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Gene Review

Gbp2b  -  guanylate binding protein 2b

Mus musculus

Synonyms: GBP-1, GTP-binding protein 1, Gbp-1, Gbp1, Guanine nucleotide-binding protein 1, ...
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Disease relevance of Gbp1


Psychiatry related information on Gbp1


High impact information on Gbp1


Chemical compound and disease context of Gbp1


Biological context of Gbp1

  • An RNA species has been identified whose nucleotide sequence is closely related to the mRNA encoding the murine interferon (IFN)-induced guanylate-binding protein-1 (mGBP1) and an mRNA encoding an isoprenylated protein that is constitutively expressed in various organs in the rat [17].
  • Possible problems in cellular isoprenoid metabolism or prenyl transferase activity were investigated, but none that caused this defect was identified, implying that the poor labeling actually represented incomplete prenylation of mGBP1 itself [18].
  • Mutagenesis indicated that the last 18 residues of mGBP1 severely limited C20 incorporation but, surprisingly, were compatible with farnesyl modification [18].
  • Genomic fragments encompassing a portion of the mGBP-1 5' flanking region were inserted into vectors containing a luciferase reporter gene [19].
  • Interferon-induced guanylate-binding proteins: mapping of the murine Gbp-1 locus to chromosome 3 [20].

Anatomical context of Gbp1


Associations of Gbp1 with chemical compounds

  • One cDNA corresponds to the murine guanylate-binding protein gene Gbp-1/Mag-1 [25].
  • An aspartic acid residue (Asp79) highly conserved among guanine nucleotide-binding protein (G protein)-coupled receptors was mutated to asparagine; in cells transfected with the mutant alpha 2-receptor, agonists inhibited adenylyl cyclase and calcium currents but did not increase potassium currents [26].
  • The apparent mechanism of action of L651582 is via inhibition of the receptor-mediated stimulation of effector enzymes utilizing guanine nucleotide-binding protein signal transduction, which thus makes L651582 a novel anticancer agent [27].
  • In summary, our data provide evidence that regulation of PKC-alpha by 12(S)-HETE and 13(S)-HODE may be through a guanine nucleotide-binding protein-linked receptor-mediated hydrolysis of inositol phospholipids [28].
  • The physiological action of histamine has been shown to be mediated via a guanine nucleotide-binding protein linked to adenylate cyclase activation and cellular cAMP generation [29].

