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Gene Review

FGF4  -  fibroblast growth factor 4

Bos taurus

Synonyms: HBGF-4, HST
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Disease relevance of FGF4


High impact information on FGF4

  • The main finding was that endogenous PRL and GH maintained progesterone secretion in HST heifers in a similar manner to that in SOC throughout pregnancy [2].
  • The second finding was that parturition and lactation occurred in HST heifers with calf delivery induced to occur at the same time as SOC [2].
  • Milk production in HST animals was severely limited, and postpartum estrus obliterated compared with SOC [2].
  • Although HST reduced PRL secretion, it did not abolish the effect of seasonal changes (P < 0.01); circulating PRL concentration increased six-fold by shifts in photoperiod and temperature from winter to summer in these stalk-transected calves [3].
  • Heparan sulfate proteoglycan increases inner cell mass numbers and this may be due to interactions with the growth factors fibroblast growth factor 4 (FGF-4) and granulocyte-macrophage colony-stimulating factor [4].

Other interactions of FGF4

  • PRL remained low in both HST and SOC groups for three months after surgery [3].

Analytical, diagnostic and therapeutic context of FGF4

  • Using RT-PCR techniques we have previously detected the aberrant expression of FGF4, FGFr2 and IL6 in a significant proportion of bovine granulosa cell-derived nuclear transfer embryos, which correlated with a limited developmental potential in vivo [5].


  1. An unexpected transforming gene in calf-thymus carrier DNA: bovine hst. Yu, J.C., DeSeabra, A.J., Wang, L.M., Fleming, T.P., Chedid, M., Miki, T., Heidaran, M.A. Gene (1995) [Pubmed]
  2. Pregnancy, parturition, and lactation in hypophyseal stalk-transected beef heifers. Anderson, L.L., Hard, D.L., Carpenter, L.S., Awotwi, E.K., Diekman, M.A., Trenkle, A.H., Cho, J. J. Endocrinol. (1999) [Pubmed]
  3. Seasonal regulation of prolactin secretion in hypophyseal stalk transected beef calves. Cho, S.J., Hard, D.L., Carpenter, L.S., Diekman, M.A., Anderson, L.L. Anim. Reprod. Sci. (1998) [Pubmed]
  4. The effect of extracellular matrix molecules on mouse preimplantation embryo development in vitro. Figueiredo, F., Jones, G.M., Thouas, G.A., Trounson, A.O. Reprod. Fertil. Dev. (2002) [Pubmed]
  5. Comparison of gene transcription in cloned bovine embryos produced by different nuclear transfer techniques. Daniels, R., Hall, V.J., French, A.J., Korfiatis, N.A., Trounson, A.O. Mol. Reprod. Dev. (2001) [Pubmed]
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