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Chemical Compound Review

AGN-PC-006SMH     3,7,11,15- tetramethylhexadeca- 2,6,10,14...

Synonyms: AG-E-70872, CTK2H7279, CTK4F2798, AC1L22RD, 7614-21-3, ...
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Disease relevance of C09094


High impact information on C09094


Chemical compound and disease context of C09094


Biological context of C09094


Anatomical context of C09094


Associations of C09094 with other chemical compounds


Gene context of C09094


  1. Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis. Montero, M.T., Matilla, J., Gómez-Mampaso, E., Lasunción, M.A. J. Immunol. (2004) [Pubmed]
  2. Biphasic effects of geranylgeraniol, teprenone, and phytol on the growth of Staphylococcus aureus. Inoue, Y., Hada, T., Shiraishi, A., Hirose, K., Hamashima, H., Kobayashi, S. Antimicrob. Agents Chemother. (2005) [Pubmed]
  3. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. Crick, D.C., Andres, D.A., Danesi, R., Macchia, M., Waechter, C.J. J. Neurochem. (1998) [Pubmed]
  4. Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis. Halasy-Nagy, J.M., Rodan, G.A., Reszka, A.A. Bone (2001) [Pubmed]
  5. Terminal steps of bacteriochlorophyll a phytol formation in purple photosynthetic bacteria. Shioi, Y., Sasa, T. J. Bacteriol. (1984) [Pubmed]
  6. Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Kotti, T.J., Ramirez, D.M., Pfeiffer, B.E., Huber, K.M., Russell, D.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Fisher, J.E., Rogers, M.J., Halasy, J.M., Luckman, S.P., Hughes, D.E., Masarachia, P.J., Wesolowski, G., Russell, R.G., Rodan, G.A., Reszka, A.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway. Laezza, C., Di Marzo, V., Bifulco, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s). Liu, L., Moesner, P., Kovach, N.L., Bailey, R., Hamilton, A.D., Sebti, S.M., Harlan, J.M. J. Biol. Chem. (1999) [Pubmed]
  10. Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis. Evdokiou, A., Labrinidis, A., Bouralexis, S., Hay, S., Findlay, D.M. Bone (2003) [Pubmed]
  11. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. McGuire, T.F., Qian, Y., Vogt, A., Hamilton, A.D., Sebti, S.M. J. Biol. Chem. (1996) [Pubmed]
  12. Isoprenylation of plant proteins in vivo. Isoprenylated proteins are abundant in the mitochondria and nuclei of spinach. Shipton, C.A., Parmryd, I., Swiezewska, E., Andersson, B., Dallner, G. J. Biol. Chem. (1995) [Pubmed]
  13. Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells. Masuda, Y., Yoda, M., Ohizumi, H., Aiuchi, T., Watabe, M., Nakajo, S., Nakaya, K. Int. J. Cancer (1997) [Pubmed]
  14. Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbs. Shidoji, Y., Ogawa, H. J. Lipid Res. (2004) [Pubmed]
  15. Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells. Roelofs, A.J., Hulley, P.A., Meijer, A., Ebetino, F.H., Russell, R.G., Shipman, C.M. Int. J. Cancer (2006) [Pubmed]
  16. Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation. Fernández-Hernando, C., Suárez, Y., Lasunción, M.A. Mol. Cell. Neurosci. (2005) [Pubmed]
  17. Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis. Colli, S., Eligini, S., Lalli, M., Camera, M., Paoletti, R., Tremoli, E. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  18. Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes. Funari, S.S., Prades, J., Escribá, P.V., Barceló, F. Mol. Membr. Biol. (2005) [Pubmed]
  19. Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. Theriault, A., Chao, J.T., Gapor, A., Chao, J.T., Gapor, A. Atherosclerosis (2002) [Pubmed]
  20. Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid. Yaguchi, M., Miyazawa, K., Katagiri, T., Nishimaki, J., Kizaki, M., Tohyama, K., Toyama, K. Leukemia (1997) [Pubmed]
  21. Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. Neville-Webbe, H.L., Rostami-Hodjegan, A., Evans, C.A., Coleman, R.E., Holen, I. Int. J. Cancer (2005) [Pubmed]
  22. The mechanism of the attachment of esterifying alcohol in bacteriochlorophyll a biosynthesis. Akhtar, M., Ajaz, A.A., Corina, D.L. Biochem. J. (1984) [Pubmed]
  23. The inhibitory effect of alendronate, a nitrogen-containing bisphosphonate on the PI3K-Akt-NFkappaB pathway in osteosarcoma cells. Inoue, R., Matsuki, N.A., Jing, G., Kanematsu, T., Abe, K., Hirata, M. Br. J. Pharmacol. (2005) [Pubmed]
  24. The mechanism of geranylgeraniol-induced apoptosis involves activation, by a caspase-3-like protease, of a c-jun N-terminal kinase signaling cascade and differs from mechanisms of apoptosis induced by conventional chemotherapeutic drugs. Masuda, Y., Nakaya, M., Aiuchi, T., Hashimoto, S., Nakajo, S., Nakaya, K. Leuk. Res. (2000) [Pubmed]
  25. Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages. Vestal, D.J., Buss, J.E., McKercher, S.R., Jenkins, N.A., Copeland, N.G., Kelner, G.S., Asundi, V.K., Maki, R.A. J. Interferon Cytokine Res. (1998) [Pubmed]
  26. Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). Woo, J.T., Nakagawa, H., Krecic, A.M., Nagai, K., Hamilton, A.D., Sebti, S.M., Stern, P.H. Biochem. Pharmacol. (2005) [Pubmed]
  27. Cytotoxic activity of polyprenylalcohols and vitamin K2 derivatives. Ishihara, M., Takayama, F., Toguchi, M., Nakano, K., Yasumoto, E., Nakayachi, T., Satoh, K., Sakagami, H. Anticancer Res. (2000) [Pubmed]
  28. Farnesol inhibits L-type Ca2+ channels in vascular smooth muscle cells. Roullet, J.B., Luft, U.C., Xue, H., Chapman, J., Bychkov, R., Roullet, C.M., Luft, F.C., Haller, H., McCarron, D.A. J. Biol. Chem. (1997) [Pubmed]
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