Disease relevance of Igf2bp1

• WAP-CRD-BP mice are a novel model for mammary neoplasia and might provide insights into human breast cancer biology [1].
• CRD-BP is essential for the induction of both betaTrCP1 and c-Myc by beta-catenin signalling in colorectal cancer cells [2].

High impact information on Igf2bp1

• To test this idea, the CRD-BP was expressed from the whey acidic protein (WAP) promoter in mammary epithelial cells of adult transgenic mice [1].
• These data suggest the CRD-BP is a proto-oncogene [1].
• CRD-BP levels are high during fetal development but low or undetectable in normal adult tissues [1].
• Its expression in fetal liver and in transformed cell lines suggests CRD-BP is an oncofetal protein [3].
• To our knowledge, CRD-BP is the first example of a putative mammalian mRNA-binding protein that is abundant in a fetal tissue but either absent from or scarce in adult tissues [3].

Anatomical context of Igf2bp1

• Only three of the nine transcripts analysed (Glut 5, Gpx 1 and Igf2bp1) were significantly down-regulated at blastocyst stage in in vitro produced controls [4].
• From electron microscopic observations, elements of IMP-1 and IMP-1p are possibly corresponded to the fragments of filopodia of the parasites [5].

Analytical, diagnostic and therapeutic context of Igf2bp1

• Among fractioned components of IMP, IMP-1, IMP-2, and imp-3, by gel filtration with Sephadex G-200, all of the mice immunized with IMP-1 antigen alone or together with FCA and challenged on day 5 were able to conquer intraperitoneal challenges with 1 x10(2) parasites [5].

References