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Gene Review

virC1  -  DNA-binding protein

Agrobacterium fabrum str. C58

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Disease relevance of virC1


High impact information on virC1


Biological context of virC1

  • Molecular characterization of the virC genes of the Ti plasmid [7].
  • Recent results from our laboratory have suggested that the virC operon which enhances T-DNA processing probably does so because the VirC1 protein interacts with overdrive (N. Toro, A. Datta, M. Yanofsky, and E. W. Nester, Proc. Natl. Acad. Sci. USA 85:8558-8562, 1988) [1].
  • The homology between virC genes of octopine- and nopaline-type Ti plasmids thus includes a conservation of genetic regulatory control mechanisms as well as considerable conservation of the primary structure of the protein products [7].

Associations of virC1 with chemical compounds

  • The virC (formerly bak) complementation group of the nopaline-type Ti plasmid pTiC58 encodes two proteins, VirC1 and VirC2 [7].

Regulatory relationships of virC1


Other interactions of virC1

  • Mutations in virC resulted in attenuated virulence on all hosts tested, the severity of attenuation varying markedly depending on the type of plant inoculated [7].


  1. The Agrobacterium tumefaciens virC1 gene product binds to overdrive, a T-DNA transfer enhancer. Toro, N., Datta, A., Carmi, O.A., Young, C., Prusti, R.K., Nester, E.W. J. Bacteriol. (1989) [Pubmed]
  2. DNA transfer from Agrobacterium to Zea mays or Brassica by agroinfection is dependent on bacterial virulence functions. Grimsley, N., Hohn, B., Ramos, C., Kado, C., Rogowsky, P. Mol. Gen. Genet. (1989) [Pubmed]
  3. Plant-inducible virulence promoter of the Agrobacterium tumefaciens Ti plasmid. Okker, R.J., Spaink, H., Hille, J., van Brussel, T.A., Lugtenberg, B., Schilperoort, R.A. Nature (1984) [Pubmed]
  4. Regulation of the virC and virD promoters of pTiC58 by the ros chromosomal mutation of Agrobacterium tumefaciens. Tait, R.C., Kado, C.I. Mol. Microbiol. (1988) [Pubmed]
  5. Identification of genes in the RosR regulon of Rhizobium etli. Bittinger, M.A., Handelsman, J. J. Bacteriol. (2000) [Pubmed]
  6. Factors affecting the rate of T-DNA transfer from Agrobacterium tumefaciens to Nicotiana glauca plant cells. Mozo, T., Hooykaas, P.J. Plant Mol. Biol. (1992) [Pubmed]
  7. Molecular characterization of the virC genes of the Ti plasmid. Close, T.J., Tait, R.C., Rempel, H.C., Hirooka, T., Kim, L., Kado, C.I. J. Bacteriol. (1987) [Pubmed]
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