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Gene Review

INMT  -  indolethylamine N-methyltransferase

Homo sapiens

Synonyms: Amine N-methyltransferase, Aromatic alkylamine N-methyltransferase, Arylamine N-methyltransferase, Indolamine N-methyltransferase, Indolethylamine N-methyltransferase, ...
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Disease relevance of INMT


Psychiatry related information on INMT


High impact information on INMT


Chemical compound and disease context of INMT


Biological context of INMT


Anatomical context of INMT


Associations of INMT with chemical compounds


Analytical, diagnostic and therapeutic context of INMT

  • Northern blot analysis of 35 tissues showed that a 2.7-kb INMT mRNA species was expressed in most tissues [7].



  1. Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation. Kim, Y.H., Joo, n.u.l.l. Exp. Mol. Med. (2001) [Pubmed]
  2. Plasma indolethylamine-n-methyltransferase activity and growth hormone level during sleep: a pilot study. Strahilevitz, M., Othmer, E., Narasimhachari, N., Othmer, S.C., Jacobs, L.S. Biol. Psychiatry (1977) [Pubmed]
  3. Rates of in vivo methylation of desipramine and nortriptyline. Kurpius, M.P., Alexander, B. Pharmacotherapy (2006) [Pubmed]
  4. Rabbit lung indolethylamine N-methyltransferase. cDNA and gene cloning and characterization. Thompson, M.A., Weinshilboum, R.M. J. Biol. Chem. (1998) [Pubmed]
  5. A test of the transmethylation hypothesis in acute schizophrenic patients. Carpenter, W.T., Fink, E.B., Narasimhachari, N., Himwich, H.E. The American journal of psychiatry. (1975) [Pubmed]
  6. Inhibitors of indoleethylamine N-methyltransferase. Derivatives of 3-methyl-2-thiazolidinimine. In vitro, in vivo, and metabolic studies. Rokach, J., Girard, Y., Hamel, P., Reader, G., Rooney, C.S., Mandel, L.R., Cragoe, E.J., Zacchei, A.G. J. Med. Chem. (1980) [Pubmed]
  7. Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. Thompson, M.A., Moon, E., Kim, U.J., Xu, J., Siciliano, M.J., Weinshilboum, R.M. Genomics (1999) [Pubmed]
  8. Catechol O-methyltransferase and indolethylamine N-methyltransferase activity in cerebrospinal fluid of dog, cat and human. Narasimhachari, N., Lin, R. Brain Res. (1975) [Pubmed]
  9. Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues. Kärkkäinen, J., Forsström, T., Tornaeus, J., Wähälä, K., Kiuru, P., Honkanen, A., Stenman, U.H., Turpeinen, U., Hesso, A. Scand. J. Clin. Lab. Invest. (2005) [Pubmed]
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