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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Secretory Rate

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Disease relevance of Secretory Rate


Psychiatry related information on Secretory Rate


High impact information on Secretory Rate


Chemical compound and disease context of Secretory Rate


Biological context of Secretory Rate


Anatomical context of Secretory Rate

  • D-feeding did not prevent E-induced decrease of basal bile flow, bile salt, cholesterol, and phospholipid secretory rates nor the decrease of Na+,K+-ATPase activity and Na+-taurocholate cotransporting polypeptide (Ntcp) content in isolated sinusoidal membranes [23].
  • CTB and CT did not increase the secretory rate of IgA-producing cells or the clonal burst size of IgA clones, and did inhibit B cell growth [24].
  • Alkali secretion by rat duodenum was also increased by sucralfate but the response depended on the basal secretory rate [25].
  • Mucin secretory rate per unit surface area of trachea progressively decreases with age [26].
  • Each drug tested was administered i.a. Graded doses of gabexate (1-10 mg) elicited dose-dependent biphasic responses for the secretory rates, bicarbonate concentrations and outputs of pancreatic juice, with maximum effects at approximately 5 mg, but had little effect on the protein concentrations [27].

Associations of Secretory Rate with chemical compounds

  • However, as FFA uptake increases, triglyceride secretory rates reach a plateau and esterified fatty acids accumulate intracellularly, suggesting that something is limiting lipid transport out of the liver [12].
  • Tolbutamide elicited typical monophasic insulin release that exceeded control islet secretory rates from 2 to 6 min with a peak value at 3 min [28].
  • Histamine and N tau-methyl histamine secretory rates were calculated by subtracting the arterial from the venous plasma concentrations and multiplying the difference by gastric plasma flow [29].
  • Fundic distention with a baloon volume eliciting a maximal acid response to distention either left unchanged or suppressed the maximal acid secretory rate produced by pentagastrin in 7 nonoperated and 6 vagotomized DU patients and in 5 healthy subjects [30].
  • Measurements of lactate, pyruvate, and CO2 appearances indicated that the increases in acid secretory rates were predominantly due to H+ and not organic acid accumulation in the luminal bath-secretion [31].

Gene context of Secretory Rate

  • No evidence for overproduction of IAPP in diabetic subjects has been found thus far, but much more work is necessary to define its normal secretory rates and clearance [32].
  • Results from this experiment reveal partial immunoneutralization of intrapituitary VIP significantly decreased PRL secretory rate by rapid reduction in rRPL mRNA in the 40-day tumors [33].
  • In three of them, a decrease of 20% to 51% of the PRL basal secretory rate was observed under GAP [34].
  • Neither the secretory rates of thyrotropin in response to TRH nor those of cortisol, luteinizing hormone, or follicle-stimulating hormone were changed by 0.1 or 0.35 mg mesulergine.(ABSTRACT TRUNCATED AT 250 WORDS)[35]
  • The relative secretory rate (RSR) of these glycoproteins is assessed after incubation with 50% (v/v) CF and control sera [36].

Analytical, diagnostic and therapeutic context of Secretory Rate

  • Bile formation was studied under basal conditions and during stepwise increasing intravenous infusion of taurocholate to determine bile salt secretory rate maximum (SRm) [37].
  • Renin secretory rate decreased in the low-output group from 852.8 +/- 183.0 to 149.5 +/- 73.7 ng/min and in the control group from 308.5 +/- 84.5 to 44.5 +/- 27.5 ng/ml [38].
  • A significant, although not systematic, association between the episodes in the two variables was found: 44% of the peaks in EEG beta activity (relative amplitude, near 125%; P < 0.001) occurred during an ascending phase of cortisol secretion, cortisol secretory rates increasing by 40% (P < 0.01) 10-min after peaks in EEG beta activity [39].
  • The secretory rate of ANP and BNP were examined in the perfusion of isolated beating heart before and after atrial removal [40].
  • Cortisol was assayed by HPLC with UV detection, and adrenal secretory rates were calculated using adrenal blood flow [41].


