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Gene Review

Clu  -  clusterin

Mus musculus

Synonyms: AI893575, Apo-J, ApoJ, Apoj, Apolipoprotein J, ...
 
 
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Disease relevance of Clu

 

Psychiatry related information on Clu

 

High impact information on Clu

 

Chemical compound and disease context of Clu

  • Furthermore, we investigated the cellular response to injury caused by methoxyacetic acid (MAA) toxicity and mild heat exposure in the cluKO mice to determine the extent to which clusterin protects against apoptosis or participates in tissue remodeling [8].
  • Furthermore, after the orthotopic implantation of KoTCC-1 cells, combined treatment with AS clusterin and cisplatin significantly inhibited the growth of primary KoTCC-1 tumors, as well as the incidence of lymph node metastasis [9].
  • Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model [10].
 

Biological context of Clu

 

Anatomical context of Clu

 

Associations of Clu with chemical compounds

 

Co-localisations of Clu

 

Regulatory relationships of Clu

  • Using cDNA differential display, we identified clusterin as a prominently induced gene in a Cdx2-regulated cellular model of intestinal differentiation [19].
  • EGF inhibits expression of WDNM1 and sulfated glycoprotein-2 genes in mammary epithelial cells [20].
  • Since the novel form of clusterin is also expressed in cells exposed to TGFbeta, colchicine, staurosporine, and azide, it may result from toxin-induced disruption of processes of normal cellular protein production [21].
  • Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo [22].
  • Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration [23].
 

Other interactions of Clu

  • IC(50) doses of EGCG for 24 h caused caspase cascade activation and CLU protein accumulation in both cells lines but not in normal cells, in which CLU remained undetectable [11].
  • Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse [17].
  • The purpose of this study was to investigate the relationship between the occurrence of apoptosis in the mouse limb during normal and abnormal development as well as the expression of tissue transglutaminase and clusterin, two proteins associated with apoptotic cell death [17].
  • The opposite but parallel responses in the expression of the EGF and SGP-2 genes suggest that their regulation is coupled to the initial injury-induced dedifferentiation and subsequent return to the fully differentiated state [18].
  • TRPM-2/clusterin mRNA levels in vitiligo neural retinas were similar to controls initially but were two times greater than controls by 12 weeks [16].
 

