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Gene Review

CSNK1E  -  casein kinase 1, epsilon

Homo sapiens

Synonyms: CKI-epsilon, CKIE, CKIe, CKIepsilon, Casein kinase I isoform epsilon, ...
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High impact information on CSNK1E


Biological context of CSNK1E


Anatomical context of CSNK1E


Associations of CSNK1E with chemical compounds


Physical interactions of CSNK1E

  • We have identified casein kinase I epsilon (CKI epsilon) as a binding partner for the C-terminal cytoplasmic domain of occludin by yeast two-hybrid screening [4].

Other interactions of CSNK1E


  1. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. Hino, S., Michiue, T., Asashima, M., Kikuchi, A. J. Biol. Chem. (2003) [Pubmed]
  2. Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis. Cegielska, A., Gietzen, K.F., Rivers, A., Virshup, D.M. J. Biol. Chem. (1998) [Pubmed]
  3. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. Fish, K.J., Cegielska, A., Getman, M.E., Landes, G.M., Virshup, D.M. J. Biol. Chem. (1995) [Pubmed]
  4. Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin. McKenzie, J.A., Riento, K., Ridley, A.J. FEBS Lett. (2006) [Pubmed]
  5. Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine. Veenstra-VanderWeele, J., Qaadir, A., Palmer, A.A., Cook, E.H., de Wit, H. Neuropsychopharmacology (2006) [Pubmed]
  6. Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. Keesler, G.A., Camacho, F., Guo, Y., Virshup, D., Mondadori, C., Yao, Z. Neuroreport (2000) [Pubmed]
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