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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Table of contents

About

Terms

 

Gene Review: 

CANT1  -  calcium activated nucleotidase 1

Homo sapiens

Synonyms: Apyrase homolog, DBQD, SCAN-1, SCAN1, SHAPY, ...
 
 
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Disease relevance of CANT1

 

High impact information on CANT1

  • Calcium-dependent Dimerization of Human Soluble Calcium Activated Nucleotidase: CHARACTERIZATION OF THE DIMER INTERFACE [4].
  • Genetics of Recurrent Early-Onset Major Depression (GenRED): Final Genome Scan Report [5].
  • Our siRNA Scan tool is useful to design better constructs for PTGS by minimizing off-target gene silencing in both plants and animals [6].
  • Multidetector CT of Pancreas: Effects of Contrast Material Flow Rate and Individualized Scan Delay on Enhancement of Pancreas and Tumor Contrast [7].
  • A newly discovered human analogue of a bed bug apyrase, which we named hSCAN-1 for human soluble calcium-activated nucleotidase-1, was expressed in bacteria, refolded from inclusion bodies, purified, and characterized [8].
  • CANT1 seems to have a role in protein quality control. CANT1 has been identified as a novel target of the Calcium-dependent transcriptional repressor DREAM. CANT1 downregulation increased protein degradation. CANT1 overexpression enhances Calcium levels in Golgi apparatus, indicating a role in Calcium homeostasis. Protein degradation represents a novel process modulated by DREAM. [9]
 

Biological context of CANT1

  • Seasonal variations in rates of birthweight = 4000g were calculated using Ratchet Circular Scan Test for a short seasonal peak [10].
 

Anatomical context of CANT1

  • An "All-Comers" Venous Duplex Scan Policy for Patients with Lower Limb Varicose Veins Attending a One-stop Vascular Clinic: Is It Justified [11]?
 

Analytical, diagnostic and therapeutic context of CANT1

  • METHOD: The patient underwent a radioimmunoscintigraphy with Anti-alpha FP antibody scan (AFP-Scan) [12].
  • Patients and methods We analyzed the cumulative revision rate for 1,720 Scan Hip arthroplasties with either 22-mm or 32-mm femoral heads [13].

References

  1. Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. El-Khamisy, S.F., Saifi, G.M., Weinfeld, M., Johansson, F., Helleday, T., Lupski, J.R., Caldecott, K.W. Nature (2005) [Pubmed]
  2. Prognostic Value of Computerized Tomography Scan Characteristics in Traumatic Brain Injury: Results from The IMPACT Study. Maas, A.I., Steyerberg, E.W., Butcher, I., Dammers, R., Lu, J., Marmarou, A., Mushkudiani, N.A., McHugh, G.S., Murray, G.D. J. Neurotrauma (2007) [Pubmed]
  3. Hemifacial spasm: case report. Jowi, J.O., Matende, J., Macharia, M.I. East African medical journal (2006) [Pubmed]
  4. Calcium-dependent Dimerization of Human Soluble Calcium Activated Nucleotidase: CHARACTERIZATION OF THE DIMER INTERFACE. Yang, M., Horii, K., Herr, A.B., Kirley, T.L. J. Biol. Chem. (2006) [Pubmed]
  5. Genetics of Recurrent Early-Onset Major Depression (GenRED): Final Genome Scan Report. Holmans, P., Weissman, M.M., Zubenko, G.S., Scheftner, W.A., Crowe, R.R., Depaulo, J.R., Knowles, J.A., Zubenko, W.N., Murphy-Eberenz, K., Marta, D.H., Boutelle, S., McInnis, M.G., Adams, P., Gladis, M., Steele, J., Miller, E.B., Potash, J.B., Mackinnon, D.F., Levinson, D.F. The American journal of psychiatry (2007) [Pubmed]
  6. Computational Estimation and Experimental Verification of Off-Target Silencing during Posttranscriptional Gene Silencing in Plants. Xu, P., Zhang, Y., Kang, L., Roossinck, M.J., Mysore, K.S. Plant Physiol. (2006) [Pubmed]
  7. Multidetector CT of Pancreas: Effects of Contrast Material Flow Rate and Individualized Scan Delay on Enhancement of Pancreas and Tumor Contrast. Schueller, G., Schima, W., Schueller-Weidekamm, C., Weber, M., Stift, A., Gnant, M., Prokesch, R. Radiology. (2006) [Pubmed]
  8. Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase. Murphy, D.M., Ivanenkov, V.V., Kirley, T.L. Biochemistry (2003) [Pubmed]
  9. Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (Downstream Regulatory Element Antagonist Modulator), is involved in protein folding and degradation. Cali, T., Fedrizzi, L., Ottolini, D., Gomez-Villafuertes, R., Mellstrom, B., Naranjo, J.R., Carafoli, E., Brini, M. J. Biol. Chem. (2012) [Pubmed]
  10. Seasonality and other variation trends in birth weights of 4000g and above: A preliminary report from the University of Port Harcourt Teaching Hospital, Nigeria. Akani, N.A., John, C.T., Oruamabo, R.S. Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria (2006) [Pubmed]
  11. An "All-Comers" Venous Duplex Scan Policy for Patients with Lower Limb Varicose Veins Attending a One-stop Vascular Clinic: Is It Justified? Makris, S.A., Karkos, C.D., Awad, S., London, N.J. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2006) [Pubmed]
  12. Diagnostic value of anti-alpha FP antibody levels in a metastatic germ cell tumor of unknown primary site. Malamitsi, J., Stathopoulos, G., Kittas, C., Chorti, M., Colialexi, A., Hadziyannis, S., Proukakis, C. Anticancer Res. (1999) [Pubmed]
  13. Femoral head diameter affects the revision rate in total hip arthroplasty: An analysis of 1,720 hip replacements with 9-21 years of follow-up. Tarasevicius, S., Kesteris, U., Robertsson, O., Wingstrand, H. Acta orthopaedica. (2006) [Pubmed]
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