Disease relevance of Admr

• L-Asparaginase from Cylindrocarpon obtusisporum MB-10 inhibits the growth of Ascites Fibrosarcoma and Dalton's Lymphoma tumor cells in vivo and significantly increases the survival rate of tumor bearing mice [1].

High impact information on Admr

• 5. The mRNA levels encoding CRLR receptor declined with culture duration, whereas those encoding L1/G10D receptor remained stable [2].
• We have investigated the involvement of AM and its receptor (AM-R) in developing mouse mammary glands and have examined what influence ovarian hormones have on AM and AM-R expression in this system [3].
• Tissues from ductal morphogenesis, virgin adult, pregnancy, and lactation stages were assessed for AM and AM-R by molecular, biochemical and immunohistochemical techniques [3].
• Results from these studies indicated that messenger RNA for AM and AM-R and immunoreactivity for AM were expressed in the luminal epithelium of small and large ducts and in terminal end buds [3].
• The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction [4].

Biological context of Admr

• Instead, RCP represents a novel class of protein required to couple the adrenomedullin receptor to the cellular signal transduction pathway [4].

Anatomical context of Admr

• Antitumor activity of L-asparaginase from Cylindrocarpon obtusisporum MB-10 and its effect on the immune system [1].

Other interactions of Admr

• RCP co-immunoprecipitated with CRLR and RAMP2, indicating that a functional adrenomedullin receptor is composed of at least three proteins: the ligand binding protein (CRLR), an accessory protein (RAMP2), and a coupling protein for signal transduction (RCP) [4].

References