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Gene Review

CYP2R1  -  cytochrome P450, family 2, subfamily R,...

Homo sapiens

Synonyms: Cytochrome P450 2R1, Vitamin D 25-hydroxylase
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High impact information on CYP2R1


Biological context of CYP2R1


Anatomical context of CYP2R1


Associations of CYP2R1 with chemical compounds


Other interactions of CYP2R1

  • Thus, vitamin D metabolism by CYP2R1 was compared with human mitochondrial CYP27A1, which used to be considered a physiologically important vitamin D(3) 25-hydroxylase [9].
  • In the CYP2 family, only CYP2R1 and CYP2U1 are conserved as recognizable subfamilies across species [10].
  • Serum levels of 25(OH)D(3) and 1,25(OH)(2)D(3) were investigated in type 1 diabetes patients (n=173) and the mRNA expression of the CYP2R1, CYP27B1 and CYP24 genes in type 1 diabetes patients (n=33) and healthy controls (n=23) [11].
  • CYP3A4, a vitamin D-25-hydroxylase, and CYP1A1 had the highest 24-hydroxylase activity with 1 alpha-hydroxyvitamin D(2) (1 alpha OHD(2)) as substrate [12].


  1. Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Cheng, J.B., Levine, M.A., Bell, N.H., Mangelsdorf, D.J., Russell, D.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. Cheng, J.B., Motola, D.L., Mangelsdorf, D.J., Russell, D.W. J. Biol. Chem. (2003) [Pubmed]
  3. Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1. Karlgren, M., Backlund, M., Johansson, I., Oscarson, M., Ingelman-Sundberg, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  4. Effect of phototherapy on serum 25-hydroxyvitamin D in the Antarctic. Griffiths, A.P., Fairney, A. European journal of applied physiology and occupational physiology. (1989) [Pubmed]
  5. Dermal fibroblasts pretreated with a sterol Delta(7)-reductase inhibitor produce 25-hydroxyvitamin D(3) upon UVB irradiation. Vantieghem, K., De Haes, P., Bouillon, R., Segaert, S. J. Photochem. Photobiol. B, Biol. (2006) [Pubmed]
  6. CYP3A4 is a human microsomal vitamin D 25-hydroxylase. Gupta, R.P., Hollis, B.W., Patel, S.B., Patrick, K.S., Bell, N.H. J. Bone Miner. Res. (2004) [Pubmed]
  7. Novel extrahepatic cytochrome P450s. Karlgren, M., Miura, S., Ingelman-Sundberg, M. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  8. Analysis of the vitamin D system in basal cell carcinomas (BCCs). Mitschele, T., Diesel, B., Friedrich, M., Meineke, V., Maas, R.M., Gärtner, B.C., Kamradt, J., Meese, E., Tilgen, W., Reichrath, J. Lab. Invest. (2004) [Pubmed]
  9. Metabolism of vitamin D by human microsomal CYP2R1. Shinkyo, R., Sakaki, T., Kamakura, M., Ohta, M., Inouye, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  10. Comparison of P450s from human and fugu: 420 million years of vertebrate P450 evolution. Nelson, D.R. Arch. Biochem. Biophys. (2003) [Pubmed]
  11. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. Ramos-Lopez, E., Brück, P., Jansen, T., Pfeilschifter, J.M., Radeke, H.H., Badenhoop, K. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
  12. CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. Gupta, R.P., He, Y.A., Patrick, K.S., Halpert, J.R., Bell, N.H. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
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