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Gene Review:

CYLC1 - cylicin, basic protein of sperm head...

Homo sapiens

Synonyms: CYL, CYL1, Cylicin I, Cylicin-1, Multiple-band polypeptide I

Hess, H. et al., Boyer, M.J. et al., Hess, H. et al., Levine, H.B. et al., Fouquet, J.P. et al.

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Disease relevance of CYLC1

A yeast phase histoplasmin, designated CYL, was studied in 156 humans living in areas of the United States endemic for histoplasmosis, coccidioidomycosis, or both fungal entities [1].

High impact information on CYLC1

By Northern blot analysis we have identified the 2.4-kb cylicin I mRNA only in testis [2].
Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton [2].
The unusual cytoskeletal protein cylicin is compared with other proteins and its possible architectural role during spermiogenesis is discussed [2].
The possible existence of a larger cylicin multigene family and its contribution to the cytoskeleton and the morphogenesis of the sperm head are discussed [3].
In the head, a dense perinuclear layer is made of basic proteins (calicin, cylicin, etc) associated with calmodulin and actin remnants [4].

Anatomical context of CYLC1

As with cylicin I mRNA, the 2.6-kb mRNA has also been shown to be specifically expressed in testis [3].

Analytical, diagnostic and therapeutic context of CYLC1

The use of Histolyn CYL in an enzyme immunoassay to detect Histoplasma capsulatum antibodies [5].
Minimal cross reactivity was evidenced when Histolyn CYL was used in the ELISA to detect anti-Coccidioides immitis antibody in sera from infected animals and humans [5].

References

Histoplasmin-CYL, a yeast phase reagent in skin test studies with humans. Levine, H.B., Scalarone, G.M., Campbell, G.D., Graybill, J.R., Kelly, P.C., Chaparas, S.D. Am. Rev. Respir. Dis. (1979) [Pubmed]
Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton. Hess, H., Heid, H., Franke, W.W. J. Cell Biol. (1993) [Pubmed]
The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. Hess, H., Heid, H., Zimbelmann, R., Franke, W.W. Exp. Cell Res. (1995) [Pubmed]
The cytoskeleton of mammalian spermatozoa. Fouquet, J.P., Kann, M.L. Biol. Cell (1994) [Pubmed]
The use of Histolyn CYL in an enzyme immunoassay to detect Histoplasma capsulatum antibodies. Boyer, M.J., Scalarone, G.M. Sabouraudia. (1983) [Pubmed]

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CYLC1	Bos taurus
CYLC1	Canis lupus familiaris
LOC713478	Macaca mulatta
CYLC1	Pan troglodytes

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