Gene Review:
SMAD7 - SMAD family member 7
Homo sapiens
Synonyms:
CRCS3, MAD homolog 7, MAD homolog 8, MADH7, MADH8, ...
Reuter,
Karatsaidis,
Lowy,
Sommer,
Martinoli,
Terracciano,
Samantha Dewundara,
Schenck,
Jason Churchill,
Paul C. Kogut,
Blanca Camoretti-Mercado,
Lowy,
Tomi,
Darren J. Fernandes,
Topouzis,
Julian Solway,
Metzger,
Hyun,
Liang,
Boulay,
Boulay,
Laffer,
Gambichler,
Dittmer,
Stotish,
Lindemann,
Stamm,
Rochlitz,
Michael S. Parmacek,
Rochlitz,
Zhu,
Herrmann,
Schreurs,
Helgeland,
Reuter,
Skrygan,
Kreuter,
Mild,
John F. McConville,
Laffer,
Mild,
Lan Ma,
Lagrange,
Axéll,
Lagrange,
Orth,
Herrmann,
Nordheim,
Altmeyer,
Terracciano,
Breuckmann,
- Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7. Boulay, J.L., Mild, G., Reuter, J., Lagrange, M., Terracciano, L., Lowy, A., Laffer, U., Orth, B., Metzger, U., Stamm, B., Martinoli, S., Herrmann, R., Rochlitz, C. Genes Chromosomes Cancer (2001)
- Ultraviolet A1 phototherapy decreases inhibitory SMAD7 gene expression in localized scleroderma. Kreuter, A., Hyun, J., Skrygan, M., Sommer, A., Tomi, N.S., Breuckmann, F., Altmeyer, P., Gambichler, T. Arch. Dermatol. Res. (2006)
- Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring. Yu, H., Bock, O., Bayat, A., Ferguson, M.W., Mrowietz, U. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. (2006)
- Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein. Boyer Arnold, N., Korc, M. J. Biol. Chem. (2005)
- The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.Y., Grinnell, B.W., Richardson, M.A., Topper, J.N., Gimbrone, M.A., Wrana, J.L., Falb, D. Cell (1997)
- Control of Smad7 stability by competition between acetylation and ubiquitination. Grönroos, E., Hellman, U., Heldin, C.H., Ericsson, J. Mol. Cell (2002)
- Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Kavsak, P., Rasmussen, R.K., Causing, C.G., Bonni, S., Zhu, H., Thomsen, G.H., Wrana, J.L. Mol. Cell (2000)
- 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7. Davoodpour, P., Landström, M. J. Biol. Chem. (2005)
- Transforming growth factor-beta and Smad signalling in kidney diseases. Wang, W., Koka, V., Lan, H.Y. Nephrology (Carlton, Vic.) (2005)
- Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K., Iwamoto, I. J. Clin. Invest. (1999)
- Effects of perindopril and valsartan on expression of transforming growth factor-beta-Smads in experimental hepatic fibrosis in rats. Xu, W., Song, S., Huang, Y., Gong, Z. J. Gastroenterol. Hepatol. (2006)
- Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta. von Gersdorff, G., Susztak, K., Rezvani, F., Bitzer, M., Liang, D., Böttinger, E.P. J. Biol. Chem. (2000)
- TGF-beta Suppresses IFN-{gamma}-STAT1-Dependent Gene Transcription by Enhancing STAT1-PIAS1 Interactions in Epithelia but Not Monocytes/Macrophages. Reardon, C., McKay, D.M. J. Immunol. (2007)
- SMAD7 is a prognostic marker in patients with colorectal cancer. Boulay, J.L., Mild, G., Lowy, A., Reuter, J., Lagrange, M., Terracciano, L., Laffer, U., Herrmann, R., Rochlitz, C. Int. J. Cancer (2003)
- Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. Kopp, J., Preis, E., Said, H., Hafemann, B., Wickert, L., Gressner, A.M., Pallua, N., Dooley, S. J. Biol. Chem. (2005)
- Modulation of proliferation-specific and differentiation-specific markers in human keratinocytes by SMAD7. Smith, L., Dahler, A.L., Cavanagh, L.L., Popa, C., Barnes, L.M., Serewko-Auret, M.M., Fai Wong, C., Saunders, N.A. Exp. Cell Res. (2004)
- Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells. Landström, M., Heldin, N.E., Bu, S., Hermansson, A., Itoh, S., ten Dijke, P., Heldin, C.H. Curr. Biol. (2000)
- Inhibition of the transforming growth factor-beta/Smad signaling pathway in the epithelium of oral lichen. Karatsaidis, A., Schreurs, O., Axéll, T., Helgeland, K., Schenck, K. J. Invest. Dermatol. (2003)
- Phosphorylation regulation of the interaction between Smad7 and activin type I receptor. Liu, X., Nagarajan, R.P., Vale, W., Chen, Y. FEBS Lett. (2002)
- Beta-hydroxybutyrate-induced growth inhibition and collagen production in HK-2 cells are dependent on TGF-beta and Smad3. Guh, J.Y., Chuang, T.D., Chen, H.C., Hung, W.C., Lai, Y.H., Shin, S.J., Chuang, L.Y. Kidney Int. (2003)
- Role of TGF-beta signaling in extracellular matrix production under high glucose conditions. Li, J.H., Huang, X.R., Zhu, H.J., Johnson, R., Lan, H.Y. Kidney Int. (2003)
- Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially affects TGFbeta-dependent gene expression. Lindemann, R.K., Nordheim, A., Dittmer, J. Mol. Cancer (2003)
- Effect of IFN-gamma and dexamethasone on TGF-beta1-induced human fetal lung fibroblast-myofibroblast differentiation. Gu, L., Zhu, Y.J., Guo, Z.J., Xu, X.X., Xu, W.B. Acta Pharmacol. Sin. (2004)
- Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts. Quan, T., He, T., Voorhees, J.J., Fisher, G.J. J. Biol. Chem. (2005)
- Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. Denissova, N.G., Pouponnot, C., Long, J., He, D., Liu, F. Proc. Natl. Acad. Sci. U.S.A. (2000)
- SnoN co-repressor binds and represses smad7 gene promoter. Briones-Orta, M.A., Sosa-Garrocho, M., Moreno-Alvarez, P., Fonseca-Sánchez, M.A., Macías-Silva, M. Biochem. Biophys. Res. Commun. (2006)
- Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7. Camoretti-Mercado, B., Fernandes, D.J., Dewundara, S., Churchill, J., Ma, L., Kogut, P.C., McConville, J.F., Parmacek, M.S., Solway, J. J. Biol. Chem. (2006)
- Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. Morén, A., Imamura, T., Miyazono, K., Heldin, C.H., Moustakas, A. J. Biol. Chem. (2005)
- Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB. Nagarajan, R.P., Chen, F., Li, W., Vig, E., Harrington, M.A., Nakshatri, H., Chen, Y. Biochem. J. (2000)
- Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism. Zhu, X., Topouzis, S., Liang, L.F., Stotish, R.L. Cytokine (2004)
- Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Zhang, S., Fei, T., Zhang, L., Zhang, R., Chen, F., Ning, Y., Han, Y., Feng, X.H., Meng, A., Chen, Y.G. Mol. Cell. Biol. (2007)
- STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Datta, P.K., Moses, H.L. Mol. Cell. Biol. (2000)
- Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Mori, Y., Chen, S.J., Varga, J. Arthritis Rheum. (2003)
- The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Kleeff, J., Ishiwata, T., Maruyama, H., Friess, H., Truong, P., Büchler, M.W., Falb, D., Korc, M. Oncogene (1999)
- Differential expression of Smad7 transcripts identifies the CD4+CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts. Mizobuchi, T., Yasufuku, K., Zheng, Y., Haque, M.A., Heidler, K.M., Woods, K., Smith, G.N., Cummings, O.W., Fujisawa, T., Blum, J.S., Wilkes, D.S. J. Immunol. (2003)
- N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells. Kanasaki, K., Koya, D., Sugimoto, T., Isono, M., Kashiwagi, A., Haneda, M. J. Am. Soc. Nephrol. (2003)