The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Cdx1  -  caudal type homeo box 1

Rattus norvegicus

This record was replaced with 364883.
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Cdx1

  • METHODS: Cdx1 expression was induced in IEC-6 intestinal epithelial cells by stable transfection, and subsequent changes in cell growth, resistance to apoptosis, migration, and differentiation were monitored [1].
  • Cdx1 promotes differentiation in a rat intestinal epithelial cell line [1].
  • RESULTS: Compared with control, IEC-6/Cdx1 cells proliferated more rapidly, were more resistant to apoptosis, and migrated 3-4 times faster, as shown by an in vitro wound assay [1].
  • CONCLUSIONS: Cdx1 expression in IEC-6 cells induces phenotypic changes characteristic of differentiating enterocytes, suggesting an important role for Cdx1 in the transition from stem cells to proliferating/transit cells [1].
  • Cdx1 might carry out that function in the intestinal epithelium because its expression is specific to that tissue and increases during development [1].
 

Biological context of Cdx1

  • On the other hand, inhibition of the PAP I expression in the IEC-6 Cdxl-expressing cells using an antisense strategy confirmed the requirement of this protein for the effect of Cdx1 on cell growth [2].
  • Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation [2].
  • After stable transfection with a Cdx1 expression vector, they produce high levels of the PAP I transcript and protein indicating a functional link between the two genes [2].
  • These effects were accompanied by the increased formation of spermidine and spermine due to the enhancement of S-adenosylmethionine decarboxylase activity and by the upregulation of Cdx-1, a homeobox gene with oncogenic potentials [3].
 

Anatomical context of Cdx1

 

Associations of Cdx1 with chemical compounds

  • Cdx1 and Cdx2, known to be transcriptional factors related to intestinal proliferation and differentiation, were more highly expressed in STZ, OLETF and GK rats than in the respective controls [4].

References

  1. Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Soubeyran, P., André, F., Lissitzky, J.C., Mallo, G.V., Moucadel, V., Roccabianca, M., Rechreche, H., Marvaldi, J., Dikic, I., Dagorn, J.C., Iovanna, J.L. Gastroenterology (1999) [Pubmed]
  2. Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I. Moucadel, V., Soubeyran, P., Vasseur, S., Dusetti, N.J., Dagorn, J.C., Iovanna, J.L. Eur. J. Cell Biol. (2001) [Pubmed]
  3. Promotion of intestinal carcinogenesis by dietary methionine. Duranton, B., Freund, J.N., Galluser, M., Schleiffer, R., Gossé, F., Bergmann, C., Hasselmann, M., Raul, F. Carcinogenesis (1999) [Pubmed]
  4. Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats. Adachi, T., Mori, C., Sakurai, K., Shihara, N., Tsuda, K., Yasuda, K. Endocr. J. (2003) [Pubmed]
 
WikiGenes - Universities