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Gene Review

STXBP5  -  syntaxin binding protein 5 (tomosyn)

Homo sapiens

Synonyms: LGL3, LLGL3, Lethal(2) giant larvae protein homolog 3, Nbla04300, Syntaxin-binding protein 5, ...
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High impact information on STXBP5


Biological context of STXBP5


Other interactions of STXBP5

  • Characterization of tom-1 mutants suggests that TOM-1, the C. elegans ortholog of mammalian tomosyn, functions as an endogenous inhibitor of neurotransmitter secretion [3].

Analytical, diagnostic and therapeutic context of STXBP5

  • Using atomic force microscopy we show that the SNARE-like domain of tomosyn-1 can form a complex with syntaxin-1 and SNAP25 but displays binding forces that are weaker than those observed for VAMP2 (237+/-13 versus 279+/-3 pN) [2].


  1. Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Fujita, Y., Shirataki, H., Sakisaka, T., Asakura, T., Ohya, T., Kotani, H., Yokoyama, S., Nishioka, H., Matsuura, Y., Mizoguchi, A., Scheller, R.H., Takai, Y. Neuron (1998) [Pubmed]
  2. Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis. Cheviet, S., Bezzi, P., Ivarsson, R., Renström, E., Viertl, D., Kasas, S., Catsicas, S., Regazzi, R. J. Cell. Sci. (2006) [Pubmed]
  3. Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion. Dybbs, M., Ngai, J., Kaplan, J.M. PLoS Genet. (2005) [Pubmed]
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