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Gene Review

SLC26A8  -  solute carrier family 26 (anion exchanger)...

Homo sapiens

Synonyms: Anion exchange transporter, SPGF3, Solute carrier family 26 member 8, TAT1, Testis anion transporter 1
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Disease relevance of SLC26A8


High impact information on SLC26A8


Biological context of SLC26A8

  • The presence of HIV-1 and HIV-2 trans-activator proteins, tat1 and tat2, respectively, greatly increases viral gene expression from their homologous LTRs [9].
  • Using a cervical carcinoma cell line (SiHa), E2 enhancement of URR-directed gene expression was elevated in the presence of extracellular tat1 or during cocultivation with HIV-1-infected cells [10].

Anatomical context of SLC26A8


Associations of SLC26A8 with chemical compounds


Other interactions of SLC26A8


Analytical, diagnostic and therapeutic context of SLC26A8

  • TAT mRNA was demonstrated in tissue sections and identified as TAT-1 and -2 by RT-PCR and DNA-sequencing [4].


  1. Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure. Mäkelä, S., Eklund, R., Lähdetie, J., Mikkola, M., Hovatta, O., Kere, J. Mol. Hum. Reprod. (2005) [Pubmed]
  2. A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. Derijk, R.H., W??st, S., Meijer, O.C., Zennaro, M.C., Federenko, I.S., Hellhammer, D.H., Giacchetti, G., Vreugdenhil, E., Zitman, F.G., de Kloet, E.R. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  3. Human immunodeficiency virus type 1 reverse transcription is stimulated by tat from other lentiviruses. Hooker, C.W., Scott, J., Apolloni, A., Parry, E., Harrich, D. Virology (2002) [Pubmed]
  4. Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancer. Bjartell, A., Paju, A., Zhang, W.M., Gadaleanu, V., Hansson, J., Landberg, G., Stenman, U.H. Prostate (2005) [Pubmed]
  5. Activity of human immunodeficiency virus type 1 promoter/TAR regions and tat1 genes derived from individuals with different rates of disease progression. Kirchhoff, F., Greenough, T.C., Hamacher, M., Sullivan, J.L., Desrosiers, R.C. Virology (1997) [Pubmed]
  6. Cyst fluid of ovarian cancer patients contains high concentrations of trypsinogen-2. Koivunen, E., Itkonen, O., Halila, H., Stenman, U.H. Cancer Res. (1990) [Pubmed]
  7. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. Lohi, H., Kujala, M., Makela, S., Lehtonen, E., Kestila, M., Saarialho-Kere, U., Markovich, D., Kere, J. J. Biol. Chem. (2002) [Pubmed]
  8. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. Toure, A., Morin, L., Pineau, C., Becq, F., Dorseuil, O., Gacon, G. J. Biol. Chem. (2001) [Pubmed]
  9. Human chromosome-dependent and -independent pathways for HIV-2 trans-activation. Hart, C.E., Westhafer, M.A., Galphin, J.C., Ou, C.Y., Bacheler, L.T., Petteway, S.R., Wasmuth, J.J., Chen, I.S., Schochetman, G. AIDS Res. Hum. Retroviruses (1991) [Pubmed]
  10. The HIV-1 tat protein enhances E2-dependent human papillomavirus 16 transcription. Vernon, S.D., Hart, C.E., Reeves, W.C., Icenogle, J.P. Virus Res. (1993) [Pubmed]
  11. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. Park, S.Y., Kim, J.K., Kim, I.J., Choi, B.K., Jung, K.Y., Lee, S., Park, K.J., Chairoungdua, A., Kanai, Y., Endou, H., Kim, d.o. .K. Arch. Pharm. Res. (2005) [Pubmed]
  12. Human ovarian tumor-associated trypsin. Its purification and characterization from mucinous cyst fluid and identification as an activator of pro-urokinase. Koivunen, E., Huhtala, M.L., Stenman, U.H. J. Biol. Chem. (1989) [Pubmed]
  13. Purification and characterization of tyrosine aminotransferase activities from Anchusa officinalis cell cultures. De-Eknamkul, W., Ellis, B.E. Arch. Biochem. Biophys. (1987) [Pubmed]
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