  1. Gastric secretion and emptying after ordinary meals in duodenal ulcer. Malagelada, J.R., Longstreth, G.F., Deering, T.B., Summerskill, W.H., Go, V.L. Gastroenterology (1977) [Pubmed]
  2. Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension. Benraad, H., Drayer, J., Hoefnagels, W., Kloppenborg, P., Benraad, T. Clin. Pharmacol. Ther. (1978) [Pubmed]
  3. The pituitary-adrenocortical response to hemorrhage depends on the time of day. Engeland, W.C., Byrnes, G.J., Gann, D.S. Endocrinology (1982) [Pubmed]
  4. The effects of recombinant human insulin-like growth factor I on growth hormone secretion in adolescents with insulin dependent diabetes mellitus. Cheetham, T.D., Clayton, K.L., Taylor, A.M., Holly, J., Matthews, D.R., Dunger, D.B. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
  5. Salivary secretion assay for drug efficacy for cystic fibrosis in mice. Best, J.A., Quinton, P.M. Exp. Physiol. (2005) [Pubmed]
  6. Prolactin secretion and sleep. Spiegel, K., Follenius, M., Simon, C., Saini, J., Ehrhart, J., Brandenberger, G. Sleep. (1994) [Pubmed]
  7. Pulsatile cortisol secretion and EEG delta waves are controlled by two independent but synchronized generators. Gronfier, C., Chapotot, F., Weibel, L., Jouny, C., Piquard, F., Brandenberger, G. Am. J. Physiol. (1998) [Pubmed]
  8. Cyproheptadine-induced remission of Cushing's disease. Krieger, D.T., Amorosa, L., Linick, F. N. Engl. J. Med. (1975) [Pubmed]
  9. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. Oude Elferink, R.P., Ottenhoff, R., van Wijland, M., Smit, J.J., Schinkel, A.H., Groen, A.K. J. Clin. Invest. (1995) [Pubmed]
  10. Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines. Farrell, W.E., Clark, A.J., Stewart, M.F., Crosby, S.R., White, A. J. Clin. Invest. (1992) [Pubmed]
  11. Plasma growth hormone responses to constant infusions of human pancreatic growth hormone releasing factor. Intermittent secretion or response attenuation. Webb, C.B., Vance, M.L., Thorner, M.O., Perisutti, G., Thominet, J., Rivier, J., Vale, W., Frohman, L.A. J. Clin. Invest. (1984) [Pubmed]
  12. Effect of fatty acids on lipid and apoprotein secretion and association in hepatocyte cultures. Patsch, W., Tamai, T., Schonfeld, G. J. Clin. Invest. (1983) [Pubmed]
  13. Increased cortisol secretion after small hemorrhage is not attributable to changes in adrenocorticotropin. Dempsher, D.P., Gann, D.S. Endocrinology (1983) [Pubmed]
  14. Effects of sub-chronic exposure to SO2 on lipid and carbohydrate metabolism in rats. Lovati, M.R., Manzoni, C., Daldossi, M., Spolti, S., Sirtori, C.R. Arch. Toxicol. (1996) [Pubmed]
  15. Renal handling of uric acid in man. Levinson, D.J., Decker, D.E., Sorensen, L.B. Ann. Clin. Lab. Sci. (1982) [Pubmed]
  16. Internal dissociation of the circadian markers of the cortisol rhythm in night workers. Weibel, L., Spiegel, K., Follenius, M., Ehrhart, J., Brandenberger, G. Am. J. Physiol. (1996) [Pubmed]
  17. Nature of bile acid maximum secretory rate in the rat. Hardison, W.G., Hatoff, D.E., Miyai, K., Weiner, R.G. Am. J. Physiol. (1981) [Pubmed]
  18. Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells. Randall, T.D., Brewer, J.W., Corley, R.B. J. Biol. Chem. (1992) [Pubmed]
  19. Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function, and the renin-aldosterone system in dogs. Maack, T., Marion, D.N., Camargo, M.J., Kleinert, H.D., Laragh, J.H., Vaughan, E.D., Atlas, S.A. Am. J. Med. (1984) [Pubmed]
  20. Modification of luteinizing hormone secretion by activators of Ca2+/phospholipid-dependent protein kinase. Turgeon, J.L., Waring, D.W. Endocrinology (1986) [Pubmed]
  21. Defective bile acid transport in an animal model of defective debrisoquine hydroxylation. Reichen, J., Krähenbühl, S., Küpfer, A., Sägesser, H., Karlaganis, G. Biochem. Pharmacol. (1986) [Pubmed]
