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Gene Review

Itgb6  -  integrin beta 6

Mus musculus

Synonyms: 2210409C20Rik, 4831415H04Rik, Integrin beta-6
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Disease relevance of Itgb6


High impact information on Itgb6


Other interactions of Itgb6


  1. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Morris, D.G., Huang, X., Kaminski, N., Wang, Y., Shapiro, S.D., Dolganov, G., Glick, A., Sheppard, D. Nature (2003) [Pubmed]
  2. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. Jenkins, R.G., Su, X., Su, G., Scotton, C.J., Camerer, E., Laurent, G.J., Davis, G.E., Chambers, R.C., Matthay, M.A., Sheppard, D. J. Clin. Invest. (2006) [Pubmed]
  3. Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice. Huang, X., Wu, J., Zhu, W., Pytela, R., Sheppard, D. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  4. Alphavbeta6-Fyn signaling promotes oral cancer progression. Li, X., Yang, Y., Hu, Y., Dang, D., Regezi, J., Schmidt, B.L., Atakilit, A., Chen, B., Ellis, D., Ramos, D.M. J. Biol. Chem. (2003) [Pubmed]
  5. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. Bates, R.C., Bellovin, D.I., Brown, C., Maynard, E., Wu, B., Kawakatsu, H., Sheppard, D., Oettgen, P., Mercurio, A.M. J. Clin. Invest. (2005) [Pubmed]
  6. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Kaminski, N., Allard, J.D., Pittet, J.F., Zuo, F., Griffiths, M.J., Morris, D., Huang, X., Sheppard, D., Heller, R.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. A distinctive alveolar macrophage activation state induced by cigarette smoking. Woodruff, P.G., Koth, L.L., Yang, Y.H., Rodriguez, M.W., Favoreto, S., Dolganov, G.M., Paquet, A.C., Erle, D.J. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  8. Induction of alpha-catenin, integrin alpha3, integrin beta6, and PDGF-B by 2,8-dihydroxyadenine crystals in cultured kidney epithelial cells. Wang, L., Raikwar, N., Yang, M., Deng, L., McAteer, J.A., Stambrook, P.J., Sahota, A., Tischfield, J.A. Exp. Nephrol. (2002) [Pubmed]
  9. Characterization of integrin beta6 and thrombospondin-1 double-null mice. Ludlow, A., Yee, K.O., Lipman, R., Bronson, R., Weinreb, P., Huang, X., Sheppard, D., Lawler, J. J. Cell. Mol. Med. (2005) [Pubmed]
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