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Gene Review

P8  -  nuclear proten 1

Rattus norvegicus

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Disease relevance of Nupr1


Psychiatry related information on Nupr1

  • The effect of exposure to the magnetic and radio-frequency fields associated with Nuclear Magnetic Resonance Imaging (MRI) on two standard animal behavior tests, was examined in rats [6].

High impact information on Nupr1


Chemical compound and disease context of Nupr1


Biological context of Nupr1

  • Exposure to serum-free medium (i) sensitized astrocytes to oxidative stress, (ii) reduced the expression of several genes involved in protection against oxidative stress, including heme oxygenase 1, and (iii) changed the expression of several genes involved in the control of cell survival, including the stress-regulated protein p8 [15].
  • As a model, we used phosphodiester dumbbell oligonucleotides containing a binding site for the liver-enriched transcription factor HNF-1 (Hepatocyte Nuclear Factor 1) [16].
  • BACKGROUND/AIMS: Nuclear translocation and DNA binding of NF-kappaB is essential, as interleukin-1beta (IL-1beta) stimulates the induction of inducible nitric oxide synthase (iNOS) gene expression in hepatocytes [17].
  • METHODS: Nuclear magnetic resonance techniques were used in an isolated, perfused rat heart model of acute hibernation to determine the changes in metabolites and creatine kinase kinetics [18].
  • Dissociation kinetics verified the necessity of an extended incubation (86 h) for maximum exchange at 4 degrees C. Nuclear androgen receptor concentration per mg DNA decreased between 15 and 25 days of age, from 375 to 146 fmol per mg DNA, then increased to 584 fmol per mg DNA at 90 days [19].

Anatomical context of Nupr1


Associations of Nupr1 with chemical compounds

  • METHODS: Nuclear extracts were prepared from rat HSCs isolated and cultured from normal and carbon tetrachloride injured rat livers and from HSCs isolated from human liver [25].
  • Effect of allylisopropylacetamide on Nuclear Ribonucleic Acid synthesis in rat liver [26].
  • 3. Nuclear uracil-DNA glycosylase catalyzes the release of free uracil from both single-stranded and double-stranded DNA with the former being the preferred substrate [27].
  • 3. Nuclear preparations resemble activated rather than native microsomal preparations in failing to transfer glucuronic acid from 4-nitrophenyl glucuronide to 2-aminophenol [23].
  • We warn Nuclear Medicine scientists against the use of colloid uptake measurement as a marker of the bone macrophagic population, especially in situations associated with modified bone plasma flow [28].

Regulatory relationships of Nupr1


Other interactions of Nupr1

  • AIM: Nuclear factor kappa B (NF-kappaB) regulates a large number of genes involved in the inflammatory response to critical illnesses, but it is not known if and how NF-kappaB is activated and intercellular adhesion molecule-1 (ICAM-1) expressed in the gut following traumatic brain injury (TBI) [31].
  • The level of Nuclear Factor (kappa) inhibitor (IkappaBalpha) in liver was decreased and DNA-binding activity of Nuclear Factor-kappaB (NF-kappaB) was increased after thermal injury. p38 MAP kinase was more significantly activated in liver harvested from burn rats than from shams [32].
  • RESULTS: Nuclear extract isolated from obstructed bladders showed intense activator protein-1 binding activity 3, 6 and 24 hours after obstruction as well as increased nuclear factor-kappaB binding activity after 6 and 24 hours [33].
  • Heat stressing stimulates nuclear protein kinase C raising diacylglycerol levels. Nuclear protein kinase C activation precedes Hsp70 mRNA expression [34].

Analytical, diagnostic and therapeutic context of Nupr1

  • METHODS: Nuclear protein bound to the lactase gene cis element, CE-LPH1, was analyzed by electrophoretic mobility shift assays and supershifts with Cdx2 antibody [35].
  • In vivo assessment of liver mass in the rat was achieved using several parameters obtained by scintigraphy, including one computed using a Nuclear Data 50:50 analysis system [36].
  • RESULTS: Nuclear factor kappaB-DNA binding activity was significantly increased at the end of reperfusion in rat myocardium, and cytosolic IkappaB-alpha was decreased [37].
  • The ultrastructure of the accessory sex organs of the male rat. XI. Nuclear alterations of prostatic epithelial cells induced by castration [38].
  • We described the use of Nuclear microscopy (microbeam PIXE) for the quantitative micron scale analysis of platinum based chemotherapeutic agents in individual cell and tissue slices [39].


