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Gene Review:

Itgb6 - integrin beta 6

Mus musculus

Synonyms: 2210409C20Rik, 4831415H04Rik, Integrin beta-6

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Disease relevance of Itgb6

Through a global analysis of pulmonary gene expression in the lungs of mice lacking this integrin (Itgb6 null mice) we have identified a marked induction of macrophage metalloelastase (Mmp12)--a metalloproteinase that preferentially degrades elastin and has been implicated in the chronic lung disease emphysema [1].
Furthermore, Itgb6-/- mice are also protected from ventilator-induced lung edema [2].
Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice [3].
We have previously shown that the integrin beta6 is neo-expressed in invasive oral squamous cell carcinoma (SCC) and is correlated with oral tumor progression [4].
These findings indicate that integrin beta6 signaling activates Fyn and thus promotes oral cancer progression [4].

High impact information on Itgb6

Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma [5].
We then compared the gene expression patterns in these mice with 129 mice carrying a null mutation in the epithelial-restricted integrin beta6 subunit (beta6(-/-)), which develop inflammation but are protected from pulmonary fibrosis [6].
Expression changes were compared with those identified by microarray analysis of interleukin-13-overexpressing and integrin-beta6-deficient mice, which both develop emphysema [7].
Induction of alpha-catenin, integrin alpha3, integrin beta6, and PDGF-B by 2,8-dihydroxyadenine crystals in cultured kidney epithelial cells [8].
The expression of three adhesion molecules (alpha-catenin, integrin alpha3, and integrin beta6) and platelet-derived growth factor B (PDGF-B) was elevated following exposure of NHK-C cells to DHA [8].

Other interactions of Itgb6

Characterization of integrin beta6 and thrombospondin-1 double-null mice [9].
We found that, upon ligation of the integrin beta6 with fibronectin, beta6 complexed with Fyn and activated it [4].

References

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Morris, D.G., Huang, X., Kaminski, N., Wang, Y., Shapiro, S.D., Dolganov, G., Glick, A., Sheppard, D. Nature (2003) [Pubmed]
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. Jenkins, R.G., Su, X., Su, G., Scotton, C.J., Camerer, E., Laurent, G.J., Davis, G.E., Chambers, R.C., Matthay, M.A., Sheppard, D. J. Clin. Invest. (2006) [Pubmed]
Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice. Huang, X., Wu, J., Zhu, W., Pytela, R., Sheppard, D. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
Alphavbeta6-Fyn signaling promotes oral cancer progression. Li, X., Yang, Y., Hu, Y., Dang, D., Regezi, J., Schmidt, B.L., Atakilit, A., Chen, B., Ellis, D., Ramos, D.M. J. Biol. Chem. (2003) [Pubmed]
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. Bates, R.C., Bellovin, D.I., Brown, C., Maynard, E., Wu, B., Kawakatsu, H., Sheppard, D., Oettgen, P., Mercurio, A.M. J. Clin. Invest. (2005) [Pubmed]
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Kaminski, N., Allard, J.D., Pittet, J.F., Zuo, F., Griffiths, M.J., Morris, D., Huang, X., Sheppard, D., Heller, R.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
A distinctive alveolar macrophage activation state induced by cigarette smoking. Woodruff, P.G., Koth, L.L., Yang, Y.H., Rodriguez, M.W., Favoreto, S., Dolganov, G.M., Paquet, A.C., Erle, D.J. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
Induction of alpha-catenin, integrin alpha3, integrin beta6, and PDGF-B by 2,8-dihydroxyadenine crystals in cultured kidney epithelial cells. Wang, L., Raikwar, N., Yang, M., Deng, L., McAteer, J.A., Stambrook, P.J., Sahota, A., Tischfield, J.A. Exp. Nephrol. (2002) [Pubmed]
Characterization of integrin beta6 and thrombospondin-1 double-null mice. Ludlow, A., Yee, K.O., Lipman, R., Bronson, R., Weinreb, P., Huang, X., Sheppard, D., Lawler, J. J. Cell. Mol. Med. (2005) [Pubmed]

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