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E2f5  -  E2F transcription factor 5

Mus musculus

Synonyms: AU024671, E2F-5, Transcription factor E2F5
 
 
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High impact information on E2f5

  • A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting [1].
  • Thus, E2F-5 is not essential for cell proliferation [1].
  • Thus, E2F4 and E2F5 are dispensable for cell cycle progression but necessary for pocket protein-mediated G1 arrest of cycling cells [2].
  • We find similar patterns of E2F regulation with both differentiating agents and demonstrate a switch in expression from E2F-1, -2, and -3 in undifferentiated, proliferating cells to E2F-5 in terminally differentiated keratinocytes [3].
  • Here, we report the isolation and characterisation of a new member of the E2F family of proteins, called E2F-5 [4].
 

Biological context of E2f5

 

Anatomical context of E2f5

  • E2F-1, E2F-2 and E2F-5 are first detected in the 9.5 days post-coitus (dpc) forebrain [6].
  • Moreover, E2F-5 CNS expression in normal animals was largely confined to the choroid plexus [1].
  • In contrast, E2F-5 transcripts were limited to the upper half of the villi and were absent in the intervillus epithelium [5].
 

Analytical, diagnostic and therapeutic context of E2f5

  • E2F-5 was isolated through a yeast two hybrid assay in which a 14.5 d.p.c. mouse embryo library was screened for molecules capable of binding to murine DP-1, but also interacts with all known members of the DP family of proteins [4].

References

  1. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Lindeman, G.J., Dagnino, L., Gaubatz, S., Xu, Y., Bronson, R.T., Warren, H.B., Livingston, D.M. Genes Dev. (1998) [Pubmed]
  2. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Gaubatz, S., Lindeman, G.J., Ishida, S., Jakoi, L., Nevins, J.R., Livingston, D.M., Rempel, R.E. Mol. Cell (2000) [Pubmed]
  3. Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation. D'Souza, S.J., Pajak, A., Balazsi, K., Dagnino, L. J. Biol. Chem. (2001) [Pubmed]
  4. Molecular and functional characterisation of E2F-5, a new member of the E2F family. Buck, V., Allen, K.E., Sørensen, T., Bybee, A., Hijmans, E.M., Voorhoeve, P.M., Bernards, R., La Thangue, N.B. Oncogene (1995) [Pubmed]
  5. Expression patterns of the E2F family of transcription factors during murine epithelial development. Dagnino, L., Fry, C.J., Bartley, S.M., Farnham, P., Gallie, B.L., Phillips, R.A. Cell Growth Differ. (1997) [Pubmed]
  6. Expression patterns of the E2F family of transcription factors during mouse nervous system development. Dagnino, L., Fry, C.J., Bartley, S.M., Farnham, P., Gallie, B.L., Phillips, R.A. Mech. Dev. (1997) [Pubmed]
 
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