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Gene Review

GPR182  -  G protein-coupled receptor 182

Homo sapiens

Synonyms: 7TMR, ADMR, AM-R, AMR, G-protein coupled receptor 182, ...
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Disease relevance of ADMR


Psychiatry related information on ADMR


High impact information on ADMR


Chemical compound and disease context of ADMR


Biological context of ADMR

  • Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR [1].
  • Since Ishikawa cells express the putative ADM-receptor CRLR-RAMP2 the production and secretion of ADM with the consecutive upregulation of Bcl-2 could establish an autocrine/paracrine mechanism rescuing malignant cells from hypoxic cell death [11].
  • The CGRP1-receptor antagonists BIBN4096BS and CGRP-(8-37) and the adrenomedullin receptor antagonist adrenomedullin-(22-52) significantly inhibited the effect of adrenomedullin (n=7, P<0.05 for both arteries) on dural and pial artery diameter and mean arterial blood pressure [12].
  • Transfection studies performed with the putative hAMR yield similar results [13].
  • The present findings suggest that the AM/AM-R regulatory system plays a major role in respiratory physiology and lung carcinogenesis and that new functions for AM remain to be identified [14].

Anatomical context of ADMR


Associations of ADMR with chemical compounds

  • METHODS: A human bladder cancer cell line resistant to doxorubicin, BIU-87/ADMR, has been established in vitro by exposing BIU-87 parent cells to progressively increasing concentrations of the drug over a period of 8 months [20].
  • We conclude that ADM increases intracellular cGMP levels in SV-CISM-2 cells through activation of the ADM receptor and subsequent stimulation of a Gi-mediated membrane-bound guanylate cyclase [21].
  • Since glucocorticoid responsive elements were recently identified in the human CRLR promoter and that glucocorticoids exert a major action in bones, we investigated the acute effect of dexamethasone (Dex) treatment on ADM receptor components in osteoblastic cell types: the MC3T3-E1 cells and calvaria-derived osteoblastic cells [22].
  • METHODS: We examined the effect of locally injected dihydrotestosterone (DHT) and ADM, and the co-administration of DHT with an ADM receptor antagonist (ADM 22-52) on prostatic blood flow [23].
  • Thus, estrogen can signal by the same mechanism as various other hormones, through a specific 7TM receptor [24].

Other interactions of ADMR

  • All the effect of ADM were reversed by the ADM-receptor antagonist ADM(22-52) [25].
  • CRLR may function as a calcitonin gene-related peptide or a selective ADM receptor depending on the expression of the subtype 1 or the subtypes 2 and 3 of a family of proteins, named receptor-activity-modifying protein (RAMPs) [25].
  • The results reveal competition between the different RAMPs in the regulation of CGRP/ADM receptor activity [26].
  • Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1 [27].
  • Receptor-activity-modifying protein (RAMP) 2 and RAMP3, ADM receptor subunits, are expressed in autonomic centers including the PVN and supraoptic nucleus [28].

