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Gene Review

Irg1  -  immunoresponsive gene 1

Mus musculus

Synonyms: AI323667, Aconitate decarboxylase, CAD, Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, ...
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Disease relevance of Irg1


High impact information on Irg1

  • The inhibitor also blocked induction by LIF of several LIF-regulated genes in the LE including Irg1, which has been shown previously to be essential for implantation [2].
  • Administration of CCR9 and/or Irg1 small interfering RNA alters the frequency and functional profiles of neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(-) microglia in vivo [3].
  • In adult mice Irg1 expression was limited to the uterine luminal epithelium where it is expressed only during pregnancy with a peak coinciding with implantation [4].
  • Irg1 mRNA expression is regulated synergistically by P4 and estradiol (E2) but not by E2 alone [4].
  • In macrophages Irg1 is induced by lipopolysaccharide through a protein kinase C (PKC)-regulated pathway [4].

Biological context of Irg1

  • This resulted in the identification of one novel P4-regulated gene that had been previously found in lipopolysaccharide-stimulated macrophages and called immune response gene-1 (Irg1) and which is the mammalian ortholog of the bacterial gene encoding methylcitrate dehydratase [4].
  • This intervention was also accompanied by impairment in embryo implantation, indicating that the phenotype is linked to the suppression of Irg1 mRNA [5].

Anatomical context of Irg1


Associations of Irg1 with chemical compounds

  • These results suggest that the PKC pathway plays an important role in modulating steroid hormone responsiveness in the uterine luminal epithelium during the implantation window and that Irg1 will be an important marker of this window and may play an important role in implantation [4].
  • We reported that the mRNA corresponding to the immune-responsive gene 1 (Irg1), a previously described lipopolysaccharide-inducible gene, is one of the several mRNAs that are markedly down-regulated by RU486 in the preimplantation uterus [5].

Other interactions of Irg1


  1. Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors. Yun, C.O., Nolan, K.F., Beecham, E.J., Reisfeld, R.A., Junghans, R.P. Neoplasia (2000) [Pubmed]
  2. Inhibition of Stat3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Catalano, R.D., Johnson, M.H., Campbell, E.A., Charnock-Jones, D.S., Smith, S.K., Sharkey, A.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Different Neurotropic Pathogens Elicit Neurotoxic CCR9- or Neurosupportive CXCR3-Expressing Microglia. Li, H., Gang, Z., Yuling, H., Luokun, X., Jie, X., Hao, L., Li, W., Chunsong, H., Junyan, L., Mingshen, J., Youxin, J., Feili, G., Boquan, J., Jinquan, T. J. Immunol. (2006) [Pubmed]
  4. Progesterone regulation of the mammalian ortholog of methylcitrate dehydratase (immune response gene 1) in the uterine epithelium during implantation through the protein kinase C pathway. Chen, B., Zhang, D., Pollard, J.W. Mol. Endocrinol. (2003) [Pubmed]
  5. Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse. Cheon, Y.P., Xu, X., Bagchi, M.K., Bagchi, I.C. Endocrinology (2003) [Pubmed]
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