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Gene Review

cyaA  -  adenylate cyclase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of cyaA


High impact information on cyaA


Biological context of cyaA

  • Moreover, adenylate cyclase activity in vivo was less sensitive to regulation by glucose, possibly because the enzyme II complexes of the phosphotransferase system, responsible for glucose transport and phosphorylation, could not be induced to maximal levels [4].
  • These suppressor mutations were traced to the crp locus and tentatively designated as acr (adenylate cyclase regulation) mutations [5].
  • A strain of Salmonella typhimurium that is highly virulent for 1-day-old white leghorn chicks was genetically modified by deletion (delta) of the adenylate cyclase (cya) and cyclic AMP receptor protein (crp) genes or by removal (curing) of the 91-kilobase virulence plasmid [6].

Anatomical context of cyaA


Associations of cyaA with chemical compounds

  • A cya mutation (adenylate cyclase deficiency) introduced into the leu-500 leu-2012 strain caused leu enzymes to be made only if cAMP was supplied exogenously [8].

Regulatory relationships of cyaA

  • In contrast, spvB transcription in stationary-phase cultures was enhanced by 10-fold in mutants deficient in crp-encoded CRP or cya-encoded adenylate cyclase [9].

Analytical, diagnostic and therapeutic context of cyaA


  1. Pathogenesis of Salmonella-mediated intestinal fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin. Giannella, R.A., Gots, R.E., Charney, A.N., Greenough, W.B., Formal, S.B. Gastroenterology (1975) [Pubmed]
  2. Molecular cloning and amplification of the adenylate cyclase gene. Wang, J.Y., Clegg, D.O., Koshland, D.E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  3. Coordinate regulation of adenylate cyclase and carbohydrate permeases by the phosphoenolpyruvate:sugar phosphotransferase system in Salmonella typhimurium. Saier, M.H., Feucht, B.U. J. Biol. Chem. (1975) [Pubmed]
  4. Effects of crp mutations on adenosine 3',5'-monophosphate metabolism in Salmonella typhimurium. Rephaeli, A.W., Saier, M.H. J. Bacteriol. (1976) [Pubmed]
  5. Regulatory interactions among the cya, crp and pts gene products in Salmonella typhimurium. Dobrogosz, W.J., Hall, G.W., Sherba, D.K., Silva, D.O., Harman, J.G., Melton, T. Mol. Gen. Genet. (1983) [Pubmed]
  6. Virulence of Salmonella typhimurium mutants for White Leghorn chicks. Porter, S.B., Tinge, S.A., Curtiss, R. Avian Dis. (1993) [Pubmed]
  7. The role of cAMP in flagellation of Salmonella typhimurium. Komeda, Y., Suzuki, H., Ishidsu, J.I., Iino, T. Mol. Gen. Genet. (1976) [Pubmed]
  8. Promoter mutation causing catabolite repression of the Salmonella typhimurium leucine operon. Gemmill, R.M., Tripp, M., Friedman, S.B., Calvo, J.M. J. Bacteriol. (1984) [Pubmed]
  9. The spv virulence operon of Salmonella typhimurium LT2 is regulated negatively by the cyclic AMP (cAMP)-cAMP receptor protein system. O'Byrne, C.P., Dorman, C.J. J. Bacteriol. (1994) [Pubmed]
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