Analytical, diagnostic and therapeutic context of Clu

References

  1. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Han, B.H., DeMattos, R.B., Dugan, L.L., Kim-Han, J.S., Brendza, R.P., Fryer, J.D., Kierson, M., Cirrito, J., Quick, K., Harmony, J.A., Aronow, B.J., Holtzman, D.M. Nat. Med. (2001) [Pubmed]
  2. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. DeMattos, R.B., Cirrito, J.R., Parsadanian, M., May, P.C., O'Dell, M.A., Taylor, J.W., Harmony, J.A., Aronow, B.J., Bales, K.R., Paul, S.M., Holtzman, D.M. Neuron (2004) [Pubmed]
  3. The SGP-2 gene is developmentally regulated in the mouse kidney and abnormally expressed in collecting duct cysts in polycystic kidney disease. Harding, M.A., Chadwick, L.J., Gattone, V.H., Calvet, J.P. Dev. Biol. (1991) [Pubmed]
  4. Epidermal growth factor ameliorates autosomal recessive polycystic kidney disease in mice. Gattone, V.H., Lowden, D.A., Cowley, B.D. Dev. Biol. (1995) [Pubmed]
  5. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. DeMattos, R.B., O'dell, M.A., Parsadanian, M., Taylor, J.W., Harmony, J.A., Bales, K.R., Paul, S.M., Aronow, B.J., Holtzman, D.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Immunocytochemical colocalization of clusterin in apoptotic photoreceptor cells in retinal degeneration slow rds mutant mouse retinas. Agarwal, N., Jomary, C., Jones, S.E., O'Rourke, K., Chaitin, M., Wordinger, R.J., Murphy, B.F. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  7. Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis. McLaughlin, L., Zhu, G., Mistry, M., Ley-Ebert, C., Stuart, W.D., Florio, C.J., Groen, P.A., Witt, S.A., Kimball, T.R., Witte, D.P., Harmony, J.A., Aronow, B.J. J. Clin. Invest. (2000) [Pubmed]
  8. Heat shock-initiated apoptosis is accelerated and removal of damaged cells is delayed in the testis of clusterin/ApoJ knock-out mice. Bailey, R.W., Aronow, B., Harmony, J.A., Griswold, M.D. Biol. Reprod. (2002) [Pubmed]
  9. Synergistic chemsensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model. Miyake, H., Hara, I., Kamidono, S., Gleave, M.E. Clin. Cancer Res. (2001) [Pubmed]
  10. Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model. Yamanaka, K., Gleave, M.E., Hara, I., Muramaki, M., Miyake, H. Mol. Cancer Ther. (2005) [Pubmed]
  11. The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Caporali, A., Davalli, P., Astancolle, S., D'Arca, D., Brausi, M., Bettuzzi, S., Corti, A. Carcinogenesis (2004) [Pubmed]
  12. Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization). White, R.A., Dowler, L.L., Pasztor, L.M., Gatson, L.L., Adkison, L.R., Angeloni, S.V., Wilson, D.B. Genomics (1995) [Pubmed]
  13. Low density lipoprotein receptor-related protein-2 expression in efferent duct and epididymal epithelia: evidence in rats for its in vivo role in endocytosis of apolipoprotein J/clusterin. Morales, C.R., Igdoura, S.A., Wosu, U.A., Boman, J., Argraves, W.S. Biol. Reprod. (1996) [Pubmed]
  14. Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis. Jordan-Starck, T.C., Lund, S.D., Witte, D.P., Aronow, B.J., Ley, C.A., Stuart, W.D., Swertfeger, D.K., Clayton, L.R., Sells, S.F., Paigen, B. J. Lipid Res. (1994) [Pubmed]
  15. Changes in levels of mRNAs of transforming growth factor (TGF)-beta1, -beta2, -beta3, TGF-beta type II receptor and sulfated glycoprotein-2 during apoptosis of mouse uterine epithelium. Wada, K., Nomura, S., Morii, E., Kitamura, Y., Nishizawa, Y., Miyake, A., Terada, N. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  16. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Smith, S.B., Bora, N., McCool, D., Kutty, G., Wong, P., Kutty, R.K., Wiggert, B. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  17. Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse. Adel Moallem, S., Hales, B.F. Biol. Reprod. (1996) [Pubmed]
  18. Primary and secondary genetic responses after folic acid-induced acute renal injury in the mouse. Calvet, J.P., Chadwick, L.J. J. Am. Soc. Nephrol. (1994) [Pubmed]
  19. Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium. Suh, E., Wang, Z., Swain, G.P., Tenniswood, M., Traber, P.G. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  20. EGF inhibits expression of WDNM1 and sulfated glycoprotein-2 genes in mammary epithelial cells. Lee, M., Hwang, I., Choi, Y., Paik, S., Lee, H.B., Baik, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  21. Effects of clusterin overexpression on TNFalpha- and TGFbeta-mediated death of L929 cells. Humphreys, D., Hochgrebe, T.T., Easterbrook-Smith, S.B., Tenniswood, M.P., Wilson, M.R. Biochemistry (1997) [Pubmed]
  22. Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. Thomas-Tikhonenko, A., Viard-Leveugle, I., Dews, M., Wehrli, P., Sevignani, C., Yu, D., Ricci, S., el-Deiry, W., Aronow, B., Kaya, G., Saurat, J.H., French, L.E. Cancer Res. (2004) [Pubmed]
  23. Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. Forte, T.M., Oda, M.N., Knoff, L., Frei, B., Suh, J., Harmony, J.A., Stuart, W.D., Rubin, E.M., Ng, D.S. J. Lipid Res. (1999) [Pubmed]
  24. Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis. French, L.E., Chonn, A., Ducrest, D., Baumann, B., Belin, D., Wohlwend, A., Kiss, J.Z., Sappino, A.P., Tschopp, J., Schifferli, J.A. J. Cell Biol. (1993) [Pubmed]
 
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