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Gene Review: 

Nr0b2  -  nuclear receptor subfamily 0, group B,...

Rattus norvegicus

Synonyms: Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Shp, Small heterodimer partner
 
 
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Disease relevance of Nr0b2

 

High impact information on Nr0b2

  • Using these cell lines, we demonstrated that SHP binds JunD and inhibits DNA binding of adaptor protein (AP)-1 induced by thrombin [1].
  • Exposure of HSCs to FXR ligands caused a 3-fold increase of SHP, reduced alpha1(I)collagen and TGF-beta1 by approximately 60%-70% and abrogates alpha1(I) collagen mRNA up-regulation induced by thrombin and TGF-beta1 [1].
  • BACKGROUND AND AIMS: The farnesoid X receptor (FXR) is an endogenous sensor for bile acids and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene expression [1].
  • In addition, bile acid biosynthesis was inhibited despite the reduced expression of the small heterodimer partner (SHP) and activated LXRalpha, which also appeared to contribute to the accumulation of oxysterols followed by the acceleration of cholesterol efflux [3].
  • SHP is rapidly induced within 2 h following treatment of mice with ethynylestradiol (EE) or the estrogen receptor alpha (ERalpha)-selective compound propyl pyrazole triol (PPT) [4].
 

Biological context of Nr0b2

  • In conclusion, procyanidins improve the atherosclerotic risk index in the postprandial state, inducing in the liver the overexpression of CYP7A1 (suggesting an increase of cholesterol elimination via bile acids) and SHP, a nuclear receptor emerging as a key regulator of lipid homeostasis at the transcriptional level [5].
 

Physical interactions of Nr0b2

  • It has been recently reported that bile acid-activated farnesoid X receptor (FXR) induces the small heterodimer partner (SHP) that interacts with alpha-fetoprotein transcription factor (FTF) and down-regulates CYP7A1 transcription [6].

References

  1. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pellicciari, R., Morelli, A. Gastroenterology (2004) [Pubmed]
  2. Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner. Park, K.G., Lee, K.M., Seo, H.Y., Suh, J.H., Kim, H.S., Wang, L., Won, K.C., Lee, H.W., Park, J.Y., Lee, K.U., Kim, J.G., Kim, B.W., Choi, H.S., Lee, I.K. Diabetes (2007) [Pubmed]
  3. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hirayama, T., Honda, A., Matsuzaki, Y., Miyazaki, T., Ikegami, T., Doy, M., Xu, G., Lea, M., Salen, G. Hepatology (2006) [Pubmed]
  4. Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner. Lai, K., Harnish, D.C., Evans, M.J. J. Biol. Chem. (2003) [Pubmed]
  5. Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. Del Bas, J.M., Fernández-Larrea, J., Blay, M., Ardèvol, A., Salvadó, M.J., Arola, L., Bladé, C. FASEB J. (2005) [Pubmed]
  6. On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha. Yang, Y., Zhang, M., Eggertsen, G., Chiang, J.Y. Biochim. Biophys. Acta (2002) [Pubmed]
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