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Gene Review

circ  -  potentially envelope-associated

Bovine herpesvirus 1

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Disease relevance of circ


High impact information on circ


Analytical, diagnostic and therapeutic context of circ

  • It was noted that the circ gene could be deleted from the BHV-1 genome without impairing virus replication in cell culture [4].
  • Using a rabbit antiserum raised against a synthetic oligopeptide representing the carboxy terminus of the predicted circ polypeptide for Western blot (immunoblot) analyses and immunofluorescence assays, we identified a 34-kDa virion-associated protein which accumulated in the cytoplasm of infected cells [4].


  1. Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1. Schwyzer, M., Styger, D., Vogt, B., Lowery, D.E., Simard, C., LaBoissière, S., Misra, V., Vlĉek, C., Paĉes, V. Vet. Microbiol. (1996) [Pubmed]
  2. Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: the circ gene. Fraefel, C., Wirth, U.V., Vogt, B., Schwyzer, M. J. Virol. (1993) [Pubmed]
  3. Identification and characterization of BICP27, an early protein of bovine herpesvirus 1 which may stimulate mRNA 3' processing. Singh, M., Fraefel, C., Bello, L.J., Lawrence, W.C., Schwyzer, M. J. Gen. Virol. (1996) [Pubmed]
  4. Identification of the bovine herpesvirus 1 circ protein, a myristylated and virion-associated polypeptide which is not essential for virus replication in cell culture. Fraefel, C., Ackermann, M., Schwyzer, M. J. Virol. (1994) [Pubmed]
  5. Transduction of Vero cells and bovine monocytes with a herpes simplex virus-1 based amplicon carrying the gene for the bovine herpesvirus-1 Circ protein. Schwyzer, M., Fischer-Bracher, C., Fraefel, C., Bächi, T., Nuñez, R., Engels, M., Ackermann, M. Vet. Microbiol. (2002) [Pubmed]
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