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Vimp  -  VCP-interacting membrane protein

Mus musculus

Synonyms: 1500011E07Rik, C78786, H-4, H-47, H4, ...
 
 
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High impact information on H47

  • In contrast, the apparent binding sites of antibodies (Hiei and H47) that selectively inhibit high-affinity IL-2 binding were mapped to a distinct location (residues 158-160) within the region encoded by exon 4 of the Tac gene [1].
  • Cell cycle regulation of a mouse histone H4 gene requires the H4 promoter [2].
  • The mouse histone H4 gene, when stably transformed into L cells on the PSV2gpt shuttle vector, is cell cycle regulated in parallel with the endogenous H4 genes [2].
  • There are three histone H3 genes, two of which are identical; four histone H2a genes, two of which are identical, one histone H4 gene; and two histone H2b genes [3].
  • Distinguishing self from nonself: immunogenicity of the murine H47 locus is determined by a single amino acid substitution in an unusual peptide [4].
 

Biological context of H47

  • Here we defined the molecular basis of self-nonself discrimination for the murine chromosome 7 encoded H47 histocompatibility locus, known by its trait of graft-rejection for over 40 years [4].
  • Based on results with the CSFV epitope and two porcine haplotypes (H4 and H7), the in vitro refold assay appeared able to discriminate between peptide-free and peptide-occupied forms of SLA-I [5].
 

Anatomical context of H47

  • H47 mAb, however, failed to enhance T cell proliferation induced by anti-CD3 mAb, anti-CD2 mAb, or phytohemagglutinin (PHA) [6].
  • H47 mAb respectively immunoprecipitated a 100 or 120-kD molecular weight (MW) membrane protein of T cells and monocytes under nonreducing or reducing conditions, suggesting that H47 Ag consists of a single polypeptide that has intramolecular disulfide bonds [6].
  • A novel antigen (H47 Ag) on human lymphocytes involved in T cell activation [6].
  • The extracellular domains of swine leukocyte antigen class I (SLA-I, major histocompatibility complex protein class I) were cloned and sequenced for two haplotypes (H4 and H7) which do not share any alleles based on serological typing, and which are the most important in Danish farmed pigs [5].
 

Other interactions of H47

  • The functional significance of a minor H congenic strain differing by both TH-defined H-46 and CTL-defined H-47 was addressed using F1 complementation tests [7].
 

Analytical, diagnostic and therapeutic context of H47

  • This hypothesis was tested by transplanting recipients with 10 sets of H4-incompatible skin allografts that were harvested at times of rejection for spectratyping of TCR alpha and beta transcripts expressed by graft-infiltrating T cells [8].

References

  1. Structure-function relationships for the interleukin 2 receptor: location of ligand and antibody binding sites on the Tac receptor chain by mutational analysis. Robb, R.J., Rusk, C.M., Neeper, M.P. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  2. Cell cycle regulation of a mouse histone H4 gene requires the H4 promoter. Seiler-Tuyns, A., Paterson, B.M. Mol. Cell. Biol. (1987) [Pubmed]
  3. Characterization of the 55-kb mouse histone gene cluster on chromosome 3. Wang, Z.F., Tisovec, R., Debry, R.W., Frey, M.R., Matera, A.G., Marzluff, W.F. Genome Res. (1996) [Pubmed]
  4. Distinguishing self from nonself: immunogenicity of the murine H47 locus is determined by a single amino acid substitution in an unusual peptide. Mendoza, L.M., Villaflor, G., Eden, P., Roopenian, D., Shastri, N. J. Immunol. (2001) [Pubmed]
  5. Development of a rapid in vitro protein refolding assay which discriminates between peptide-bound and peptide-free forms of recombinant porcine major histocompatibility class I complex (SLA-I). Oleksiewicz, M.B., Kristensen, B., Ladekjaer-Mikkelsen, A.S., Nielsen, J. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  6. A novel antigen (H47 Ag) on human lymphocytes involved in T cell activation. Hirohashi, N., Nakao, M., Kubo, K., Yamada, A., Shichijo, S., Hara, A., Sagawa, K., Itoh, K. Cell. Immunol. (1993) [Pubmed]
  7. Complexity at the mouse minor histocompatibility locus H-4. Davis, A.P., Roopenian, D.C. Immunogenetics (1990) [Pubmed]
  8. Repertoires of T cell receptors expressed by graft-infiltrating T cells evolve during long-term recall responses to single minor histocompatibility antigens. Wettstein, P.J., Strausbauch, M., Borson, N. Int. Immunol. (2007) [Pubmed]
 
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