Analytical, diagnostic and therapeutic context of ADMR


  1. Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR. Ramachandran, V., Arumugam, T., Hwang, R.F., Greenson, J.K., Simeone, D.M., Logsdon, C.D. Cancer Res. (2007) [Pubmed]
  2. Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells. Xu, Q., Ohara, N., Chen, W., Liu, J., Sasaki, H., Morikawa, A., Sitruk-Ware, R., Johansson, E.D., Maruo, T. Hum. Reprod. (2006) [Pubmed]
  3. Adrenomedullin enhances invasion by trophoblast cell lines. Zhang, X., Green, K.E., Yallampalli, C., Dong, Y.L. Biol. Reprod. (2005) [Pubmed]
  4. Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Ono, Y., Okano, I., Kojima, M., Okada, K., Kangawa, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  5. Human calcitonin receptor-like receptor for adrenomedullin: genomic structure, eight single-nucleotide polymorphisms, and haplotype analysis. Nakazawa, I., Nakajima, T., Harada, H., Ishigami, T., Umemura, S., Emi, M. J. Hum. Genet. (2001) [Pubmed]
  6. Effect of the pattern of food intake on human energy metabolism. Verboeket-van de Venne, W.P., Westerterp, K.R., Kester, A.D. Br. J. Nutr. (1993) [Pubmed]
  7. Adrenomedullin, a multifunctional regulatory peptide. Hinson, J.P., Kapas, S., Smith, D.M. Endocr. Rev. (2000) [Pubmed]
  8. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Poyner, D.R., Sexton, P.M., Marshall, I., Smith, D.M., Quirion, R., Born, W., Muff, R., Fischer, J.A., Foord, S.M. Pharmacol. Rev. (2002) [Pubmed]
  9. Molecular Pharmacological Phenotyping of EBI2: AN ORPHAN SEVEN-TRANSMEMBRANE RECEPTOR WITH CONSTITUTIVE ACTIVITY. Rosenkilde, M.M., Benned-Jensen, T., Andersen, H., Holst, P.J., Kledal, T.N., Lüttichau, H.R., Larsen, J.K., Christensen, J.P., Schwartz, T.W. J. Biol. Chem. (2006) [Pubmed]
  10. Detection of the 170 kDa P-glycoprotein in neoplastic and normal tissues. Ronchi, E., Sanfilippo, O., Di Fronzo, G., Bani, M.R., Della Torre, G., Catania, S., Silvestrini, R. Tumori. (1989) [Pubmed]
  11. Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. Oehler, M.K., Norbury, C., Hague, S., Rees, M.C., Bicknell, R. Oncogene (2001) [Pubmed]
  12. The in vivo effect of adrenomedullin on rat dural and pial arteries. Juhl, L., Petersen, K.A., Larsen, E.H., Jansen-Olesen, I., Olesen, J. Eur. J. Pharmacol. (2006) [Pubmed]
  13. Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response. Kennedy, S.P., Sun, D., Oleynek, J.J., Hoth, C.F., Kong, J., Hill, R.J. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  14. Adrenomedullin receptor expression in human lung and in pulmonary tumors. Martínez, A., Miller, M.J., Catt, K.J., Cuttitta, F. J. Histochem. Cytochem. (1997) [Pubmed]
  15. Expression and role of adrenomedullin and its receptor in patients with chronic obstructive pulmonary disease. Xu, P., Dai, A., Zhou, H., Shen, H., Liu, L., Song, W. Chin. Med. J. (2003) [Pubmed]
  16. A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1. Bühlmann, N., Leuthäuser, K., Muff, R., Fischer, J.A., Born, W. Endocrinology (1999) [Pubmed]
  17. The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. Kamitani, S., Asakawa, M., Shimekake, Y., Kuwasako, K., Nakahara, K., Sakata, T. FEBS Lett. (1999) [Pubmed]
  18. Autocrine role of adrenomedullin in the human adrenal cortex. Thomson, L.M., Kapas, S., Carroll, M., Hinson, J.P. J. Endocrinol. (2001) [Pubmed]
  19. Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. Hänze, J., Dittrich, K., Dötsch, J., Rascher, W. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  20. Establishment of doxorubicin-resistant human bladder cancer cell line (BUI-87/ADMR) and its mechanism of multidrug resistance. Guo, H., Lu, G., Xiong, X., Dong, J., Liu, S. Chin. Med. J. (1997) [Pubmed]
  21. Activation of particulate guanylate cyclase by adrenomedullin in cultured SV-40 transformed cat iris sphincter smooth muscle (SV-CISM-2) cells. Ali, N., Yousufzai, S.Y., Abdel-Latif, A.A. Cell. Signal. (2000) [Pubmed]
  22. RAMPs and CRLR expressions in osteoblastic cells after dexamethasone treatment. Uzan, B., de Vernejoul, M.C., Cressent, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  23. Participation of adrenomedullin and its relation with vascular endothelial growth factor in androgen regulation of prostatic blood flow in vivo. Shibata, Y., Kashiwagi, B., Arai, S., Magari, T., Suzuki, K., Honma, S. Urology (2006) [Pubmed]
  24. GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Filardo, E.J., Thomas, P. Trends Endocrinol. Metab. (2005) [Pubmed]
  25. Adrenomedullin and its receptors are expressed in the zona glomerulosa of human adrenal gland: evidence that ADM enhances proliferation and decreases apoptosis in cultured ZG cells. Rebuffat, P., Forneris, M.L., Aragona, F., Ziolkowska, A., Malendowicz, L.K., Nussdorfer, G.G. Int. J. Mol. Med. (2002) [Pubmed]
  26. Receptor activity modifying proteins regulate the activity of a calcitonin gene-related peptide receptor in rabbit aortic endothelial cells. Muff, R., Leuthäuser, K., Bühlmann, N., Foord, S.M., Fischer, J.A., Born, W. FEBS Lett. (1998) [Pubmed]
  27. Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1. Bomberger, J.M., Spielman, W.S., Hall, C.S., Weinman, E.J., Parameswaran, N. J. Biol. Chem. (2005) [Pubmed]
  28. Autonomic and neuroendocrine actions of adrenomedullin in the brain: mechanisms for homeostasis. Shan, J., Stachniak, T., Jhamandas, J.H., Krukoff, T.L. Regul. Pept. (2003) [Pubmed]
  29. High-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures. Inoue, S., Kawaguchi, M., Sakamoto, T., Kitaguchi, K., Furuya, H., Sakaki, T. Anesthesiology (2002) [Pubmed]
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