The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

UHMK1  -  U2AF homology motif (UHM) kinase 1

Homo sapiens

Synonyms: KIS, KIST, Kinase interacting with stathmin, Kist, P-CIP2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of UHMK1

  • Affinity-purified antibodies recognizing KIS, ARK and ESY but not YRV, MGN or prebleed IgG specifically detected gp91(phox) in immunoblot analysis [1].

High impact information on UHMK1

  • Through phosphorylation of p27(Kip1) on S10, hKIS regulates cell cycle progression in response to mitogens [2].
  • RESULTS: We detected positive allelic association after the eighth marker was genotyped and found that three microsatellite markers (p = .011, p = .014, p = .049) and two SNPs (p = .004, p = .043) localized in the 700 kb region between the RGS4 and CAPON genes, within the UHMK1 gene, were associated with schizophrenia [3].
  • Fine Mapping by Genetic Association Implicates the Chromosome 1q23.3 Gene UHMK1, Encoding a Serine/Threonine Protein Kinase, as a Novel Schizophrenia Susceptibility Gene [3].
  • UHMK1 is a serine threonine kinase nuclear protein and is highly expressed in regions of the brain implicated in schizophrenia [3].
  • Antibodies recognizing MGN, ESY, ARK and KIS but not YRV or the prebleed IgG fraction labeled intact normal neutrophils [1].

Anatomical context of UHMK1

  • By inhibiting AKT and human kinase interacting stathmin (hKIS), trastuzumab blocks Thr157-, Thr198- and Ser10-induced p27Kip1 translocation from the nucleus to the cytosol, which increases the inhibitory effect of p27Kip1 [4].

Analytical, diagnostic and therapeutic context of UHMK1

  • These findings suggest that, when the effects of acclimatization and covariance of body height were taken into account, CBS was as reliable and reproducible as KIS in our laboratory [5].


  1. Unusual polyclonal anti-gp91 peptide antibody interactions with X-linked chronic granulomatous disease-derived human neutrophils are not from compensatory expression of Nox proteins 1, 3, or 4. Baniulis, D., Nauseef, W.M., Burritt, J.B., Taylor, R.M., Heyworth, P.G., Dinauer, M.C., Bumelis, V.A., Magnusson, K.E., Jesaitis, A.J. Eur. J. Haematol. (2005) [Pubmed]
  2. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. Boehm, M., Yoshimoto, T., Crook, M.F., Nallamshetty, S., True, A., Nabel, G.J., Nabel, E.G. EMBO J. (2002) [Pubmed]
  3. Fine Mapping by Genetic Association Implicates the Chromosome 1q23.3 Gene UHMK1, Encoding a Serine/Threonine Protein Kinase, as a Novel Schizophrenia Susceptibility Gene. Puri, V., McQuillin, A., Choudhury, K., Datta, S., Pimm, J., Thirumalai, S., Krasucki, R., Lawrence, J., Quested, D., Bass, N., Moorey, H., Morgan, J., Punukollu, B., Kandasami, G., Curtis, D., Gurling, H. Biol. Psychiatry (2007) [Pubmed]
  4. HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways. Le, X.F., Pruefer, F., Bast, R.C. Cell Cycle (2005) [Pubmed]
  5. Comparison of Kistler 9861A force platform and Chattecx Balance System for measurement of postural sway: correlation and test-retest reliability. Rogind, H., Simonsen, H., Era, P., Bliddal, H. Scandinavian journal of medicine & science in sports. (2003) [Pubmed]
WikiGenes - Universities