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Gene Review

Ephb3  -  Eph receptor B3

Mus musculus

Synonyms: AW456895, Cek10, Developmental kinase 5, Ephrin type-B receptor 3, Etk2, ...
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Disease relevance of Ephb3

  • The phenotype in both axon tracts is markedly more severe in sek4/nuk1 double mutants, indicating that the two receptors act in a partially redundant fashion. sek4/nuk1 double mutants also exhibit specific guidance and fasciculation defects of diencephalic axon tracts [1].
  • Moreover, while mice singly deficient in either Sek4 or Nuk are viable, most sek4/nuk1 double mutants die immediately after birth primarily due to a cleft palate [1].

High impact information on Ephb3

  • While mice deficient in Nuk exhibit defects in pathfinding of anterior commissure axons, sek4 mutants have defects in corpus callosum formation [1].
  • Northern blot analyses of adult mouse tissues revealed a 4.7 kb transcript of MDK2 and a 4.8 kb transcript of MDK5 in various organ systems, including lung, liver, kidney, intestine, muscle, heart, and, in the case of MDK5, also the brain [2].
  • Northern blot analysis and in situ hybridization of mouse embryos indicated abundant expression during embryonic development, with preferential involvement of tissues of epithelial and endothelial origin for both kinases and of the spinal cord gray matter for MDK5 [2].
  • Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family [2].
  • A recently identified third transmembrane-type ligand, Elf3, specifically, but weakly, binds Cek10 and only induces focus formation when activated by C-terminal truncation [3].

Anatomical context of Ephb3


Analytical, diagnostic and therapeutic context of Ephb3

  • In this report, we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk) [4].


  1. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. Orioli, D., Henkemeyer, M., Lemke, G., Klein, R., Pawson, T. EMBO J. (1996) [Pubmed]
  2. Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family. Ciossek, T., Lerch, M.M., Ullrich, A. Oncogene (1995) [Pubmed]
  3. Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Brambilla, R., Brückner, K., Orioli, D., Bergemann, A.D., Flanagan, J.G., Klein, R. Mol. Cell. Neurosci. (1996) [Pubmed]
  4. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Ruiz, J.C., Conlon, F.L., Robertson, E.J. Mech. Dev. (1994) [Pubmed]
  5. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Becker, N., Seitanidou, T., Murphy, P., Mattéi, M.G., Topilko, P., Nieto, M.A., Wilkinson, D.G., Charnay, P., Gilardi-Hebenstreit, P. Mech. Dev. (1994) [Pubmed]
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