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Gene Review

CD300C  -  CD300c molecule

Homo sapiens

Synonyms: CD300 antigen-like family member C, CLM-6, CMRF-35, CMRF-35A, CMRF35, ...
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Disease relevance of CD300C

  • The evaluation of insulin response after Dex may thus allow differentiation of the subset of LIR that run an increased risk of non-insulin-dependent diabetes mellitus [1].
  • The demonstrated higher baseline levels of SP-LIR and beta E-LIR as well as the increase after provocation in the BAL and NAL of allergic subjects but not in nonallergic controls support the hypothesis that these neuropeptides contribute to allergic reactions in airways of humans [2].
  • LIR representing prediabetes described muscle anomalies, which could represent prestages of the lesions observed in type-2 diabetes [3].
  • Both the release of ACTH and beta-endorphin LIR were stimulated by 0.1 microM lysine vasopressin (LVP) in all three adenoma cell cultures [4].

High impact information on CD300C

  • ACTH-LIR was also detected in seven different cell lines derived from patients with lymphoid and myeloid malignancies, two of them JM and U937 showing the highest values 135 and 108 pg/10(7) cells, respectively [5].
  • We conclude that PBMC produce ACTH-LIR which may act as a paracrine immunomodulator in a similar way to lymphokines and/or may signal the adrenal gland to secrete glucocorticoids [5].
  • Dex increased basal glycemia more in LIR because only in LIR was glucose production increased [1].
  • After Dex, in three LIR but in no HIR, a diabetic OGTT was observed [1].
  • In this study, we describe the characterization of human CD300b, a novel member of the CMRF-35/immune receptor expressed by myeloid cell (IREM) multigene family of immune receptors [6].

Biological context of CD300C


Anatomical context of CD300C

  • The CMRF-35 monoclonal antibody recognizes an epitope found on at least two cell surface molecules, differentially expressed by many leukocytes [8].
  • Transcripts encoding the CMRF35 protein were detected in early monocytic cell lines, in peripheral blood T cells and in some B lymphoblastoid cell lines, confirming the results of immunocytological staining [9].
  • However, the level of CMRF35 expression on peripheral blood T cells was shown to decrease in response to mitogenic stimulation [9].
  • The CMRF35 monoclonal antibody recognizes a cell membrane antigen present on the surface of monocytes, neutrophils, a proportion of peripheral blood T and B lymphocytes and lymphocytic cell lines [9].
  • We describe here the cloning and sequencing of a cDNA encoding the CMRF35 antigen by means of expression in COS cells and immunoselection with the CMRF35 monoclonal antibody [9].

Associations of CD300C with chemical compounds

  • A cDNA expressing the CMRF-35 epitope was isolated by expression cloning and this predicts for a type I cell surface glycoprotein belonging to the Ig superfamily [10].
  • Dex increased fasting glucose more in LIR (P less than 0.05) [1].
  • Dex significantly increased basal hepatic glucose production (turnover measured with [6-3H]glucose), hepatic total glucose output (turnover measured with [2-3H]glucose), and glucose cycling (hepatic total glucose output--hepatic glucose production) only in LIR [1].
  • Allergen provocation did not influence SP-LIR and beta E-LIR concentration in BAL and NAL in nonallergic controls [2].
  • The aqueous solution structures of the complexes were thoroughly characterized, the diamagnetic ones (La(3+) and Lu(3+)) by their COSY NMR spectra, and the paramagnetic complexes using a linear least-squares fitting of the (1)H LIS (lanthanide-induced shift) and LIR (lanthanide-induced relaxation) data with rhombic magnetic susceptibility tensors [11].

Other interactions of CD300C

  • This would further indicate that, like other ITIM/ITAM containing molecules, CMRF-35H/CMRF-35A will also play an important role in the immune response [8].
  • The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor [10].
  • IgSF13 shows significant homology to human CMRF35 and pIgR [12].
  • MDIR domains exhibit distant sequence similarity to mammalian CMRF-35-like molecules, polymeric immunoglobulin receptors, triggering receptors expressed on myeloid cells (TREMs), TREM-like transcripts, NKp44 and FcR homologs, as well as to sequences identified in several different vertebrate genomes [13].
  • Several of the differentially expressed genes are associated with immunologic functions (e.g., CMRF35 antigen, IL-8, HD protein) and implicate immune dysfunction in the pathophysiology of CFS [14].

