Gene Review:
RGS4 - regulator of G-protein signaling 4
Homo sapiens
Synonyms:
RGP4, Regulator of G-protein signaling 4, SCZD9
Wieland,
Mittmann,
Lipska,
Mitkus,
Caruso,
Hyde,
Chen,
Vakkalanka,
Straub,
Weinberger,
Kleinman,
Richardson,
Marjoram,
Barr,
Snyderman,
Witt-Enderby,
Jarzynka,
Krawitt,
Melan,
- Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. Chatterjee, T.K., Fisher, R.A. J. Biol. Chem. (2000)
- Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure. Owen, V.J., Burton, P.B., Mullen, A.J., Birks, E.J., Barton, P., Yacoub, M.H. Eur. Heart J. (2001)
- RGS3 and RGS4 are GTPase activating proteins in the heart. Zhang, S., Watson, N., Zahner, J., Rottman, J.N., Blumer, K.J., Muslin, A.J. J. Mol. Cell. Cardiol. (1998)
- RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity. Lipska, B.K., Mitkus, S., Caruso, M., Hyde, T.M., Chen, J., Vakkalanka, R., Straub, R.E., Weinberger, D.R., Kleinman, J.E. Hum. Mol. Genet. (2006)
- Differences in regional and subcellular localization of G(q/11) and RGS4 protein levels in Alzheimer's disease: correlation with muscarinic M1 receptor binding parameters. Muma, N.A., Mariyappa, R., Williams, K., Lee, J.M. Synapse (2003)
- GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Berman, D.M., Wilkie, T.M., Gilman, A.G. Cell (1996)
- PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel. Ishii, M., Inanobe, A., Kurachi, Y. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae. Srinivasa, S.P., Bernstein, L.S., Blumer, K.J., Linder, M.E. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Activation of extracellular signal-regulated kinase (ERK) and Akt by human serotonin 5-HT(1B) receptors in transfected BE(2)-C neuroblastoma cells is inhibited by RGS4. Leone, A.M., Errico, M., Lin, S.L., Cowen, D.S., Lione, A.M. J. Neurochem. (2000)
- Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor. Tovey, S.C., Willars, G.B. Mol. Pharmacol. (2004)
- RGS2/G0S8 is a selective inhibitor of Gqalpha function. Heximer, S.P., Watson, N., Linder, M.E., Blumer, K.J., Hepler, J.R. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions. Roy, A.A., Lemberg, K.E., Chidiac, P. Mol. Pharmacol. (2003)
- RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. Sullivan, B.M., Harrison-Lavoie, K.J., Marshansky, V., Lin, H.Y., Kehrl, J.H., Ausiello, D.A., Brown, D., Druey, K.M. Mol. Biol. Cell (2000)
- N-Terminal Residues Control Proteasomal Degradation of RGS2, RGS4, and RGS5 in Human Embryonic Kidney 293 Cells. Bodenstein, J., Sunahara, R.K., Neubig, R.R. Mol. Pharmacol. (2007)
- Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers. Contribution of location and/or orientation to Gtpase-activating protein activity. Tu, Y., Woodson, J., Ross, E.M. J. Biol. Chem. (2001)
- G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling. Dhami, G.K., Dale, L.B., Anborgh, P.H., O'Connor-Halligan, K.E., Sterne-Marr, R., Ferguson, S.S. J. Biol. Chem. (2004)
- RGS3 and RGS4 Differentially Associate with G Protein-coupled Receptor-Kir3 Channel Signaling Complexes Revealing Two Modes of RGS Modulation: PRECOUPLING AND COLLISION COUPLING. Ja??n, C., Doupnik, C.A. J. Biol. Chem. (2006)
- MS/NMR: a structure-based approach for discovering protein ligands and for drug design by coupling size exclusion chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy. Moy, F.J., Haraki, K., Mobilio, D., Walker, G., Powers, R., Tabei, K., Tong, H., Siegel, M.M. Anal. Chem. (2001)
- RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. Richardson, R.M., Marjoram, R.J., Barr, A.J., Snyderman, R. Biochemistry (2001)
- Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. Osterhout, J.L., Waheed, A.A., Hiol, A., Ward, R.J., Davey, P.C., Nini, L., Wang, J., Milligan, G., Jones, T.L., Druey, K.M. J. Biol. Chem. (2003)
- RGS3 is a GTPase-activating protein for g(ialpha) and g(qalpha) and a potent inhibitor of signaling by GTPase-deficient forms of g(qalpha) and g(11alpha). Scheschonka, A., Dessauer, C.W., Sinnarajah, S., Chidiac, P., Shi, C.S., Kehrl, J.H. Mol. Pharmacol. (2000)
- A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene loci. Winantea, J., Hoang, M.N., Ohlraun, S., Rietschel, M., Cichon, S., Propping, P., Nöthen, M.M., Freudenberg, J., Freudenberg-Hua, Y. Eur. J. Hum. Genet. (2006)
- Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling. Druey, K.M., Ugur, O., Caron, J.M., Chen, C.K., Backlund, P.S., Jones, T.L. J. Biol. Chem. (1999)
- Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system. Wieland, T., Mittmann, C. Pharmacol. Ther. (2003)
- RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells. Shuey, D.J., Betty, M., Jones, P.G., Khawaja, X.Z., Cockett, M.I. J. Neurochem. (1998)
- Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization. Witt-Enderby, P.A., Jarzynka, M.J., Krawitt, B.J., Melan, M.A. Life Sci. (2004)
- The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro. Popov, S., Yu, K., Kozasa, T., Wilkie, T.M. Proc. Natl. Acad. Sci. U.S.A. (1997)