomlinson, J.W., Stewart, P.M. Diabetologia (2008) [Pubmed]
  26. Regulation of 11beta-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans. Ortsäter, H., Alberts, P., Warpman, U., Engblom, L.O., Abrahmsén, L., Bergsten, P. Diabetes Metab. Res. Rev. (2005) [Pubmed]
  27. Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity. Berger, J., Tanen, M., Elbrecht, A., Hermanowski-Vosatka, A., Moller, D.E., Wright, S.D., Thieringer, R. J. Biol. Chem. (2001) [Pubmed]
  28. Coordinate regulation of 11 beta-HSD and Ke 6 genes in cpk mouse: implications for steroid metabolic defect in PKD. Aziz, N., Maxwell, M.M., Brenner, B.M. Am. J. Physiol. (1994) [Pubmed]
  29. Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance. Asensio, C., Muzzin, P., Rohner-Jeanrenaud, F. Int. J. Obes. Relat. Metab. Disord. (2004) [Pubmed]
  30. Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease. Morton, N.M., Ramage, L., Seckl, J.R. Endocrinology (2004) [Pubmed]
  31. Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes. Holmes, M.C., Kotelevtsev, Y., Mullins, J.J., Seckl, J.R. Mol. Cell. Endocrinol. (2001) [Pubmed]
  32. Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone. Sher, L.B., Woitge, H.W., Adams, D.J., Gronowicz, G.A., Krozowski, Z., Harrison, J.R., Kream, B.E. Endocrinology (2004) [Pubmed]
  33. 11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase. Maser, E., Völker, B., Friebertshäuser, J. Biochemistry (2002) [Pubmed]
  34. Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA. Rajan, V., Chapman, K.E., Lyons, V., Jamieson, P., Mullins, J.J., Edwards, C.R., Seckl, J.R. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  35. Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice. Hundertmark, S., Dill, A., Ebert, A., Zimmermann, B., Kotelevtsev, Y.V., Mullins, J.J., Seckl, J.R. Horm. Metab. Res. (2002) [Pubmed]
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