  22. Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets. Panten, U., Burgfeld, J., Goerke, F., Rennicke, M., Schwanstecher, M., Wallasch, A., Zünkler, B.J., Lenzen, S. Biochem. Pharmacol. (1989) [Pubmed]
  23. Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat. Accatino, L., Pizarro, M., Solís, N., Koenig, C.S. Hepatology (1998) [Pubmed]
  24. Cholera toxin and cholera toxin B subunit induce IgA switching through the action of TGF-beta 1. Kim, P.H., Eckmann, L., Lee, W.J., Han, W., Kagnoff, M.F. J. Immunol. (1998) [Pubmed]
  25. Effect of bismuth subcitrate and sucralfate on rat duodenal and human gastric bicarbonate secretion in vivo. Shorrock, C.J., Garner, A., Hunter, A.H., Crampton, J.R., Rees, W.D. Gut (1990) [Pubmed]
  26. Developmental changes of ferret tracheal mucin composition and biosynthesis. Leigh, M.W., Cheng, P.W., Boat, T.F. Biochemistry (1989) [Pubmed]
  27. Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. Horiuchi, A., Iwatsuki, K., Yonekura, H., Ren, L.M., Chiba, S. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  28. Tolbutamide perifusion of rat islets. Sequential changes in calcium, phosphorus, sodium, potassium, and chlorine in single beta cells. Kalkhoff, R.K., Siegesmund, K.A., Dragen, R.F. J. Clin. Invest. (1983) [Pubmed]
  29. The role of gastric secretagogues in regulating gastric histamine release in vivo. Gerber, J.G., Payne, N.A. Gastroenterology (1992) [Pubmed]
  30. Effects of fundic distention on pentagastrin-stimulated gastric acid secretion in man. Grötzinger, U., Bergegårdh, S., Olbe, L. Gastroenterology (1977) [Pubmed]
  31. Effects of cyclic adenosine 3':5'-monophosphate and related agents on acid secretion by isolated rabbit gastric mucosa. Fromm, D., Schwartz, J.H., Quijano, R. Gastroenterology (1975) [Pubmed]
  32. Is islet amyloid polypeptide a significant factor in pathogenesis or pathophysiology of diabetes? Steiner, D.F., Ohagi, S., Nagamatsu, S., Bell, G.I., Nishi, M. Diabetes (1991) [Pubmed]
  33. Vasoactive intestinal polypeptide antiserum affects rat prolactin mRNA in 40-day but not 110-day diethylstilbestrol-induced prolactinoma tissue. Maas, D.L., Meier, D.A., Wahle, J.S., Martinson, D.R., Hagen, T.C. Mol. Cell. Neurosci. (1994) [Pubmed]
  34. Thyrotropin-releasing hormone and gonadotropin-releasing hormone-associated peptide modulation of [Ca2+]i in human lactotrophs. Dufy-Barbe, L., Bresson, L., Vacher, P., Odessa, M.F., San Galli, F., Rivel, J., Guérin, J. Mol. Cell. Endocrinol. (1993) [Pubmed]
  35. Mesulergine, a new dopamine agonist: effects on anterior pituitary function and kinetics. Borges, J.L., Schran, H.F., Evans, W.S., Rogol, A.D., Kaiser, D.L., MacLeod, R.M., Boyett, R.L., Elton, R.L., Thorner, M.O. Clin. Pharmacol. Ther. (1984) [Pubmed]
  36. Mucin release from rabbit tracheal epithelium in response to sera from normal and cystic fibrosis subjects. Boat, T.F., Polony, I., Cheng, P.W. Pediatr. Res. (1982) [Pubmed]
  37. Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. van Waarde, W.M., Verkade, H.J., Wolters, H., Havinga, R., Baller, J., Bloks, V., Müller, M., Sauer, P.J., Kuipers, F. Gastroenterology (2002) [Pubmed]
  38. Effects of synthetic atrial natriuretic peptide on renal function and renin release in acute experimental heart failure. Scriven, T.A., Burnett, J.C. Circulation (1985) [Pubmed]
  39. Cortisol secretion is related to electroencephalographic alertness in human subjects during daytime wakefulness. Chapotot, F., Gronfier, C., Jouny, C., Muzet, A., Brandenberger, G. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  40. Accelerated secretion of brain natriuretic peptide from the hypertrophied ventricles in experimental malignant hypertension. Kohno, M., Horio, T., Yoshiyama, M., Takeda, T. Hypertension (1992) [Pubmed]
  41. Dissociation between changes in plasma bioactive and immunoreactive adrenocorticotropin after hemorrhage in awake dogs. Engeland, W.C., Miller, P., Gann, D.S. Endocrinology (1989) [Pubmed]
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