Gene Review:
FRAT1 - frequently rearranged in advanced T-cell...
Homo sapiens
Synonyms:
FRAT-1, Frequently rearranged in advanced T-cell lymphomas 1, Proto-oncogene FRAT1
- Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. Freemantle, S.J., Portland, H.B., Ewings, K., Dmitrovsky, F., DiPetrillo, K., Spinella, M.J., Dmitrovsky, E. Gene (2002)
- Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. Saitoh, T., Mine, T., Katoh, M. Int. J. Oncol. (2002)
- Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. Dajani, R., Fraser, E., Roe, S.M., Yeo, M., Good, V.M., Thompson, V., Dale, T.C., Pearl, L.H. EMBO J. (2003)
- Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. Li, L., Yuan, H., Weaver, C.D., Mao, J., Farr, G.H., Sussman, D.J., Jonkers, J., Kimelman, D., Wu, D. EMBO J. (1999)
- Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. Hino, S., Michiue, T., Asashima, M., Kikuchi, A. J. Biol. Chem. (2003)
- FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. Saitoh, T., Katoh, M. Int. J. Oncol. (2001)
- FRAT1 peptide decreases Abeta production in swAPP(751) cells. Li, B., Ryder, J., Su, Y., Zhou, Y., Liu, F., Ni, B. FEBS Lett. (2003)
- Proteomic analysis of the proliferative and secretory phases of the human endometrium: protein identification and differential protein expression. DeSouza, L., Diehl, G., Yang, E.C., Guo, J., Rodrigues, M.J., Romaschin, A.D., Colgan, T.J., Siu, K.W. Proteomics (2005)
- Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. Saitoh, T., Moriwaki, J., Koike, J., Takagi, A., Miwa, T., Shiokawa, K., Katoh, M. Biochem. Biophys. Res. Commun. (2001)
- A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. Thomas, G.M., Frame, S., Goedert, M., Nathke, I., Polakis, P., Cohen, P. FEBS Lett. (1999)
- FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. Hagen, T., Cross, D.A., Culbert, A.A., West, A., Frame, S., Morrice, N., Reith, A.D. J. Biol. Chem. (2006)
- Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth. Mazor, M., Kawano, Y., Zhu, H., Waxman, J., Kypta, R.M. Oncogene (2004)
- Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. Wang, Y., Hewitt, S.M., Liu, S., Zhou, X., Zhu, H., Zhou, C., Zhang, G., Quan, L., Bai, J., Xu, N. Br. J. Cancer (2006)