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Gene Review

Fgf4  -  fibroblast growth factor 4

Rattus norvegicus

Synonyms: Hst, Hst1
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Disease relevance of Fgf4


High impact information on Fgf4

  • Laser-captured microdissection (LCM) coupled with RT-PCR analysis revealed that expression of Hst-1/Fgf-4 was found in epithelial cell of the villi and crypt cells [3].
  • OBJECTIVES: We investigated the potentiation of gene therapy using fibroblast growth factor 4 (FGF4)-gene by combining plasmid deoxyribonucleic acid (DNA) with biodegradable gelatin hydrogel (GHG) [1].
  • Synchrotron radiation microangiography (spatial resolution, 20 microm) and flow determination with microspheres confirmed significant vascular responsiveness to adenosine administration in the GHG-FGF4 group, but not in the naked FGF4-gene and the control [1].
  • CONCLUSIONS: The GHG-FGF4 complex promoted angiogenesis and blood flow regulation of the newly developed vessels possibly by extending gene degradation and improving transfection efficiency without the biohazard associated with viral vectors [1].
  • Rat Fgf3 and Fgf4 genes, consisting of three exons, were clustered in tail-to-head manner with an interval of about 16 kb [4].

Anatomical context of Fgf4


Analytical, diagnostic and therapeutic context of Fgf4

  • Four weeks after gene transfer, hindlimb muscle necrosis was ameliorated more markedly in the GHG-FGF4 group than in the naked FGF4-gene and GHG-beta-galactosidase (control) groups (p < 0.05, Kruskal-Wallis test) [1].
  • Rats were fed on a low-starch, high-fat diet (Lst; starch 5 and fat 73% of gross energy), or a high-starch, low-fat diet (Hst; starch 70 and fat 7% of gross energy) [6].


  1. Biodegradable gelatin hydrogel potentiates the angiogenic effect of fibroblast growth factor 4 plasmid in rabbit hindlimb ischemia. Kasahara, H., Tanaka, E., Fukuyama, N., Sato, E., Sakamoto, H., Tabata, Y., Ando, K., Iseki, H., Shinozaki, Y., Kimura, K., Kuwabara, E., Koide, S., Nakazawa, H., Mori, H. J. Am. Coll. Cardiol. (2003) [Pubmed]
  2. Bridge grafts of fibroblast growth factor-4-secreting schwannoma cells promote functional axonal regeneration in the nigrostriatal pathway of the adult rat. Brecknell, J.E., Du, J.S., Muir, E., Fidler, P.S., Hlavin, M.L., Dunnett, S.B., Fawcett, J.W. Neuroscience (1996) [Pubmed]
  3. HST-1/FGF-4 plays a critical role in crypt cell survival and facilitates epithelial cell restitution and proliferation. Sasaki, H., Hirai, K., Yamamoto, H., Tanooka, H., Sakamoto, H., Iwamoto, T., Takahashi, T., Terada, M., Ochiya, T. Oncogene (2004) [Pubmed]
  4. Comparative genomics on mammalian Fgf3-Fgf4 locus. Katoh, M., Katoh, M. Int. J. Oncol. (2005) [Pubmed]
  5. Rat bone marrow mesenchymal stem cells differentiate into hepatocytes in vitro. Kang, X.Q., Zang, W.J., Song, T.S., Xu, X.L., Yu, X.J., Li, D.L., Meng, K.W., Wu, S.L., Zhao, Z.Y. World J. Gastroenterol. (2005) [Pubmed]
  6. Dietary-induced increases of disaccharidase activities in rat jejunum. Samulitis-dos Santos, B.K., Goda, T., Koldovskỳ, O. Br. J. Nutr. (1992) [Pubmed]
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