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Stxbp5  -  syntaxin binding protein 5 (tomosyn)

Mus musculus

Synonyms: 0710001E20Rik, 4930565N16Rik, AW742610, Kiaa4253, LGL3, ...
 
 
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Analytical, diagnostic and therapeutic context of Stxbp5

  • To compare the expression pattern of tomosyn-1 and -2, we performed in situ hybridization experiments with gene-specific probes [4].
  • Western blotting revealed a 130-kDa protein corresponding to tomosyn in insulin-secreting beta-cell lines [1].
  • Using a yeast two-hybrid assay we demonstrate that the VAMP-2-like domain in Tomosyn facilitates the interaction with Syntaxin4 [2].
  • Using atomic force microscopy we show that the SNARE-like domain of tomosyn-1 can form a complex with syntaxin-1 and SNAP25 but displays binding forces that are weaker than those observed for VAMP2 (237+/-13 versus 279+/-3 pN) [3].

References

  1. Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis. Zhang, W., Lilja, L., Mandic, S.A., Gromada, J., Smidt, K., Janson, J., Takai, Y., Bark, C., Berggren, P.O., Meister, B. Diabetes (2006) [Pubmed]
  2. Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. Widberg, C.H., Bryant, N.J., Girotti, M., Rea, S., James, D.E. J. Biol. Chem. (2003) [Pubmed]
  3. Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis. Cheviet, S., Bezzi, P., Ivarsson, R., Renström, E., Viertl, D., Kasas, S., Catsicas, S., Regazzi, R. J. Cell. Sci. (2006) [Pubmed]
  4. Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain. Groffen, A.J., Jacobsen, L., Schut, D., Verhage, M. J. Neurochem. (2005) [Pubmed]
 
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