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Igf2bp1  -  insulin-like growth factor 2 mRNA binding...

Rattus norvegicus

Synonyms: B-actin zipcode-binding protein 1, IGF-II mRNA-binding protein 1, IGF2 mRNA-binding protein 1, IMP-1, Imp1, ...
 
 
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Disease relevance of Igf2bp1

 

High impact information on Igf2bp1

  • Reexpression of ZBP1 in metastatic cells with otherwise low levels of ZBP1 reestablished normal patterns of beta-actin mRNA targeting and suppressed chemotaxis and invasion in primary tumors [1].
  • These cis-acting elements bind the trans-acting factors fibroblast ZBP-1 and hnRNP A2, respectively [2].
  • Here, we show that ZBP1 is required for the localization of beta-actin mRNA to dendrites [3].
  • Previous studies have shown that beta-actin mRNA localization to the leading edge of fibroblasts or the growth cones of developing neurites involved a specific interaction between a zipcode sequence in the 3' untranslated region and the mRNA-binding protein zipcode-binding protein-1 (ZBP1) [3].
  • The activity-dependent trafficking of ZBP1 and its dynamic movements within dendritic spines provide new evidence to implicate RNA binding proteins as regulators of mRNA transport to activated synapses in response to synaptic activity [4].
 

Biological context of Igf2bp1

 

Anatomical context of Igf2bp1

 

Co-localisations of Igf2bp1

  • A population of ZBP1 granules colocalized with beta-actin mRNA, and their spatial association in dendrites was increased by KCl depolarization [4].
 

Analytical, diagnostic and therapeutic context of Igf2bp1

  • With the use of immunofluorescence, image deconvolution, and three-dimensional reconstruction, ZBP1 was localized in the form of granules that were distributed in dendrites, spines, and subsynaptic sites [4].
  • Live cell imaging of single cells before and after perfusion of KCl revealed the rapid and directed efflux of ZBP1 granules from the cell body into dendrites in a proximo-distal gradient [4].

References

  1. Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Wang, W., Goswami, S., Lapidus, K., Wells, A.L., Wyckoff, J.B., Sahai, E., Singer, R.H., Segall, J.E., Condeelis, J.S. Cancer Res. (2004) [Pubmed]
  2. RNA trafficking and stabilization elements associate with multiple brain proteins. Snee, M., Kidd, G.J., Munro, T.P., Smith, R. J. Cell. Sci. (2002) [Pubmed]
  3. Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses. Eom, T., Antar, L.N., Singer, R.H., Bassell, G.J. J. Neurosci. (2003) [Pubmed]
  4. Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons. Tiruchinapalli, D.M., Oleynikov, Y., Kelic, S., Shenoy, S.M., Hartley, A., Stanton, P.K., Singer, R.H., Bassell, G.J. J. Neurosci. (2003) [Pubmed]
  5. Identification of xanthine dehydrogenase/xanthine oxidase as a rat Paneth cell zinc-binding protein. Morita, Y., Sawada, M., Seno, H., Takaishi, S., Fukuzawa, H., Miyake, N., Hiai, H., Chiba, T. Biochim. Biophys. Acta (2001) [Pubmed]
 
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