Gene Review:
Wap - whey acidic protein
Mus musculus
Synonyms:
WAP, Whey acidic protein
- Transforming growth factor alpha- and c-myc-induced mammary carcinogenesis in transgenic mice. Rose-Hellekant, T.A., Sandgren, E.P. Oncogene (2000)
- Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Tessier, C.R., Doyle, G.A., Clark, B.A., Pitot, H.C., Ross, J. Cancer Res. (2004)
- Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. Gallego, M.I., Bierie, B., Hennighausen, L. Oncogene (2003)
- Whey acidic protein extrinsically expressed from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary development. Hennighausen, L., McKnight, R., Burdon, T., Baik, M., Wall, R.J., Smith, G.H. Cell Growth Differ. (1994)
- Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice. Andres, A.C., van der Valk, M.A., Schönenberger, C.A., Flückiger, F., LeMeur, M., Gerlinger, P., Groner, B. Genes Dev. (1988)
- Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands. Wang, R.A., Vadlamudi, R.K., Bagheri-Yarmand, R., Beuvink, I., Hynes, N.E., Kumar, R. J. Cell Biol. (2003)
- Perturbation of beta1-integrin function alters the development of murine mammary gland. Faraldo, M.M., Deugnier, M.A., Lukashev, M., Thiery, J.P., Glukhova, M.A. EMBO J. (1998)
- Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice. Lin, C.Q., Dempsey, P.J., Coffey, R.J., Bissell, M.J. J. Cell Biol. (1995)
- Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity. Li, M., Ren, S., Tilli, M.T., Flaws, J.A., Lubet, R., Grubbs, C.J., Furth, P.A. Oncogene (2003)
- Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice. Li, S., Rosen, J.M. Mol. Cell. Biol. (1995)
- Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. Schoenenberger, C.A., Andres, A.C., Groner, B., van der Valk, M., LeMeur, M., Gerlinger, P. EMBO J. (1988)
- Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata. Lee, E.Y., Parry, G., Bissell, M.J. J. Cell Biol. (1984)
- Cloning, transcription and chromosomal localization of the porcine whey acidic protein gene and its expression in HC11 cell line. Rival, S., Attal, J., Delville-Giraud, C., Yerle, M., Laffont, P., Rogel-Gaillard, C., Houdebine, L. Gene (2001)
- Expression of whey acidic protein (WAP) genes in tissues other than the mammary gland in normal and transgenic mice expressing mWAP/hGH fusion gene. Wen, J., Kawamata, Y., Tojo, H., Tanaka, S., Tachi, C. Mol. Reprod. Dev. (1995)
- Inhibition of myc-dependent breast tumor formation in transgenic mice. Cui, W., Gusterson, B.A., Clark, A.J. Breast Cancer Res. Treat. (2002)
- Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Andres, A.C., Schönenberger, C.A., Groner, B., Hennighausen, L., LeMeur, M., Gerlinger, P. Proc. Natl. Acad. Sci. U.S.A. (1987)
- SV40 T-antigen induces breast cancer formation with a high efficiency in lactating and virgin WAP-SV-T transgenic animals but with a low efficiency in ovariectomized animals. Santarelli, R., Tzeng, Y.J., Zimmermann, C., Guhl, E., Graessmann, A. Oncogene (1996)
- Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids. Schoenenberger, C.A., Zuk, A., Groner, B., Jones, W., Andres, A.C. Dev. Biol. (1990)
- Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. McAlhany, S.J., Ressler, S.J., Larsen, M., Tuxhorn, J.A., Yang, F., Dang, T.D., Rowley, D.R. Cancer Res. (2003)
- Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation. Burdon, T., Sankaran, L., Wall, R.J., Spencer, M., Hennighausen, L. J. Biol. Chem. (1991)
- Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution. Bagheri-Yarmand, R., Vadlamudi, R.K., Kumar, R. J. Biol. Chem. (2003)
- Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation. Walton, K.D., Wagner, K.U., Rucker, E.B., Shillingford, J.M., Miyoshi, K., Hennighausen, L. Mech. Dev. (2001)
- Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis. Raafat, A., Zoltan-Jones, A., Strizzi, L., Bargo, S., Kimura, K., Salomon, D., Callahan, R. Oncogene (2007)
- Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Liu, X., Robinson, G.W., Gouilleux, F., Groner, B., Hennighausen, L. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Studies of the regulation of the mouse carboxyl ester lipase gene in mammary gland. Kannius-Janson, M., Lidberg, U., Hultén, K., Gritli-Linde, A., Bjursell, G., Nilsson, J. Biochem. J. (1998)
- Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. Sympson, C.J., Talhouk, R.S., Alexander, C.M., Chin, J.R., Clift, S.M., Bissell, M.J., Werb, Z. J. Cell Biol. (1994)
- Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription. Mukhopadhyay, S.S., Wyszomierski, S.L., Gronostajski, R.M., Rosen, J.M. Mol. Cell. Biol. (2001)
- Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice. Yarus, S., Rosen, J.M., Cole, A.M., Diamond, G. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation. Brandt, R., Eisenbrandt, R., Leenders, F., Zschiesche, W., Binas, B., Juergensen, C., Theuring, F. Oncogene (2000)
- Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Kordon, E.C., McKnight, R.A., Jhappan, C., Hennighausen, L., Merlino, G., Smith, G.H. Dev. Biol. (1995)