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Gene Review:

AF251705 - cDNA sequence AF251705

Mus musculus

Synonyms: CLM, CLM4, CMRF35-like molecule, Cd300c, Cd300d, ...

Luo, K. et al., Nakahashi, C. et al., Yotsumoto, K. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Cd300d

Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation [1].
The FcRgamma chain may provide cooperation with and/or compensation for DAP12 in MAIR-II-mediated inflammatory responses by peritoneal macrophages [2].
The lysine residue in the transmembrane region of MAIR-II was involved in the association with FcRgamma chain as well as DAP12 [2].
DIgR1, a novel membrane receptor of the immunoglobulin gene superfamily, is preferentially expressed by antigen-presenting cells [3].
The preferential expression of DIgR1 mRNA is observed in the known antigen-presenting cells (APC) including DC, monocytes/macrophages, and B lymphocytes [3].

Anatomical context of Cd300d

A novel membrane receptor of immunoglobulin gene superfamily (IgSF) has been identified from mouse dendritic cells (DC) and designated as DC-derived Ig-like receptor 1 (DIgR1) [3].
A 40 kDa of protein in NIH/3T3 cells transfected with the DIgR1 cDNA was detected by Western blot analysis using anti-DIgR1 polyclonal antibodies [3].

References

Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. Yotsumoto, K., Okoshi, Y., Shibuya, K., Yamazaki, S., Tahara-Hanaoka, S., Honda, S., Osawa, M., Kuroiwa, A., Matsuda, Y., Tenen, D.G., Iwama, A., Nakauchi, H., Shibuya, A. J. Exp. Med. (2003) [Pubmed]
Dual Assemblies of an Activating Immune Receptor, MAIR-II, with ITAM-Bearing Adapters DAP12 and FcR{gamma} Chain on Peritoneal Macrophages. Nakahashi, C., Tahara-Hanaoka, S., Totsuka, N., Okoshi, Y., Takai, T., Ohkohchi, N., Honda, S., Shibuya, K., Shibuya, A. J. Immunol. (2007) [Pubmed]
DIgR1, a novel membrane receptor of the immunoglobulin gene superfamily, is preferentially expressed by antigen-presenting cells. Luo, K., Zhang, W., Sui, L., Li, N., Zhang, M., Ma, X., Zhang, L., Cao, X. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CD300C	Bos taurus
LOC526163	Bos taurus
CD300C	Canis lupus familiaris
CD300C	Homo sapiens
CD300C	Macaca mulatta
Cd300c	Mus musculus
CD300C	Pan troglodytes
LOC100909671	Rattus norvegicus
RGD1561778	Rattus norvegicus
Igsf7	Rattus norvegicus
RGD1559482	Rattus norvegicus
RGD1562667	Rattus norvegicus
Cd300c	Rattus norvegicus
RGD1559458	Rattus norvegicus

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