The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Igf2bp1  -  insulin-like growth factor 2 mRNA binding...

Mus musculus

Synonyms: AL024068, AW549074, CRD-BP, Coding region determinant-binding protein, Crdbp, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Igf2bp1

  • WAP-CRD-BP mice are a novel model for mammary neoplasia and might provide insights into human breast cancer biology [1].
  • CRD-BP is essential for the induction of both betaTrCP1 and c-Myc by beta-catenin signalling in colorectal cancer cells [2].
 

High impact information on Igf2bp1

 

Anatomical context of Igf2bp1

  • Only three of the nine transcripts analysed (Glut 5, Gpx 1 and Igf2bp1) were significantly down-regulated at blastocyst stage in in vitro produced controls [4].
  • From electron microscopic observations, elements of IMP-1 and IMP-1p are possibly corresponded to the fragments of filopodia of the parasites [5].
 

Analytical, diagnostic and therapeutic context of Igf2bp1

  • Among fractioned components of IMP, IMP-1, IMP-2, and imp-3, by gel filtration with Sephadex G-200, all of the mice immunized with IMP-1 antigen alone or together with FCA and challenged on day 5 were able to conquer intraperitoneal challenges with 1 x10(2) parasites [5].

References

  1. Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Tessier, C.R., Doyle, G.A., Clark, B.A., Pitot, H.C., Ross, J. Cancer Res. (2004) [Pubmed]
  2. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Noubissi, F.K., Elcheva, I., Bhatia, N., Shakoori, A., Ougolkov, A., Liu, J., Minamoto, T., Ross, J., Fuchs, S.Y., Spiegelman, V.S. Nature (2006) [Pubmed]
  3. Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro. Leeds, P., Kren, B.T., Boylan, J.M., Betz, N.A., Steer, C.J., Gruppuso, P.A., Ross, J. Oncogene (1997) [Pubmed]
  4. Differential effects of culture and nuclear transfer on relative transcript levels of genes with key roles during preimplantation. Moreira, P.N., Fernández-Gonzalez, R., Ramirez, M.A., Pérez-Crespo, M., Rizos, D., Pintado, B., Gutiérrez-Adán, A. Zygote (2006) [Pubmed]
  5. Protective immune response in mice immunized with antigens from Trypanosoma gambiense-infected mouse blood. Osaki, H., Furuya, M., Oka, M. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. (1979) [Pubmed]
 
WikiGenes - Universities