Gene Review:
Stxbp5 - syntaxin binding protein 5 (tomosyn)
Mus musculus
Synonyms:
0710001E20Rik, 4930565N16Rik, AW742610, Kiaa4253, LGL3, ...
- Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis. Zhang, W., Lilja, L., Mandic, S.A., Gromada, J., Smidt, K., Janson, J., Takai, Y., Bark, C., Berggren, P.O., Meister, B. Diabetes (2006)
- Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. Widberg, C.H., Bryant, N.J., Girotti, M., Rea, S., James, D.E. J. Biol. Chem. (2003)
- Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis. Cheviet, S., Bezzi, P., Ivarsson, R., Renström, E., Viertl, D., Kasas, S., Catsicas, S., Regazzi, R. J. Cell. Sci. (2006)
- Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain. Groffen, A.J., Jacobsen, L., Schut, D., Verhage, M. J. Neurochem. (2005)