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Gene Review

Igf2bp1  -  insulin-like growth factor 2 mRNA binding...

Mus musculus

Synonyms: AL024068, AW549074, CRD-BP, Coding region determinant-binding protein, Crdbp, ...
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Disease relevance of Igf2bp1

  • WAP-CRD-BP mice are a novel model for mammary neoplasia and might provide insights into human breast cancer biology [1].
  • CRD-BP is essential for the induction of both betaTrCP1 and c-Myc by beta-catenin signalling in colorectal cancer cells [2].

High impact information on Igf2bp1


Anatomical context of Igf2bp1

  • Only three of the nine transcripts analysed (Glut 5, Gpx 1 and Igf2bp1) were significantly down-regulated at blastocyst stage in in vitro produced controls [4].
  • From electron microscopic observations, elements of IMP-1 and IMP-1p are possibly corresponded to the fragments of filopodia of the parasites [5].

Analytical, diagnostic and therapeutic context of Igf2bp1

  • Among fractioned components of IMP, IMP-1, IMP-2, and imp-3, by gel filtration with Sephadex G-200, all of the mice immunized with IMP-1 antigen alone or together with FCA and challenged on day 5 were able to conquer intraperitoneal challenges with 1 x10(2) parasites [5].


  1. Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Tessier, C.R., Doyle, G.A., Clark, B.A., Pitot, H.C., Ross, J. Cancer Res. (2004) [Pubmed]
  2. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Noubissi, F.K., Elcheva, I., Bhatia, N., Shakoori, A., Ougolkov, A., Liu, J., Minamoto, T., Ross, J., Fuchs, S.Y., Spiegelman, V.S. Nature (2006) [Pubmed]
  3. Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro. Leeds, P., Kren, B.T., Boylan, J.M., Betz, N.A., Steer, C.J., Gruppuso, P.A., Ross, J. Oncogene (1997) [Pubmed]
  4. Differential effects of culture and nuclear transfer on relative transcript levels of genes with key roles during preimplantation. Moreira, P.N., Fernández-Gonzalez, R., Ramirez, M.A., Pérez-Crespo, M., Rizos, D., Pintado, B., Gutiérrez-Adán, A. Zygote (2006) [Pubmed]
  5. Protective immune response in mice immunized with antigens from Trypanosoma gambiense-infected mouse blood. Osaki, H., Furuya, M., Oka, M. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. (1979) [Pubmed]
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