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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hrsp12  -  heat-responsive protein 12

Mus musculus

Synonyms: HR12, HRP12, Heat-responsive protein 12, Hrp12, Ribonuclease UK114
 
 
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Disease relevance of Hrsp12

  • Significant similarities with mouse HR12 protein were also observed, whereas a lower degree of similarity was found with a family of heat-responsive proteins named YJGF and YABJ from Haemophilus influenzae and Bacillus subtilis, respectively [1].
 

High impact information on Hrsp12

  • We have used the selective farnesylation inhibitor HR12 [cysteine-N(methyl)valine-N(cyclohexyl) glycine-methionine-O-methyl-ester] to study the role of oncogenic Ras in cytoskeletal reorganization in Ha-ras(V12)-transformed Rat1 cells (Rat1/ras) [2].
  • Furthermore, HR12 induced assembly of adherens junctions and dramatically elevated the level of the junctional components, cadherin and beta-catenin [2].
  • HR12 was unable to restore the nontransformed phenotype in cells expressing farnesylation-independent, myristylated Ras [2].
  • Application of HR12 resulted in complete restoration of the cytoskeleton and associated cell adhesions disrupted by oncogenic Ras [2].
  • This prompted us to investigate the heat shock response of Hrp12 [3].
 

Biological context of Hrsp12

  • The cell permeable methyl ester derivative of HR-11, HR-12, inhibits Ras farnesylation in intact cells with an IC50 of 10 microM and with no detectable inhibition of Rap1A/K-rev geranyl-geranylation [4].
 

Associations of Hrsp12 with chemical compounds

  • Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) purification, followed by sequencing of an in situ cyanogen bromide digest of membrane bound Hrp12, yielded an internal 20-amino acid polypeptide [3].
 

Other interactions of Hrsp12

References

  1. Molecular and functional properties of a calpain activator protein specific for mu-isoforms. Melloni, E., Michetti, M., Salamino, F., Pontremoli, S. J. Biol. Chem. (1998) [Pubmed]
  2. Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway. Reuveni, H., Geiger, T., Geiger, B., Levitzki, A. J. Cell Biol. (2000) [Pubmed]
  3. Hrp12, a novel heat-responsive, tissue-specific, phosphorylated protein isolated from mouse liver. Samuel, S.J., Tzung, S.P., Cohen, S.A. Hepatology (1997) [Pubmed]
  4. Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors. Reuveni, H., Gitler, A., Poradosu, E., Gilon, C., Levitzki, A. Bioorg. Med. Chem. (1997) [Pubmed]
  5. Genes involved in nonpermissive temperature-induced cell differentiation in Sertoli TTE3 cells bearing temperature-sensitive simian virus 40 large T-antigen. Tabuchi, Y., Kondo, T., Suzuki, Y., Obinata, M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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