  1. Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner. Park, K.G., Lee, K.M., Seo, H.Y., Suh, J.H., Kim, H.S., Wang, L., Won, K.C., Lee, H.W., Park, J.Y., Lee, K.U., Kim, J.G., Kim, B.W., Choi, H.S., Lee, I.K. Diabetes (2007) [Pubmed]
  2. Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice. Nakamura, Y., Fukiage, C., Shih, M., Ma, H., David, L.L., Azuma, M., Shearer, T.R. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  3. Temporal profile of CRE DNA-binding activity in the rat hippocampus following a kindling stimulation. Kashihara, K., Sato, K., Akiyama, K., Ishihara, T., Hayabara, T., Abe, K. Epilepsy Res. (2000) [Pubmed]
  4. Effect of ethanol on hepatic energy metabolism and intracellular pH in chronically ethanol-treated rats. A 31P NMR study of normoxic or hypoxic perfused liver. Desmoulin, F., Canioni, P., Masson, S., Gérolami, A., Cozzone, P.J. NMR in biomedicine. (1990) [Pubmed]
  5. Limitations of nls beta-galactosidase as a marker for studying myogenic lineage or the efficacy of myoblast transfer. Yang, J., Ontell, M.P., Kelly, R., Watkins, S.C., Ontell, M. Anat. Rec. (1997) [Pubmed]
  6. Behavioral effects of exposure to nuclear magnetic resonance imaging: I. Open-field behavior and passive avoidance learning in rats. Ossenkopp, K.P., Innis, N.K., Prato, F.S., Sestini, E. Magnetic resonance imaging. (1986) [Pubmed]
  7. Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Bortell, R., Owen, T.A., Bidwell, J.P., Gavazzo, P., Breen, E., van Wijnen, A.J., DeLuca, H.F., Stein, J.L., Lian, J.B., Stein, G.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Ca2+- and Protein Kinase C-dependent Signaling Pathway for Nuclear Factor-{kappa}B Activation, Inducible Nitric-oxide Synthase Expression, and Tumor Necrosis Factor-{alpha} Production in Lipopolysaccharide-stimulated Rat Peritoneal Macrophages. Zhou, X., Yang, W., Li, J. J. Biol. Chem. (2006) [Pubmed]
  9. Induction of Neutrophil Gelatinase-Associated Lipocalin in Vascular Injury via Activation of Nuclear Factor-{kappa}B. Bu, D.X., Hemdahl, A.L., Gabrielsen, A., Fuxe, J., Zhu, C., Eriksson, P., Yan, Z.Q. Am. J. Pathol. (2006) [Pubmed]
  10. Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-{kappa}B Pathway in Rat Liver. Boden, G., She, P., Mozzoli, M., Cheung, P., Gumireddy, K., Reddy, P., Xiang, X., Luo, Z., Ruderman, N. Diabetes (2005) [Pubmed]
  11. Nuclear protein p8 is associated with glucose-induced pancreatic beta-cell growth. Päth, G., Opel, A., Knoll, A., Seufert, J. Diabetes (2004) [Pubmed]
  12. The Expression of Nuclear Factor kappa B in Inflammation-Induced Rat Corneal Neovascularization. Zhang, M.C., Wang, Y., Yang, Y. Ocul. Immunol. Inflamm. (2006) [Pubmed]
  13. Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells. Tokunou, T., Shibata, R., Kai, H., Ichiki, T., Morisaki, T., Fukuyama, K., Ono, H., Iino, N., Masuda, S., Shimokawa, H., Egashira, K., Imaizumi, T., Takeshita, A. Circulation (2003) [Pubmed]
  14. Reversal Effect of Thalidomide on Established Hepatic Cirrhosis in Rats via Inhibition of Nuclear Factor-kappaB/Inhibitor of Nuclear Factor-kappaB Pathway. Lv, P., Luo, H.S., Zhou, X.P., Xiao, Y.J., Paul, S.C., Si, X.M., Zhou, Y.H. Arch. Med. Res. (2007) [Pubmed]
  15. p8 Upregulation sensitizes astrocytes to oxidative stress. Carracedo, A., Egia, A., Guzmán, M., Velasco, G. FEBS Lett. (2006) [Pubmed]
  16. Ex vivo regulation of specific gene expression by nanomolar concentration of double-stranded dumbbell oligonucleotides. Clusel, C., Ugarte, E., Enjolras, N., Vasseur, M., Blumenfeld, M. Nucleic Acids Res. (1993) [Pubmed]
  17. Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes. Teshima, S., Nakanishi, H., Nishizawa, M., Kitagawa, K., Kaibori, M., Yamada, M., Habara, K., Kwon, A.H., Kamiyama, Y., Ito, S., Okumura, T. J. Hepatol. (2004) [Pubmed]
  18. Myocardial adaptation during acute hibernation: mechanisms of phosphocreatine recovery. Schaefer, S., Carr, L.J., Kreutzer, U., Jue, T. Cardiovasc. Res. (1993) [Pubmed]
