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Gene Review:

Cea - carcinoembryonic antigen gene family

Mus musculus

Nédellec, P. et al., Dveksler, G.S. et al., Chen, D.S. et al., Rettenberger, G. et al., Finkenzeller, D. et al., et al.

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Disease relevance of Cea

Murine coronaviruses such as mouse hepatitis virus (MHV) infect mouse cells via cellular receptors that are isoforms of biliary glycoprotein (Bgp) of the carcinoembryonic antigen gene family (G. S. Dveksler, C. W. Dieffenbach, C. B. Cardellichio, K. McCuaig, M. N. Pensiero, G.-S. Jiang, N. Beauchemin, and K. V. Holmes, J. Virol. 67:1-8, 1993) [1].

High impact information on Cea

By low-stringency screening of a mouse brain cDNA library, we have identified a member of the pregnancy-specific glycoprotein (PSG) subgroup of the carcinoembryonic antigen gene family [2].
The variant and parent cell line were characterized with respect to morphology, growth characteristics, karyotype, production of Cea, and ability to form tumors in nude mice [3].
cea5, a structurally divergent member of the murine carcinoembryonic antigen gene family, is exclusively expressed during early placental development in trophoblast giant cells [4].
A mouse carcinoembryonic antigen gene family member is a calcium-dependent cell adhesion molecule [5].
The sequence of this clone predicts a 424-amino-acid glycoprotein with four immunoglobulinlike domains, a transmembrane domain, and a short intracytoplasmic tail, MHVR1 is closely related to the murine CEA-related clone mmCGM1 (Mus musculus carcinoembryonic antigen gene family member) [6].

Biological context of Cea

mmCGM1a: a mouse carcinoembryonic antigen gene family member, generated by alternative splicing, functions as an adhesion molecule [7].
The genes for the pregnancy-specific glycoproteins Cea2 and Cea4, both belonging to the large carcinoembryonic antigen gene family, were localized by chromosomal in situ suppression hybridization of three YAC clones to murine chromosome 7A2-A3 [8].

Other interactions of Cea

Eight of 9 new expressible genes (Ceacam12-Ceacam20) could be located within the approximately 6.5-Mb murine Cea locus [9].

References

Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. Nédellec, P., Dveksler, G.S., Daniels, E., Turbide, C., Chow, B., Basile, A.A., Holmes, K.V., Beauchemin, N. J. Virol. (1994) [Pubmed]
A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus. Chen, D.S., Asanaka, M., Yokomori, K., Wang, F., Hwang, S.B., Li, H.P., Lai, M.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Variants of a human colon adenocarcinoma cell line which differ in morphology and carcinoembryonic antigen production. Rosenthal, K.L., Tompkins, W.A., Frank, G.L., McCulloch, P., Rawls, W.E. Cancer Res. (1977) [Pubmed]
cea5, a structurally divergent member of the murine carcinoembryonic antigen gene family, is exclusively expressed during early placental development in trophoblast giant cells. Finkenzeller, D., Kromer, B., Thompson, J., Zimmermann, W. J. Biol. Chem. (1997) [Pubmed]
A mouse carcinoembryonic antigen gene family member is a calcium-dependent cell adhesion molecule. Turbide, C., Rojas, M., Stanners, C.P., Beauchemin, N. J. Biol. Chem. (1991) [Pubmed]
Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. Dveksler, G.S., Pensiero, M.N., Cardellichio, C.B., Williams, R.K., Jiang, G.S., Holmes, K.V., Dieffenbach, C.W. J. Virol. (1991) [Pubmed]
mmCGM1a: a mouse carcinoembryonic antigen gene family member, generated by alternative splicing, functions as an adhesion molecule. McCuaig, K., Turbide, C., Beauchemin, N. Cell Growth Differ. (1992) [Pubmed]
Mapping of murine YACs containing the genes Cea2 and Cea4 after B1-PCR amplification and FISH-analysis. Rettenberger, G., Zimmermann, W., Klett, C., Zechner, U., Hameister, H. Chromosome Res. (1995) [Pubmed]
Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. Zebhauser, R., Kammerer, R., Eisenried, A., McLellan, A., Moore, T., Zimmermann, W. Genomics (2005) [Pubmed]

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