Physical interactions of Gbp1


Regulatory relationships of Gbp1


Other interactions of Gbp1


Analytical, diagnostic and therapeutic context of Gbp1


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  2. Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein. Prezeau, L., Manzoni, O., Homburger, V., Sladeczek, F., Curry, K., Bockaert, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells. Cruciani, R.A., Dvorkin, B., Morris, S.A., Crain, S.M., Makman, M.H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Growth rate dependence of differential incorporation of a guanosine triphosphate photoaffinity probe into the alpha subunit of a guanine nucleotide binding protein, Gs, from metastatic variants of B16 melanoma cells. Lange-Carter, C.A., Droms, K.A., Lester, B.R., Malkinson, A.M. Cancer Res. (1989) [Pubmed]
  5. Properties of beta-adrenergic receptors of cultured mammalian cells. Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells. Abramson, S.N., Molinoff, P.B. J. Biol. Chem. (1985) [Pubmed]
  6. Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes. Kitanaka, J., Wang, X.B., Kitanaka, N., Hembree, C.M., Uhl, G.R. DNA Seq. (2001) [Pubmed]
  7. The GTP-binding protein, Go, regulates neuronal calcium channels. Hescheler, J., Rosenthal, W., Trautwein, W., Schultz, G. Nature (1987) [Pubmed]
  8. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Hirsch, E., Katanaev, V.L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F., Wymann, M.P. Science (2000) [Pubmed]
  9. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Bohn, L.M., Lefkowitz, R.J., Gainetdinov, R.R., Peppel, K., Caron, M.G., Lin, F.T. Science (1999) [Pubmed]
  10. Nonselective and G betagamma-insensitive weaver K+ channels. Navarro, B., Kennedy, M.E., Velimirovíc, B., Bhat, D., Peterson, A.S., Clapham, D.E. Science (1996) [Pubmed]
  11. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Laudanna, C., Campbell, J.J., Butcher, E.C. Science (1996) [Pubmed]
  12. Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor. Seufferlein, T., Withers, D.J., Mann, D., Rozengurt, E. Mol. Biol. Cell (1996) [Pubmed]
  13. The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction. Lokeshwar, V.B., Bourguignon, L.Y. J. Biol. Chem. (1992) [Pubmed]
  14. Regulation of the catalytic component of adenylate cyclase. Potentiative interaction of stimulatory ligands and 2',5'-dideoxyadenosine. Florio, V.A., Ross, E.M. Mol. Pharmacol. (1983) [Pubmed]
  15. Angiotensin II effects on the cytosolic free Ca2+ concentration in N1E-115 neuroblastoma cells: kinetic properties of the Ca2+ transient measured in single fura-2-loaded cells. Monck, J.R., Williamson, R.E., Rogulja, I., Fluharty, S.J., Williamson, J.R. J. Neurochem. (1990) [Pubmed]
  16. Vasopressin rapidly stimulates protein kinase C in digitonin-permeabilized Swiss 3T3 cells: involvement of a pertussis toxin-insensitive guanine nucleotide binding protein. Erusalimsky, J.D., Rozengurt, E. J. Cell. Physiol. (1989) [Pubmed]
  17. Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family. Anderson, S.L., Carton, J.M., Zhang, X., Rubin, B.Y. J. Interferon Cytokine Res. (1999) [Pubmed]
  18. Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding protein. Stickney, J.T., Buss, J.E. Mol. Biol. Cell (2000) [Pubmed]
  19. Promoter analysis of an interferon-inducible gene associated with macrophage activation. Nicolet, C.M., Paulnock, D.M. J. Immunol. (1994) [Pubmed]
  20. Interferon-induced guanylate-binding proteins: mapping of the murine Gbp-1 locus to chromosome 3. Prochazka, M., Staeheli, P., Holmes, R.S., Haller, O. Virology (1985) [Pubmed]
  21. Effect of immunosuppression on gene expression in the HSV-1 latently infected mouse trigeminal ganglion. Higaki, S., Gebhardt, B.M., Lukiw, W.J., Thompson, H.W., Hill, J.M. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  22. The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. Costello, P.S., Cleverley, S.C., Galandrini, R., Henning, S.W., Cantrell, D.A. J. Exp. Med. (2000) [Pubmed]
  23. Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes. Ransnäs, L.A., Svoboda, P., Jasper, J.R., Insel, P.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  24. Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Berghard, A., Buck, L.B., Liman, E.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  25. Interleukin-10 gene transfer activates interferon-gamma and the interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors. Sun, H., Jackson, M.J., Kundu, N., Fulton, A.M. Int. J. Cancer (1999) [Pubmed]
  26. A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Surprenant, A., Horstman, D.A., Akbarali, H., Limbird, L.E. Science (1992) [Pubmed]
  27. L651582: a novel antiproliferative and antimetastasis agent. Kohn, E.C., Liotta, L.A. J. Natl. Cancer Inst. (1990) [Pubmed]
  28. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Liu, B., Khan, W.A., Hannun, Y.A., Timar, J., Taylor, J.D., Lundy, S., Butovich, I., Honn, K.V. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  29. Molecular cloning of a gene encoding the histamine H2 receptor. Gantz, I., Schäffer, M., DelValle, J., Logsdon, C., Campbell, V., Uhler, M., Yamada, T. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  30. Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Maroteaux, L., Saudou, F., Amlaiky, N., Boschert, U., Plassat, J.L., Hen, R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  31. Cannabinoid ligand-receptor signaling in the mouse uterus. Das, S.K., Paria, B.C., Chakraborty, I., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  32. The bombesin receptor is coupled to a guanine nucleotide-binding protein which is insensitive to pertussis and cholera toxins. Fischer, J.B., Schonbrunn, A. J. Biol. Chem. (1988) [Pubmed]
  33. The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by the use of antisense RNA inhibition and immunoblocking of the stimulatory guanine-nucleotide-binding protein. Paulssen, R.H., Paulssen, E.J., Gautvik, K.M., Gordeladze, J.O. Eur. J. Biochem. (1992) [Pubmed]
  34. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. de Buhr, M.F., Mähler, M., Geffers, R., Hansen, W., Westendorf, A.M., Lauber, J., Buer, J., Schlegelberger, B., Hedrich, H.J., Bleich, A. Physiol. Genomics (2006) [Pubmed]
  35. Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go. Strathmann, M., Wilkie, T.M., Simon, M.I. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  36. Expression of a G-protein beta subunit-related gene during lymphocyte activation. Shan, X., Luo, H., Houle, B., Wu, J. Int. Immunol. (1994) [Pubmed]
  37. Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems. Worley, P.F., Baraban, J.M., Van Dop, C., Neer, E.J., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  38. Effect of chronic ethanol treatment of Ca2+-inhibited adenylyl cyclase in mouse striatum. Ikeda, H., Hatta, S., Ozawa, H., Ohshika, H., Saito, T. Alcohol. Clin. Exp. Res. (1999) [Pubmed]
  39. Inositol 1,4,5-trisphosphate mediates adrenaline activation of K+ conductance in mouse peritoneal macrophages. Hara, N., Ichinose, M., Sawada, M., Maeno, T. Pflugers Arch. (1993) [Pubmed]
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