  19. Increase in testicular androgen receptor during sexual maturation in the rat. Buzek, S.W., Sanborn, B.M. Biol. Reprod. (1988) [Pubmed]
  20. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Garcia, J.H., Yoshida, Y., Chen, H., Li, Y., Zhang, Z.G., Lian, J., Chen, S., Chopp, M. Am. J. Pathol. (1993) [Pubmed]
  21. Unoccupied 1,25-dihydroxyvitamin D3 receptors. Nuclear/cytosol ratio depends on ionic strength. Walters, M.R., Hunziker, W., Norman, A.W. J. Biol. Chem. (1980) [Pubmed]
  22. Quantitative cytological analysis of functional changes in adrenomedullary chromaffin cells in normal, sham-operated, and pinealectomized rats in relation to time of day: III. Nuclear density. Kachi, T., Banerji, T.K., Quay, W.B. J. Pineal Res. (1988) [Pubmed]
  23. Evidence from rat liver nuclear preparations that latency of microsomal UDP-glucuronosyltransferase is associated with vesiculation. Wishart, G.J., Fry, D.J. Biochem. J. (1980) [Pubmed]
  24. Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity. Toliver-Kinsky, T., Papaconstantinou, J., Perez-Polo, J.R. J. Neurosci. Res. (1997) [Pubmed]
  25. Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells. Vincent, K.J., Jones, E., Arthur, M.J., Smart, D.E., Trim, J., Wright, M.C., Mann, D.A. Gut (2001) [Pubmed]
  26. Effect of allylisopropylacetamide on Nuclear Ribonucleic Acid synthesis in rat liver. Sardana, M.K., Satyanarayana Rao, M.R., Padmanaban, G. Biochem. J. (1975) [Pubmed]
  27. Purification of nuclear and mitochondrial uracil-DNA glycosylase from rat liver. Identification of two distinct subcellular forms. Domena, J.D., Mosbaugh, D.W. Biochemistry (1985) [Pubmed]
  28. Uptake of colloids by bone is dependent on bone blood flow. Schuind, F., Schoutens, A., Verhas, M., Verschaeren, A. European journal of nuclear medicine. (1984) [Pubmed]
  29. Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas. Jiang, P.H., Motoo, Y., Iovanna, J.L., Pébusque, M.J., Xie, M.J., Okada, G., Sawabu, N. JOP (2004) [Pubmed]
  30. Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro. Widera, D., Mikenberg, I., Kaus, A., Kaltschmidt, C., Kaltschmidt, B. European cells & materials [electronic resource]. (2006) [Pubmed]
  31. Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in rats. Hang, C.H., Shi, J.X., Li, J.S., Li, W.Q., Yin, H.X. World J. Gastroenterol. (2005) [Pubmed]
  32. p38 mitogen-activated protein kinase inhibition attenuates burn-induced liver injury in rats. Chen, X.L., Xia, Z.F., Yu, Y.X., Wei, D., Wang, C.R., Ben, D.F. Burns : journal of the International Society for Burn Injuries. (2005) [Pubmed]
  33. Activation of the transcription factors nuclear factor-kappaB and activator protein-1 in bladder smooth muscle exposed to outlet obstruction and mechanical stretching. Persson, K., Dean-Mckinney, T., Steers, W.D., Tuttle, J.B. J. Urol. (2001) [Pubmed]
  34. Heat stressing stimulates nuclear protein kinase C raising diacylglycerol levels. Nuclear protein kinase C activation precedes Hsp70 mRNA expression. Ritz, M.F., Masmoudi, A., Matter, N., Rogue, P., Lang, D., Freysz, L., Malviya, A.N. Receptor (1993) [Pubmed]
  35. The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. Fang, R., Santiago, N.A., Olds, L.C., Sibley, E. Gastroenterology (2000) [Pubmed]
  36. In vivo assessment of liver size in the rat. Leach, K.G., Karran, S.J., Wisbey, M.L., Blumgart, L.H. J. Nucl. Med. (1975) [Pubmed]
  37. Nuclear factor kappaB and anesthetic preconditioning during myocardial ischemia-reperfusion. Zhong, C., Zhou, Y., Liu, H. Anesthesiology (2004) [Pubmed]
  38. The ultrastructure of the accessory sex organs of the male rat. XI. Nuclear alterations of prostatic epithelial cells induced by castration. Dahl, E. Cell Tissue Res. (1976) [Pubmed]
  39. Quantitative imaging microscopy for the sensitive detection of administered metal containing drugs in single cells and tissue slices--a demonstration using platinum based chemotherapeutic agent. Mauthe, R.J., Sideras-Haddad, E., Turteltaub, K.W., Bench, G. Journal of pharmaceutical and biomedical analysis. (1998) [Pubmed]
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