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Gene Review

SLC26A9  -  solute carrier family 26 (anion exchanger)...

Homo sapiens

Synonyms: Anion transporter/exchanger protein 9, Solute carrier family 26 member 9
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Disease relevance of SLC26A9

  • Disease states that are associated with increased ammonia (NH3)/NH4+ generation (e.g., Helicobacter pylori) may impair gastric HCO3- secretion and therefore predispose patients to peptic ulcer by inhibiting SLC26A9 [1].

High impact information on SLC26A9


Anatomical context of SLC26A9


Associations of SLC26A9 with chemical compounds

  • Unlike other anion exchangers or transport proteins reported to date, SLC26A9 activity is inhibited by ammonium (NH4+) [1].

Analytical, diagnostic and therapeutic context of SLC26A9

  • Mucus thickness was measured with micropipettes, juxtamucosal pH (pH(jm)) was measured with pH-sensitive microelectrodes, blood flow was measured with laser-Doppler flowmetry, and mRNA levels of the bicarbonate transporter SLC26A9 were quantified with real-time PCR [3].


  1. SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Xu, J., Henriksnäs, J., Barone, S., Witte, D., Shull, G.E., Forte, J.G., Holm, L., Soleimani, M. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  2. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. Lohi, H., Kujala, M., Makela, S., Lehtonen, E., Kestila, M., Saarialho-Kere, U., Markovich, D., Kere, J. J. Biol. Chem. (2002) [Pubmed]
  3. Impaired mucus-bicarbonate barrier in Helicobacter pylori-infected mice. Henriksnäs, J., Phillipson, M., Storm, M., Engstrand, L., Soleimani, M., Holm, L. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
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