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Gene Review

CYP2U1  -  cytochrome P450, family 2, subfamily U,...

Homo sapiens

Synonyms: Cytochrome P450 2U1, P450TEC, SPG49, SPG56
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High impact information on CYP2U1


Biological context of CYP2U1

  • This process is demonstrated for four human pseudogenes from the cytochrome P450 family and one putatively functional P450 gene, CYP2U1, having a non-consensus intron boundary [3].

Anatomical context of CYP2U1

  • Based on the ability of CYP2U1 to generate bioactive eicosanoid derivatives, we postulate that CYP2U1 plays an important physiological role in fatty acid signaling processes in both cerebellum and thymus [1].

Associations of CYP2U1 with chemical compounds

  • Recombinant human CYP2U1 protein, expressed in baculovirus-infected Sf9 insect cells, was found to metabolize arachidonic acid exclusively to two region-specific products as determined by liquid chromatography-mass spectrometry [1].

Other interactions of CYP2U1

  • In the CYP2 family, only CYP2R1 and CYP2U1 are conserved as recognizable subfamilies across species [4].

Analytical, diagnostic and therapeutic context of CYP2U1

  • Western blot analysis revealed much higher CYP2U1 protein expression in rat brain than in thymus, particularly in limbic structures and in cortex [2].


  1. CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. Chuang, S.S., Helvig, C., Taimi, M., Ramshaw, H.A., Collop, A.H., Amad, M., White, J.A., Petkovich, M., Jones, G., Korczak, B. J. Biol. Chem. (2004) [Pubmed]
  2. Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1. Karlgren, M., Backlund, M., Johansson, I., Oscarson, M., Ingelman-Sundberg, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. 'Frankenstein genes', or the Mad Magazine version of the human pseudogenome. Nelson, D.R. Human genomics. (2004) [Pubmed]
  4. Comparison of P450s from human and fugu: 420 million years of vertebrate P450 evolution. Nelson, D.R. Arch. Biochem. Biophys. (2003) [Pubmed]
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