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Gene Review

Fgf17  -  fibroblast growth factor 17

Mus musculus

Synonyms: FGF-17, Fibroblast growth factor 17
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Disease relevance of Fgf17

  • As expected, recombinant rat FGF-17 was efficiently secreted by High Five insect cells infected with recombinant baculovirus containing the cDNA indicating that FGF-17 is a secreted protein [1].

High impact information on Fgf17

  • Early patterning of the vertebrate midbrain and cerebellum is regulated by a mid/hindbrain organizer that produces three fibroblast growth factors (FGF8, FGF17 and FGF18) [2].
  • The consequence of this developmental defect is a progressive, dose-dependent loss of the most anterior lobe of the vermis in mice lacking Fgf17 and in mice lacking Fgf17 and one copy of Fgf8 [3].
  • In situ hybridization analysis showed that the genes encoding the signaling molecules FGF17 and BMP2 are specifically expressed in the VER [4].
  • Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures [3].
  • Disrupting the Fgf17 gene in the mouse decreased precursor cell proliferation in the medial cerebellar (vermis) anlage after E11 [3].

Biological context of Fgf17

  • Both Fgf8 and Fgf17 have a similar structure and a similar pattern of alternative splicing in the 5' coding region [5].
  • During midgestation embryogenesis, in situ hybridization analysis localized Fgf17 expression to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, the developing skeleton and in developing arteries [5].
  • FGF17 mRNA was expressed in ES cells differentiated to an early endodermal phenotype [6].
  • Here, comparative proteomics and comparative genomics analyses on FGF8, FGF17, and FGF18 orthologs were performed [6].

Anatomical context of Fgf17

  • Comparison to Fgf8 revealed a striking similarity in expression patterns, especially in the central nervous system (CNS), suggesting that both genes may be important for CNS development, although Fgf17 is expressed somewhat later than Fgf8 [5].
  • A lower level of signaling transduced by Fgf8a, Fgf17 and Fgf18 induce midbrain development [7].

Other interactions of Fgf17

  • Here, we report the expression from early streak stage to midgestation of two newly-identified murine genes, Fgf17 and Fgf18, that are most closely related to Fgf8 (63.7% and 56.8% identical, respectively, at the amino acid level) [8].

Analytical, diagnostic and therapeutic context of Fgf17

  • Using surface plasmon resonance (SPR), we also characterized the receptor-binding specificity of FGF8a and FGF8b, the "b" isoform of FGF17 (FGF17b), and FGF18 [9].
  • FGF17 was detected at low levels by array and moderate levels by RT-PCR [10].


  1. Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. Hoshikawa, M., Ohbayashi, N., Yonamine, A., Konishi, M., Ozaki, K., Fukui, S., Itoh, N. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  2. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Liu, A., Li, J.Y., Bromleigh, C., Lao, Z., Niswander, L.A., Joyner, A.L. Development (2003) [Pubmed]
  3. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Xu, J., Liu, Z., Ornitz, D.M. Development (2000) [Pubmed]
  4. Fate and function of the ventral ectodermal ridge during mouse tail development. Goldman, D.C., Martin, G.R., Tam, P.P. Development (2000) [Pubmed]
  5. Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Xu, J., Lawshe, A., MacArthur, C.A., Ornitz, D.M. Mech. Dev. (1999) [Pubmed]
  6. Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  7. How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development? Sato, T., Joyner, A.L., Nakamura, H. Dev. Growth Differ. (2004) [Pubmed]
  8. Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Maruoka, Y., Ohbayashi, N., Hoshikawa, M., Itoh, N., Hogan, B.L., Furuta, Y. Mech. Dev. (1998) [Pubmed]
  9. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Olsen, S.K., Li, J.Y., Bromleigh, C., Eliseenkova, A.V., Ibrahimi, O.A., Lao, Z., Zhang, F., Linhardt, R.J., Joyner, A.L., Mohammadi, M. Genes Dev. (2006) [Pubmed]
  10. FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. Zhong, W., Wang, Q.T., Sun, T., Wang, F., Liu, J., Leach, R., Johnson, A., Puscheck, E.E., Rappolee, D.A. Mol. Reprod. Dev. (2006) [Pubmed]
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