Analytical, diagnostic and therapeutic context of CD300C

  • During OGTT, the LIR who were not able to counteract the effects of Dex by an appropriate enhancement in insulin secretion developed a decreased OGTT [1].
  • Substance P-like immunoreactivity (SP-LIR) and beta-endorphin-like immunoreactivity (beta E-LIR) were determined in bronchoalveolar lavage (BAL) and nasal lavage (NAL) fluids before and after allergen (grass pollen) provocation [2].
  • SP-LIR was found in nasal lavage specimens in concentrations between 2 and 10 fmol/ml and consisted of authentic SP and, to a less extent, SP-sulfoxide [15].


  1. The diabetogenic effects of glucocorticoids are more pronounced in low- than in high-insulin responders. Wajngot, A., Giacca, A., Grill, V., Vranic, M., Efendic, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Substance P and beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma. Nieber, K., Baumgarten, C.R., Rathsack, R., Furkert, J., Oehme, P., Kunkel, G. J. Allergy Clin. Immunol. (1992) [Pubmed]
  3. Muscle metabolism and quality (MQI) in prediabetic sedentary man. Karlsson, J., Rønneberg, R. Mol. Cell. Biochem. (1998) [Pubmed]
  4. ACTH and beta-endorphin secretion by three corticotrophic adenomas in culture. Effects of culture time, dexamethasone, vasopressin and synthetic corticotrophin releasing factor. Oosterom, R., Verleun, T., Uitterlinden, P., Hackeng, W.H., Burbach, J.P., Wiegant, V.M., Lamberts, S.W. Acta Endocrinol. (1984) [Pubmed]
  5. Expression of pro-opiomelanocortin gene and quantification of adrenocorticotropic hormone-like immunoreactivity in human normal peripheral mononuclear cells and lymphoid and myeloid malignancies. Buzzetti, R., McLoughlin, L., Lavender, P.M., Clark, A.J., Rees, L.H. J. Clin. Invest. (1989) [Pubmed]
  6. Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways. Martínez-Barriocanal, A., Sayós, J. J. Immunol. (2006) [Pubmed]
  7. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. Clark, G.J., Cooper, B., Fitzpatrick, S., Green, B.J., Hart, D.N. Tissue Antigens (2001) [Pubmed]
  8. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. Clark, G.J., Green, B.J., Hart, D.N. Tissue Antigens (2000) [Pubmed]
  9. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. Jackson, D.G., Hart, D.N., Starling, G., Bell, J.I. Eur. J. Immunol. (1992) [Pubmed]
  10. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. Green, B.J., Clark, G.J., Hart, D.N. Int. Immunol. (1998) [Pubmed]
  11. X-ray diffraction and (1)H NMR in solution: structural determination of lanthanide complexes of a Py(2)N(6)Ac(4) ligand. Valencia, L., Martinez, J., Macías, A., Bastida, R., Carvalho, R.A., Geraldes, C.F. Inorganic chemistry. (2002) [Pubmed]
  12. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. Sui, L., Li, N., Liu, Q., Zhang, W., Wan, T., Wang, B., Luo, K., Sun, H., Cao, X. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  13. Ancient divergence of a complex family of immune-type receptor genes. Cannon, J.P., Haire, R.N., Mueller, M.G., Litman, R.T., Eason, D.D., Tinnemore, D., Amemiya, C.T., Ota, T., Litman, G.W. Immunogenetics (2006) [Pubmed]
  14. Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndrome. Vernon, S.D., Unger, E.R., Dimulescu, I.M., Rajeevan, M., Reeves, W.C. Dis. Markers (2002) [Pubmed]
  15. Determination of substance P in human nasal lavage fluid. Schultz, K.D., Furkert, J., O'Connor, A., Böttcher, M., Schmidt, M., Baumgarten, C.R., Kunkel, G. Neuropeptides (1996) [Pubmed]
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